A5021013614- Reproductive System and Pregnancy
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Physiology in Livestock
- Spectroscopy Techniques in Biomedical and Chemical Research
- Lipid metabolism and disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Cardiovascular Issues in Pregnancy
- Folate and B Vitamins Research
- Animal Virus Infections Studies
- Gestational Diabetes Research and Management
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Renal Diseases and Glomerulopathies
Institute of Reproductive Medicine
2013-2025
Indian Institute of Technology Kharagpur
2022
University of Calcutta
2017-2022
Indian Institute of Science Education and Research Mohali
2013
Indian Institute of Chemical Biology
2012
Recurrent pregnancy loss (RPL) in polycystic ovary syndrome (PCOS), which occurs ∼50% of total pregnancies is a frequent obstetric complication. Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s RPL. This study was conducted to assess link between elevated levels homocysteine IR PCOS-associated women with RPL Kolkata, India. A retrospective one hundred twenty six PCOS (<30 years) who experienced two or more spontaneous...
In naturally polygamous organisms such as Drosophila, sperm competitive ability is one of the most important components male fitness and expected to evolve in response varying degrees male–male competition. Several studies have documented existence ample genetic variation males. However, many experimental evolution found be unresponsive selection. Even direct selection for increased has failed yield any measurable changes. Here we report (sperm defense-P1, offense-P2) a set replicate...
SUMMARY Prolonged and strenuous exercise has been proposed as a possible source of male‐factor infertility. Forced intensive swimming also identified one dysfunctional male reproduction system. The present study evaluated the protective role α‐lipoic acid N ‐acetylcysteine (NAC) on swimming‐induced germ‐cell depletion in adult rats. exhaustive 1 hr/day, 6 days/week for 8 consecutive weeks resulted significant ( P < 0.05) reduction epididymal sperm; testicular androgenic enzyme activities;...
Clinical evidence suggests an association between galactosaemia and premature ovarian insufficiency (POI); however, the mechanism still remains unresolved. Experimental galactose toxicity in rats produces array of dysfunction including development with deficient follicular reserve resistance to gonadotrophins that characterize basic tenets human POI. The present investigation explores if attenuates bioactivity or interferes their receptor competency, accelerates rate atresia. Pregnant were...
Benzo(a)pyrene [B(a)P] is the toxic environmental Polycyclic Aromatic Hydrocarbon (PAH), that exerts male reproductive dysfunctions. In this study molecular mechanism of B(a)P induced Leydig cell steroidogenic dysfunctions and its protective action with a natural Aryl hydrocarbon receptor (AhR) antagonist anti-oxidant, Resveratrol (Res) has been investigated. exposure ROS mediated imbalance via activation p38MAPK repression testosterone level as well other enzymes like CYPIIA1, 3β-HSD,...
Recurrent spontaneous miscarriage refers to the repeated loss of two or more clinically detected pregnancies occurring within 24 weeks gestation. No identifiable cause has been identified for nearly 50% these cases. This group is referred as idiopathic recurrent (IRSM) unknown origin. Due lack robust scientific evidence, guidelines on diagnosis and management IRSM are not well defined often contradictory. motivates us explore vibrational fingerprints endometrial tissue in women. Endometrial...
The tubers of Pueraria tuberosa have folkloric repute as emmenagogue. n-BuOH fraction the ethanolic extract exhibits significant antifertility activity in laboratory animals. present investigation explored active principle(s) tuber with reference to contragestive effects rats and probed possible mechanism action. Bioactivity-guided fractionation identified puerarin major constituent that exerted pregnancy-terminating effects. Oral administration at ≥300 mg/kg per day for days (D) 1-2...
As a part of our continued venture to develop safe and effective spermicide, we have identified triterpene glycoside (Acaciaside-B (Ac-B))-enriched fraction (Ac-B- en ) isolated from the seeds Acacia auriculiformis evaluated its spermicidal potential in vitro . Sperm motility was completely inhibited within 20 s at minimum concentration (MEC) 120 μg/ml. Tests for sperm viability by dual fluoroprobe staining showed effect be with an EC 50 35.20 A series investigations including tests...
The management of recurrent pregnancy loss (RPL) still remains a great challenge, and women with polycystic ovarian syndrome (PCOS) are at greater risk for spontaneous abortion. Treatment low-molecular-weight heparin (LMWH) has become an accepted treatment option RPL; however, the subgroup women, who likely to respond LMWH, not been precisely identified. present study evaluated efficacy LMWH reference PCOS associated metabolic phenotypes including hyperhomocysteinemia (HHcy), insulin...
Abstract Fenugreek (Trigonella foenum graecum), a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study aimed explore the interaction of fenugreek seed extract (FSE) HPT (hypothalamic-pituitary-thyroid) axis in context leptin secretion which have important role normal type-1 diabetic subjects. FSE (confirmed contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) alloxan-induced rats for weeks....