A5044954815- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Antimicrobial Resistance in Staphylococcus
- Salmonella and Campylobacter epidemiology
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Essential Oils and Antimicrobial Activity
- Bacterial Identification and Susceptibility Testing
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Escherichia coli research studies
- Pomegranate: compositions and health benefits
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Streptococcal Infections and Treatments
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plant Pathogenic Bacteria Studies
- Chromatin Remodeling and Cancer
- Agricultural Practices and Plant Genetics
- Protein Degradation and Inhibitors
- Hibiscus Plant Research Studies
- Meningioma and schwannoma management
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
All India Institute of Medical Sciences
2020-2024
Manipal Academy of Higher Education
2011-2023
Melaka Manipal Medical College
2014-2023
Banaras Hindu University
2011
ABSTRACT The expression of inducible nitric oxide synthase (iNOS) and the production (NO) are important host defense mechanisms against pathogens in mononuclear phagocytes. objectives this study were to examine roles mitogen-activated protein kinases (MAPKs) transcription factors (nuclear factor-κB [NF-κB] activating 1 [AP-1]) peptidoglycan (PGN)-induced iNOS NO macrophages. PGN is a cell wall component Gram-positive bacteria that stimulates inflammatory responses both ex vivo . activation...
Introduction: Gastroenteritis is recognized as a serious public health problem in India. It syndrome that can be caused by different bacterial, viral and parasitic pathogens. Indiscriminate use of antibacterial agents has resulted the development multidrug resistant organisms. A retrospective study was done to analyze etiological spectrum diarrhoea determine antimicrobial resistance pattern bacterial Methodology: Fecal specimens from patients with acute or chronic were received prior...
Biliary candidiasis is increasing in the hospitalized immunosuppressed individuals. Placement of biliary stents cancer patients with obstructive jaundice has been found to be an important factor associated infectious complications. Positive fungal cultures from bile should not ignored as mere contamination but considered when prescribing treatment for recurrent cholangitis or receiving long-term antibiotic therapy. Here,we report a case cholangiocarcinoma where Candida tropicalis was sole...
Abstract Background Diffuse midline gliomas (DMGs) are malignant tumors predominantly affecting children, often leading to poor outcomes. The 2021 World Health Organization classification identifies 3 subtypes of DMGs, all characterized by the loss H3K27 trimethylation. Here, we report 2 cases DMG with Epidermal Growth Factor Receptor (EGFR) mutations within exon 20, contributing understanding molecular complexity these pediatric brain tumors. Methods An economical immunohistochemical panel...
Background: Ulcerative colitis (UC) is an inflammatory bowel disorder affecting the colonic mucosa, characterized by intense inflammation and mucosal damage. The present study aimed to evaluate protective effect of Trigonellafoenum-graecum L. (TFG) seeds in acetic acid-induced UC rats. Materials Methods: Male rats (n=30) were distributed into 5 groups as normal control, UC, standard, two test groups. Colitis was induced acid all except control group. Normal group received distilled water,...
Abstract Background Immune evasion is an important hallmark of cancer progression and tumourigenesis. Among the types, cervical has very high global prevalence, severely affecting female reproductive health. Its preponderance also observed in Indian health sector. Results The NLRP3 inflammasome, intracellular complex regulates innate immune activity a variant gene it been significantly associated with development. We aimed to evaluate potential role our chitosan engineered nanoparticles...
Objective: Recurrent Clostridium difficile infection (CDI) and the emergence of strains with reduced susceptibility to metronidazole vancomycinwarrants alternative therapy. Hence, we tested potential efficacy natural compound berberine hydrochloride (BBRHCl) against toxigenicC. difficile.Methods: Three representative polymerase chain reaction confirmed, toxin-positive were included in study. Pulsed-field gel electrophoresis(PFGE) profile antibiogram analyzed along 10 other toxin positive...
Challenges in obtaining tissue specimens and tumor heterogeneity are major limitations for accurate diagnosis, molecular characterization, risk stratification, development of biomarker-driven therapies central nervous system (CNS) tumors. The potential assessment CNS tumors through analysis corporeal fluids (liquid biopsy) is being explored to document tumor-related genetic/epigenetic alterations protein expression identify prognostic therapeutic biomarkers. quantity circulating DNA isolated...
Abstract Study question Do NOD-like receptor pyrin-containing 3 (NLRP3) signaling affect neutrophil extracellular traps (NET)-osis in women with stage III/IV endometriosis? Summary answer Inflammasome activation whether due to pathogen (disease itself) or damage-associated molecular pattern (through NET) might be one mechanism involved establishing perturbed endometrium endometriosis. What is known already Endometriosis characterized by number of processes like vascularization,...