A5067874952- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Salmonella and Campylobacter epidemiology
- Clostridium difficile and Clostridium perfringens research
- Veterinary medicine and infectious diseases
- Diet and metabolism studies
- Antibiotic Resistance in Bacteria
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Parkinson's Disease Mechanisms and Treatments
- Synthesis and biological activity
- Antibiotic Use and Resistance
- Dysphagia Assessment and Management
- Synthesis and Characterization of Heterocyclic Compounds
- Nutritional Studies and Diet
- Diphtheria, Corynebacterium, and Tetanus
- Galectins and Cancer Biology
- Nanomaterials for catalytic reactions
- Escherichia coli research studies
- Breastfeeding Practices and Influences
- Wastewater Treatment and Reuse
- Synthesis of heterocyclic compounds
- Phytochemistry and Bioactive Compounds
Wellcome Sanger Institute
2025
University of Cambridge
2021-2024
Manipal Academy of Higher Education
2014-2024
Kasturba Medical College, Manipal
2015-2024
International Centre for Diarrhoeal Disease Research
2021
Enter (Switzerland)
2021
University of Delhi
2021
Czech Academy of Sciences, Institute of Microbiology
2019
Mangalore University
2015
In the present work, gold (Au), silver (Ag), and copper (Cu) based mono- bimetallic NPs are prepared using a cost-effective facile wet chemical route. The pH for synthesis is optimized in accordance with optical spectra supported by finite difference time domain simulation studies. FESEM TEM micrographs used to analyze morphology of nanoparticles. images nanoparticles (BMPs) verified their nature. XRD studies confirmed formation fcc-structured NPs. Photoluminescence as-synthesized good...
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
Due to increased prevalence of H. pylori antimicrobial resistance worldwide and more importantly the patterns vary between different geographical regions, it is important survey local antibiotic profile provide physicians with informed drug choices better treat infection. To our knowledge, this first study examine in Karnataka state South India.A total 113 strains were isolated from gastric biopsies tested: 81.4% resistant metronidazole, 54.9% levofloxacin, 20.4% clarithromycin, 5.3%...
In recent times, discovery efforts for novel antibiotics have mostly targeted carbapenemase-producing Gram-negative organisms. Two different combination approaches are pertinent: β-lactam-β-lactamase inhibitor (BL/BLI) or β-lactam-β-lactam enhancer (BL/BLE). Cefepime combined with a BLI, taniborbactam, BLE, zidebactam, has been shown to be promising. this study, we determined the
Genomic pathogen surveillance is a powerful tool for public health and research, but costly unachievable in low-resource settings. Most sub-genomic typing methods sacrifice resolution whilst remaining costly. We developed "Phylo-Plex", novel approach that identifies information-rich genomic regions to maximise phylogenetic information minimising the number of regions. Applied Treponema pallidum, we designed high-resolution multiplex PCR sequencing scheme lineage tracking. Using MinION...
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children low- and middle-income countries (LMICs). However, large-scale pathogen burden studies have identified ETEC the guts both symptomatic patients controls. The factors that influence this balance are poorly understood, but it postulated gut microbiome may play a role either resistance or progression to disease. In study, we profiled microbiomes adults from Bangladesh who were asymptomatically symptomatically...
Objectives: Recent advancement in understanding neurological disorders has revealed the involvement of dysbiosis gut microbiota pathophysiology Parkinson’s disease (PD). We sequenced microbial DNA using fecal samples collected from PD cases and healthy controls (HCs) to evaluate role microbiota. Methods: Full-length bacterial 16S rRNA gene sequencing was performed amplified polymerase chain reaction (PCR) products on GridION Nanopore sequencer. Sequenced data were analyzed web-based tools...
Introduction.Vibrio furnissii is a motile, Gram-negative, oxidase-positive, halophilic bacteria first defined in 1977. It ubiquitously present marine environments and one of the 11 non-cholera Vibrio species pathogenic humans, which can lead to human gastroenteritis extra-intestinal manifestations. Case presentation. A 73-year-old female patient was admitted hospital with acute after consumption seafood, later by microbiological investigations confirmed as furnissii, member family...
Cost-effective diagnostic platforms for rapid pathogen detection are always incumbent in both developing and developed worlds. However, exorbitant expenses the inability to detect pathogens early a matter of concern sustainability affordability healthcare devices, which crucial deciding how provide solutions masses, especially countries. Herein, we present real-time Salmonella Typhimurium using an inexpensive lab-built surface plasmon resonance (SPR) imaging set up. Pathogen is accomplished...
Globally, H. pylori virulence factors cagA and vacA genotypes its variation is leading to the austere form of gastroduodenal disease. Our objectives were detect in dyspeptic patients from biopsy samples with validation various existing diagnostic tools screen cagA, profile specimens how it impacts progression disease southern India.374 who attended endoscopy unit at Kasturba Hospital, Manipal their consent obtained biopsies. detected by HPE, Culture, RUT PCR gene patterned PCR.The positive...
