A5077610573- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Lysosomal Storage Disorders Research
- Pancreatitis Pathology and Treatment
- Calcium signaling and nucleotide metabolism
- Gallbladder and Bile Duct Disorders
- Cardiac tumors and thrombi
- Neonatal Health and Biochemistry
- Diet, Metabolism, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic function and diabetes
- Genetic and Kidney Cyst Diseases
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Galectins and Cancer Biology
- Pancreatic and Hepatic Oncology Research
- Parasitic Diseases Research and Treatment
- Abdominal Surgery and Complications
- Celiac Disease Research and Management
Universidade Estadual de Campinas (UNICAMP)
2017-2024
Hospital de Clínicas da Unicamp
2021-2022
Centro Universitário da Cidade
2022
Weatherford College
2022
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Universidade de São Paulo
2010-2014
Background and aim. The lack of information about hepatocellular carcinoma (HCC) in Brazil weakens health policy preventing deaths from the illness. aim this study was to establish cumulative incidence risk factors for development patients under a surveillance program. Material methods. 884 with compensated cirrhosis were prospectively followed up at least five years, August 1998 until 2008, one annual ultrasonography liver examination serum alpha fetoprotein (AFP) measurement. Results....
COVID-19 is commonly associated with high serum levels of pro-inflammatory cytokines, and the post-infection status can disturb self-tolerance trigger autoimmune responses. We are reporting a 45-year-old male who was admitted fatigue, jaundice, elevated liver enzymes (with cholestatic pattern), acute kidney injury two weeks after recovering from mild SARS-CoV-2 infection. Serologies for viral hepatitis anti-mitochondrial antibody were negative, while anti-nuclear anti-smooth muscle...
The EncephalApp Stroop Test was developed to more easily diagnose minimal hepatic encephalopathy (MHE). A cut-off of >274.9sec (ONtime+OFFtime) reached a 78% sensitivity and 90% specificity in the validation study, but it has been poorly studied Brazil. We aim analyze usefulness this diagnostic method describe value screen MHE Brazil.In cross-sectional single-center three positive psychometric tests defined diagnosis as gold standard. evaluated gender, age, education, familiarity with...
ABSTRACT Background and Aim Primary sclerosing cholangitis (PSC) has been shown to recur after liver transplantation (LT). Some studies have identified certain clinical laboratory variables associated with an increased risk for recurrent PSC (rPSC) in Caucasians. Furthermore, de novo cholangiocarcinoma (CCA) reported anecdotally patients rPSC. This study aims assess the prevalence of rPSC, identify its factors, investigate occurrence CCA a highly admixed population from Brazil. Methods All...
Chronic hepatitis B is a major cause of cirrhosis, and the natural history disease has several clinical stages that should be thoroughly understood for implementation proper treatment. Nonetheless, curing with antiviral treatment remains challenge. To describe course, response to treatment, poor prognostic factors in 247 virus chronic infection patients treated tertiary hospital Brazil. This was retrospective observational study, by analyzing medical records HBV infected between January 2000...
Bacterial infection is present in up to 30% of hospitalized cirrhotic patients. It can lead, even after its resolution, organ dysfunction and acute-on-chronic liver failure (ACLF). the precipitating factor ACLF one third cases main cause mortality patients with cirrhosis.The aim this study was evaluate prevalence identify early risk factors for severe death cirrhosis bacterial infection.This a prospective observational study. Hospitalized were included. Clinical laboratory data their...
Vanishing bile duct syndrome is a rare acquired condition, characterized by progressive loss of intrahepatic ducts leading to ductopenia and cholestasis. It can be associated with infections, ischemia, drug adverse reactions, neoplasms, autoimmune disease, allograft rejection. Prognosis variable depends on the etiology injury. We report case 25-year-old female cholestatic hepatitis concomitant intakes hepatotoxic substances, such as garcinia, field horsetail, ketoprofen. On suspicion...
Fibroblast growth factor 21 (FGF21) signaling and genetic factors are involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. However, these have rarely been studied type 2 diabetes mellitus (T2D) patients from admixed populations such as those of Brazil. Therefore, we aimed to evaluate rs738409 patanin-like phospholipase domain-containing protein (PNPLA3) rs499765 FGF21 polymorphisms T2D, their association with NAFLD, fibrosis, serum biomarkers (FGF21 cytokeratin 18 levels). A...
Background/Aims Inflammatory bowel disease (IBD) are chronic entities characterized by local and systemic inflammation may be associated with thrombosis. The aim of this study was to identify the prevalence thromboembolic events (TEE) in hospitalized IBD patients risk factors for their occurrence. Methods This retrospective, single-center included treated at a Brazilian referral unit between 2004 2014. Patients more than 48 hours due active who did not receive prophylaxis TEE during...
