A5081088400- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Veterinary medicine and infectious diseases
- earthquake and tectonic studies
- Clostridium difficile and Clostridium perfringens research
- Economic Theory and Policy
- Galectins and Cancer Biology
- Seismic Waves and Analysis
- Antimicrobial Resistance in Staphylococcus
- Seismology and Earthquake Studies
- Earthquake Detection and Analysis
- Geological and Tectonic Studies in Latin America
- Seismic Imaging and Inversion Techniques
- Cancer-related gene regulation
- Socioeconomic Development in Asia
- Geomagnetism and Paleomagnetism Studies
- Genetic factors in colorectal cancer
- Viral gastroenteritis research and epidemiology
- Methane Hydrates and Related Phenomena
- Geological and Geochemical Analysis
- Computational Fluid Dynamics and Aerodynamics
- Quality and Safety in Healthcare
- Youth Education and Societal Dynamics
- Gastric Cancer Management and Outcomes
- Social Sciences and Policies
Chinese Academy of Sciences
2022-2025
Immunité et Cancer
2025
New Mexico State University
2024
Institut Pasteur of Shanghai
2022-2023
Mexican Social Security Institute
2020-2022
Colombian Geological Survey
1997-2020
Instituto Politécnico Nacional
2014-2017
Fundación Tecnológica Antonio de Arévalo
2013-2015
University of Cartagena
1997
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
H. pylori (HP) genetics may determine its clinical outcomes. Despite high prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies the region. We aimed to understand structure populations LA mestizo individuals, where gastric cancer incidence remains high. The genome 110 strains from Mexico, Nicaragua and Colombia were analyzed with 59 worldwide available genomes. To study bacterial relationship on whole level we propose a virtual hybridization technique...
Abstract Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to speciation Homo sapiens. A history pathogen evolution in allopatry has led development genetically distinct H. subpopulations, associated with different populations, and more recent admixture among subpopulations can provide information about migrations. However, little known degree which some genes are conserved face admixture, potentially indicating host adaptation, or how virulence...
Helicobacter pylori strains carry a range of mutations in genes that confer antimicrobial resistance and restrict the available options to treat infection. Latin America is region conserve large number indigenous communities relatively isolated practice traditional medicine without consumption drugs. We hypothesized rates antibiotic are lower these communities. Recent progress whole-genome sequencing has allowed study drug susceptibility by searching for known associated with resistance. The...
Abstract Helicobacter pylori disturbs the stomach lining during long-term colonization of its human host, with sequelae including ulcers and gastric cancer 1,2 . Numerous H. virulence factors have been identified, showing extensive geographic variation 1 Here we identify a ‘Hardy’ ecospecies that shares ancestry ‘Ubiquitous’ from same region in most genome but has nearly fixed single-nucleotide polymorphism differences 100 genes, many which encode outer membrane proteins host interaction...
ABSTRACT The increasing antibiotic resistance of Helicobacter pylori has had a serious impact on gastric cancer prevention. Our study aimed to profile the genomic characteristics and explore variants associated with in H. strains from high-risk area China. We isolated 153 community-based cohort assessed their susceptibility six antibiotics by MIC Test Strip whole-genome sequencing. Phylogenetic analysis identified as an independent cluster within East Asian population (hpEastAsia). HefA ,...
Chronically homeless adults (CHA) often face limited healthcare access, poor nutrition, frequent substance use, and close contact with stray animals. These factors can significantly alter their oral microenvironment. This study aimed to characterize the microbiota of this vulnerable understudied population. We analyzed saliva samples from 60 chronically men 40 asymptomatic no history homelessness, all living in Mexico City. DNA was extracted, V1-V3 regions 16S rRNA gene were sequenced....
Clostridioides difficile is a global public health problem, which primary cause of antibiotic-associated diarrhea in humans. The emergence hypervirulent and antibiotic-resistant strains associated with the increased incidence severity disease. There are limited studies on genomic characterization C. Latin America. We aimed to learn about molecular epidemiology antimicrobial resistance from adults children hospitals México. studied 94 isolates seven Mexico City 2014 2018. Whole-genome...
We conducted a global-scale study to identify H. pylori antimicrobial-resistant genes (ARG), address their global distribution, and understand effect on the antimicrobial resistance (AMR) phenotypes of clinical isolates. identified ARG using several well-known tools against extensive bacterial databases, then analyzed correlation with antibiogram data from dozens patients across countries. This revealed that combining multiple followed by manual selection annotation results, produces more...
SUMMARY Long-period (LP) seismic events at active volcanoes are thought to be generated by oscillations of fluid-filled resonators. The resonator geometry and fluid properties LP sources have been estimated comparing observed frequencies quality factors (Q) with those calculated numerical simulations a crack model. A method estimate all the parameters using an analytical formula for resonance has recently proposed, but this requires long computational times compare simulated Q values,...