Introduction: Gastroenteritis is recognized as a serious public health problem in India. It syndrome that can be caused by different bacterial, viral and parasitic pathogens. Indiscriminate use of antibacterial agents has resulted the development multidrug resistant organisms. A retrospective study was done to analyze etiological spectrum diarrhoea determine antimicrobial resistance pattern bacterial Methodology: Fecal specimens from patients with acute or chronic were received prior...
Human infection with non-typhoidal Salmonella (NTS) serovars is often a neglected and undiagnosed in the developing world. Invasive NTS now being established as having new emerging pathogenic role. There not sufficient data on prevalence of their antibiotic susceptibility pattern from India. Faecal specimens collected patients acute gastroenteritis were processed to isolate according standard protocol for period January 2011–December 2014. isolates serotyped tested susceptibility. Of total...
BackgroundInfancy is a very crucial phase of comprehensive development. Optimum nutrition has the potential to boost immunity and decrease disease susceptibility. Our hypothesis that exclusive breastfeeding homebased complementary feeding improves gastrointestinal health reduces antibiotic exposure in infants, comparison partial breast mixed feeding. Very few studies have explored this topic rural Indian setting.MethodsA prospective cohort study was conducted with sample size 200 mothers...
Background: Helicobacter pylori affects almost half of the world's population and therefore is one most frequent persistent bacterial infections worldwide. H. associated with chronic gastritis, ulcer disease (gastric duodenal), mucosa-associated lymphoid tissue lymphoma, gastric cancer. Several diagnostic methods exist to detect infection option method or another depends on various genes, such as availability, advantages disadvantages each method, monetary value, age patients. Materials...
Objective: Biliary tract infections include cholangitis and cholecystitis. They are associated with high morbidity mortality in elderly patients co-morbid disease. The present study was undertaken to determine the microbial aetiology causing biliary also their antimicrobial resistance profile.Materials & methods: A retrospective conducted from January 2011 December 2016 at Enteric Diseases Division, Kasturba Medical College Hospital, Manipal. Patients admitted tertiary referral health...
The drivers underpinning the emergence of SARS-CoV-2 and climate change attest to fact that we are now living in Anthropocene Epoch, with human activities significantly impacting altering global ecosystem. Here, explore historical context zoonoses, effect anthropogenic interrelated on of, response emerging infectious diseases. We call attention an urgent need for inculcating a One Health research agenda acknowledges primary interconnection between animals, humans, pathogens, their collective...
AcceptedJune 3, 2015.J-STAGE AdvancePublication July10, 2015.DOI: 10.7883/yoken.JJID.2014.474*Corresponding author: Mailing address: Enteric DiseasesDivision–Incharge, Central Research Lab, Kasturba Medi-cal College, Manipal University, Manipal-576104, Kar-nataka, India. Tel: 91 820 2922651, Fax: 2571927,E-mail: mamatha_98＠yahoo.comJpn. J. Infect. Dis., 68, 530–531, 2015
Abstract Background Young Indian immigrants and Indo-Canadians face a significantly higher risk of inflammatory bowel disease (IBD) in westernized countries. While the etiology IBD remains unclear, gut microbiome that is no longer symbiotic with its host key player. However, Indians are underrepresented research, therefore we cannot accurately assess role their IBD. To understand why at greater for Canada, must first characterize microbiome. Aims This study explores how immigration to Canada...
Background Indian immigration to westernized countries has surged in recent years, with this demographic facing a higher risk of Inflammatory Bowel Disease (IBD) after migration. Studying the gut microbiome is crucial understanding factors contributing IBD, yet Indians remain underrepresented research, Objective This study investigates residing India, immigrants Canada, and Canadians ancestry understand impact westernization on their gut. Given IBD among Indo-Canadians, these results provide...
Antibiotic resistance poses a significant global health threat, necessitating innovative approaches to combat it effectively. This survey paper presents comprehensive overview of the challenges associated with antibiotic and critical role susceptibility testing (AST) in guiding treatment decisions. We propose leveraging advancements image processing machine learning develop an automated algorithm for measuring Zone Inhibition AST, addressing limitations manual methods. Additionally, we...
<title>Abstract</title> <italic><bold>Background: </bold></italic>Indian immigration to westernized countries has surged in recent years, with this demographic facing a higher risk of Inflammatory Bowel Disease (IBD) after migration. Studying the gut microbiome is crucial understanding factors contributing IBD, yet Indians remain underrepresented research, <italic><bold>Objective:</bold></italic><italic> </italic>This study investigates residing India, Indian immigrants Canada, and Canadians...