Genetic anaemias lead us to reflect on the classic 'trolley dilemma', when there are two choices but neither one is satisfactory. Either we do not treat anaemia and patient suffers from chronic tiredness fatigue, or it through blood transfusions, leading iron overload, which a quite harmful consequence.We present case of 34-year-old woman with Diamond-Blackfan (DBA). Bone marrow stem cell transplantation had been accessible during her childhood, so she submitted monthly transfusions...
Approximately 170 million people are chronic carriers of hepatitis C virus (HCV). Patients with currently treated pegylated interferon and ribavirin (PEG-IFN/RBV). A genome-wide association PEG-IFN/RBV treatment response a single nucleotide polymorphism (rs12979860) has been identified near the interleukin 28B gene that encodes interferon-λ-3. In this paper, we describe an innovative, fast, low-cost multiplex polymerase chain reaction confronting two-pair primers detects rs12979860...
Hepatitis B virus (HBV) is intrinsically oncogenic and related to hepatocellular carcinoma (HCC). Predictive scores of HCC have been developed but poorly studied in admixed populations. Therefore, we aimed evaluate the performance PAGE-B mPAGE-B for prediction HBV Brazilian patients factors occurrence. This a retrospective study that evaluated followed at tertiary university center. A total 224 were included, with median follow-up period 9 years. The mean age diagnosis was 38.71 ± 14.19...
Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) PBC overlap syndrome (AIH/PBC) have been associated with a higher risk of hepatocellular carcinoma (HCC) extra-hepatic malignancy (EHM). This study aims to assess potential factors cancer development in AIH/PBC.The Brazilian Cholestasis Study Group database was reviewed compare clinical laboratory features patients HCC EHM those without cancer.Among the 752 enrolled, 64 them AIH/PBC, 87 cancers were identified 72 patients,...
Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C compared to mono-infected patients. This study aimed compare ultrasound features selected clinical biochemical variables between virus/hepatitis co-infection (n=16) versus mono-infection (n=16).Each patient underwent abdominal ultrasound, a specific evaluation was performed order detect findings consistent chronic liver disease. Characterization spleen size, structural...
Amyloidosis of the gastrointestinal tract is usually a systemic disease. Localized amyloidosis without evidence extraintestinal involvement or an associated plasma cell dyscrasia uncommon and does not cause death. We report case patient with localized who presented protein-losing enteropathy fatal upper bleed.
Testotoxicosis is a rare cause of peripheral precocious puberty in boys caused by constitutively activating mutations the LHCG receptor. Affected males usually have normal gonadotropin profiles and fertility their adult life. Here, we described long-term follow-up 24-year-old young man with severe testotoxicosis due to de novo mutation third transmembrane helix LHCGR (p.Leu457Arg). This patient was treated different medications, including medroxyprogesterone acetate, ketoconazole,...
Lysosomal acid lipase deficiency is a poorly diagnosed genetic disorder, leading to accumulation of cholesterol esters and triglycerides in the liver, with progression chronic liver disease, dyslipidemia, cardiovascular complications. Lack awareness on diagnosis this condition may hamper specific treatment, which consists enzymatic replacement. It prevent disease its We describe case 53-year-old Brazilian man who was referred our center due cirrhosis unknown etiology. He asymptomatic had...
Direct-acting antivirals are new drugs for chronic hepatitis C treatment. They usually safe and well tolerated, but can sometimes cause serious adverse effects there is no consensus on how to treat or prevent them. We described a case of hand-foot syndrome due virus interferon-free therapy.We report the 49-year-old man with compensated liver cirrhosis genotype 1, treatment-naïve, who started viral treatment sofosbuvir, simeprevir ribavirin 12 weeks.At sixth week he had anemia, requiring...
Glucagonoma is a rare and slow-growing pancreatic tumor that usually manifests as glucagonoma syndrome. It mainly characterized by typical Dermatosis named necrolytic migratory erythema (NME), Diabetes glucagon oversecretion. Deep vein thrombosis Depression complete this set. We report the case of an advanced with liver spread, where all these 4D symptoms occurred but chronic secretory Diarrhea was most relevant feature. A 65-year-old man referred to our center investigate multiple hepatic...
Hepatitis C virus (HCV) treatment has undergone major changes in recent years. Previous interferon-based therapies have been replaced by oral direct-acting antivirals (DAA) regimens, with high sustained virologic response (SVR) rates, and a lower incidence of adverse events (AEs).To evaluate the efficacy safety DAAs for HCV subjects from two tertiary university centers Brazil.This is multicenter retrospective cohort study 532 patients chronic hepatitis (CHC), undergoing interferon-free...
Rationale: Lysosomal acid lipase deficiency (LAL-D) is a poorly diagnosed genetic disorder characterized by the accumulation of cholesteryl esters and triglycerides in many tissues, leading to dyslipidemia cardiovascular complications. In liver, deposits are found within hepatocytes Kupffer cells, generating microvesicular steatosis, progressive fibrosis, cirrhosis. Sebelipase alfa target therapy which can improve laboratory changes reduce progression liver damage, but this not yet widely...