A5052924650- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Prostate Cancer Treatment and Research
- Cervical Cancer and HPV Research
- Liver Diseases and Immunity
- Endometrial and Cervical Cancer Treatments
- Genetic and Kidney Cyst Diseases
- Colorectal and Anal Carcinomas
- Urologic and reproductive health conditions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Sarcoma Diagnosis and Treatment
- Hepatitis C virus research
- Lipoproteins and Cardiovascular Health
- Bee Products Chemical Analysis
- Colorectal Cancer Screening and Detection
- Cancer and Skin Lesions
Universidade Estadual de Campinas (UNICAMP)
2014-2024
Hospital Alemão Oswaldo Cruz
2023-2024
Amazon (United States)
2023
Brazilian Institute of Geography and Statistics
2023
Universidade Paulista
2023
Fundação de Amparo à Pesquisa do Estado do Amazonas
2023
Centro Universitário da Cidade
2022
Hospital de Clínicas da Unicamp
2019-2021
Rutgers, The State University of New Jersey
2018
Fundação Carlos Chagas
2013
Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic with several degrees of histological features which may progress to cirrhosis. Obesity an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery been associated regression in severely obese patients. However, few longitudinal studies support this finding. Therefore, firstly, retrospective study was performed including clinical data 895 patients who underwent surgery. In addition,...
High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein stage IIIB carcinoma. Methods: sixty-three patients squamous cell carcinoma were included. The evaluation by immunohistochemistry was based on positive ratio score staining intensity score. Taking disease recurrence death as endpoints, receiver operating characteristic curves...
COVID-19 is commonly associated with high serum levels of pro-inflammatory cytokines, and the post-infection status can disturb self-tolerance trigger autoimmune responses. We are reporting a 45-year-old male who was admitted fatigue, jaundice, elevated liver enzymes (with cholestatic pattern), acute kidney injury two weeks after recovering from mild SARS-CoV-2 infection. Serologies for viral hepatitis anti-mitochondrial antibody were negative, while anti-nuclear anti-smooth muscle...
Inflammatory pseudotumor (IPT) is a rare lesion consisted of inflammatory and myofibroblastic cells. These lesions may be found in different organs. There are less than 300 described cases.Case 1. 64-year-old cirrhotic male with palpable epigastric mass. CT showed liver segments 2 3 left hepatic artery aneurism. Percutaneous embolization wide spectrum antibiotics were tried, however the grew. Left lateral hepatectomy was performed, HIPT diagnosed. The patient died due to multiple organ...
Vanishing bile duct syndrome is a rare acquired condition, characterized by progressive loss of intrahepatic ducts leading to ductopenia and cholestasis. It can be associated with infections, ischemia, drug adverse reactions, neoplasms, autoimmune disease, allograft rejection. Prognosis variable depends on the etiology injury. We report case 25-year-old female cholestatic hepatitis concomitant intakes hepatotoxic substances, such as garcinia, field horsetail, ketoprofen. On suspicion...
To investigate whether quantitative computed tomography (CT) measurements can predict microvascular invasion (MVI) in hepatocellular carcinoma (HCC).This was a retrospective analysis of 200 cases surgically proven HCCs 125 consecutive patients evaluated between March 2010 and November 2017. We quantitatively measured regions interest lesions adjacent areas the liver on unenhanced CT scans, as well arterial, portal venous, equilibrium phases contrast-enhanced scans. Enhancement profiles were...
<h3>Objective</h3> The purpose of this study was to compare the immunohistochemical expression BRCA1, Ki67, and β-catenin in women with low-grade (LGSOC) high-grade serous ovarian carcinomas (HGSOC) their relationship clinicopathological features, response platinum-based chemotherapy, survival. <h3>Methods</h3> For study, 21 LGSOC 85 HGSOC stage I IV cases, diagnosed treated from 1996 2013 followed-up until December 2016, were included. assessed using tissue microarray-based...