Abstract Seismic scattering and attenuation at volcanoes, thought to be strongest on the Earth, can used map volcanic feeding systems. We systematically analyzed high‐frequency (5–10 Hz) seismograms of volcano‐tectonic earthquakes Galeras volcano (Colombia) active sources Kirishima, Unzen, Bandai, Iwate volcanoes (Japan) investigate their characteristics. The envelope widths estimated from these were compared with those calculated by Monte Carlo simulations for 1D layered models...
ABSTRACT Helicobacter pylori strains are the major risk factor for gastric cancer. Strains vary in their content of disease-associated genes, so genome-wide analysis cancer-isolated will help elucidate pathogenesis and genetic diversity. We present draft genome sequence H. isolated from a Mexican patient with intestinal
Abstract The colonization of our stomachs by Helicobacter pylori is believed to predate the oldest splits between extant human populations. We identify a “Hardy” ecospecies H. associated with indigenous groups, isolated from people in Siberia, Canada, USA and Chile. shares ancestry “Ubiquitous” same geographical region most genome but has nearly fixed SNP differences 100 genes, many which encode outer membrane proteins host interaction factors. For these parts genome, separate, independently...
In the Puracé volcano, a study of “tornillo” seismic event was conducted for period between 2000 and 2012. To characterize generation source nature fluids that interact in internal cracks Q factor resonator dominant frequencies were calculated using Sompi method. It found values varied 100 400 on average some periods (2010), reached up to 1200. The presented different ranges (1.5-13 Hz), with predominant 6 Hz. possible observe temporal variations both complex frequency, which could be...
En el presente trabajo se muestran los hallazgos de un análisis realizado a las Pymes metalmecánicas en Cartagena, con objetivo determinar su situación actual sobre actividades Seguridad y Salud Trabajo acuerdo directrices del Sistema Gestión la Trabajo, esta manera establecer si están aplicando normas vigentes que rigen Colombia. Se recurre técnica estudio caso través instrumento diagnóstico, aplicado 10 ciudad Cartagena. Menos 50% estas encuentran comprometidas SG-SST
La apremiante necesidad de lograr desarrollo economico en la region latinoamericana que conduce al debate sobre cual debe ser el modelo a seguir. De decision correcta depende futuro economico.?Debe Latinoamerica seguir un paternalista o; estilo Singapur, optar por meritocracia? Se propone termino medio: dar oportunidades para todos, pero condicionada obtencion parametros desempeno.Este articulo aborda cultura como elemento propiciador u obstaculo economico. expone fomentada activamente...
Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America, H. has evolved into several subpopulations. We analysed the genome of 154 Colombian strains along 1,091 from worldwide populations discern ancestry and adaption people. Population structure was inferred FineStructure ChromoPainter. Phylogenetic relationship relative effect recombination were analysing core SNPs. Also, a Fst index calculated identify gene variants strongest...
Abstract Background: Infection with Helicobacter pylori is recognized as the main risk factor for gastric cancer (GC); clinical outcome of this infection variable and partially depends on virulence infective strain. This study characterizes H. genes in patients diverse lesions, from preneoplasia to GC, a South American region high GC mortality rates. Methods: We studied profiles strains colonize antrum 318 non-atrophic gastritis (NAG), 58 preneoplastic lesions (PN), 90 Ibagué, Colombia. The...
Abstract Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America H. has evolved in several subpopulations specific for regions or even countries. this study we analyzed the genome of 163 Colombian strains along 1,113 that represent worldwide populations better discern ancestry and adaption people. Population structure was inferred FineStructure chromosome painting identifying proportion ancestries isolates. Phylogenetic relationship...
Este trabajo tiene por objeto estimar qué tipo de relación ha existido entre el PIB y las exportaciones en Colombia periodo 2000-2010, igual modo se medirá efecto positivo, negativo o neutro existente e inflación período. A través una prueba verificación empírica busca dar indicios sobre la validez teorías que explican los efectos crecimiento del PIB. Se hace uso método regresión lineal múltiple, juicio validez, teoría lleva a cabo siguiendo un enfoque positivista – contraste empírico...
Abstract BACKGROUND: Helicobacter pylori, a gram-negative bacterium associated with spectrum of benign and malignant gastric conditions, is one the most genetically variable pathogens. Its genome encodes large number DNA methyltransferases targeting specific motif sequences ∼4-15 bp. base modifications epigenetically regulate gene expression genome-wide methylation profiles (methylomes) have been hypothesized to be virulence. A limited H. pylori methylomes published date, precluding...