Genetic anaemias lead us to reflect on the classic 'trolley dilemma', when there are two choices but neither one is satisfactory. Either we do not treat anaemia and patient suffers from chronic tiredness fatigue, or it through blood transfusions, leading iron overload, which a quite harmful consequence.We present case of 34-year-old woman with Diamond-Blackfan (DBA). Bone marrow stem cell transplantation had been accessible during her childhood, so she submitted monthly transfusions...
To evaluate p16INK4a immunoexpression in CIN1 lesions looking for differences between cases that progress to CIN2/3 maintain diagnosis, or spontaneously regress. Seventy-four biopsies were studied. In the follow-up, a second biopsy was performed and 28.7% showed no lesion (regression), 37.9% maintained CIN1, 33.4% progressed CIN2/3. Immunostaining first it considered positive when there strong diffuse staining of basal parabasal layers. Pearson's chi-square used compare groups (p ≤ 0.05)....
The aim of this study was to evaluate p16, cytokeratin 7 (CK7), and Ki-67 immunoexpressions in low-grade squamous intraepithelial lesion (LSIL), looking for differences among cases that progress high-grade lesion, maintain LSIL, or regress.Sixty-six LSIL biopsies were studied. In the follow-up, a second biopsy showed 28.7% regression, 37.9% 33.4% progressed lesion. Immunostaining these markers performed first biopsy. A qualitative evaluation method used, as well histomorphometry, using...
To find any influence on prognostic factors of index tumor according to predominant location.Prostate surgical specimens from 499 patients submitted radical retropubic prostatectomy were step-sectioned. Each transverse section was subdivided into 2 anterolateral and posterolateral quadrants. Tumor extent evaluated by a semi-quantitative point-count method. The (dominant nodule) recorded as the maximal number positive points most extensive area quadrants location considered anterior...
Gastrointestinal amyloidosis can be primary, more associated with monoclonal plasma cell dyscrasia, or secondary, usually secondary to a tissue-destructive, chronic inflammatory process (such as bowel disease, for example) and long-term dialysis. The rare presentation of severe acute liver failure in systemic make this diagnosis/ management difficult. Hepatomegaly signs diffuse infiltrative disease periportal involvement thoracic other abdominal radiological findings the appropriate clinical...
Objectives: To evaluate the expression of miR-126-3p and its potential as a biomarker for cholangiocarcinoma (CCA) to better understand prognosis, comorbidities, lifestyle habits associated with disease. Methods: Fifty-nine individuals were distributed into either study group (38 CCA patients) or control (21 without liver diseases). Total RNA was extracted, cDNA synthesis performed, assessed using real-time PCR. For statistical analysis, alpha error set at 5%. Results: MiR-126-3p found be...
Glucagonoma is a rare and slow-growing pancreatic tumor that usually manifests as glucagonoma syndrome. It mainly characterized by typical Dermatosis named necrolytic migratory erythema (NME), Diabetes glucagon oversecretion. Deep vein thrombosis Depression complete this set. We report the case of an advanced with liver spread, where all these 4D symptoms occurred but chronic secretory Diarrhea was most relevant feature. A 65-year-old man referred to our center investigate multiple hepatic...
Neurological manifestations have been identified in the context of autoimmune hepatitis (AIH). Previous case reports highlighted association between AIH and sensory neuronopathy (SN). Despite that, little is known about frequency AIH-related SN its clinical/neurophysiological profile. Moreover, it not clear whether an AIH-specific manifestation or related to chronic liver damage.Seventy consecutive patients were enrolled their characteristics compared with 52 active B. All subjects underwent...
Challenging lesions, difficult to diagnose through non-invasive methods, constitute an important emotional burden for each patient regarding a still uncertain diagnosis (malignant x benign). In addition, from therapeutic and prognostic point of view, delay in definitive can lead worse outcomes. One the main innovative trends currently is use molecular functional methods diagnosis. Numerous liver-specific contrast agents have been developed studied recent years improve performance liver...
Researchers from different fields have studied the causes of obesity and associated comorbidities, proposing ways to prevent treat this condition by using a common animal model create profound energy imbalance in young adult rodents. However, confirm harmful effects consuming high-fat hypercaloric diet, it is include normolipidic normocaloric control groups experimental protocols. This study compared effect three diets described literature – namely, high-sucrose high-fructose diet induce...