A5057989350- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Reproductive System and Pregnancy
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Endometriosis Research and Treatment
- Medical Imaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Endometrial and Cervical Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Metabolomics and Mass Spectrometry Studies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Electron Spin Resonance Studies
- Birth, Development, and Health
- Diagnosis and treatment of tuberculosis
- Bone Tissue Engineering Materials
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
The University of Texas MD Anderson Cancer Center
2020-2024
Indian Institute of Technology Kharagpur
2012-2022
University of California, San Francisco
2018-2021
University of California System
2019-2020
McGill University
2016
Poor endometrial perfusion during implantation window is reported to be one of the possible causes idiopathic recurrent spontaneous miscarriage (IRSM). We have tested hypothesis that certain angiogenic and vasoactive factors are associated with vascular dysfunction in IRSM and, therefore, could play a contributory role making endometrium unreceptive these women. This prospective case-controlled study carried out on 66 women age BMI matched 50 fertile serving as controls. Endometrial...
Regeneration of full-thickness wounds without scar formation is a multifaceted process, which depends on in situ dynamic interactions between the tissue-engineered skin substitutes and newly formed reparative tissue. However, majority used so far wound healing cannot mimic natural extracellular matrix (ECM) complexity thus are incapable providing suitable niche for endogenous tissue repair. Herein, we demonstrated simple approach to fabricate porous hybrid ECM sponges (HEMS) using placental...
Abstract Endometriosis is a common benign gynecological disease, characterized by growth and proliferation of endometrial glands stroma outside the uterus. With studies showing metabolic changes in various biofluids endometriosis women, we have set upon to investigate whether tissue show differences their profiles. 1 H NMR analysis was performed on eutopic women with controls. Analysis spectral data relative concentrations metabolites obtained from spectra using multivariate univariate...
Abstract 70–90% of low-grade gliomas and secondary glioblastomas are characterized by mutations in isocitrate dehydrogenase 1 (IDHmut). IDHmut produces the oncometabolite 2-hydroxyglutarate (2HG), which drives tumorigenesis these tumors. The phosphoinositide-3-kinase (PI3K)/mammalian target rapamycin (mTOR) pathway represents an attractive therapeutic for gliomas, but noninvasive indicators drug modulation lacking. goal this study was therefore to identify magnetic resonance spectroscopy...
Impaired wound healing is primarily associated with inadequate angiogenesis, repressed cell migration, deficient synthesis of extracellular matrix (ECM) component/growth factors, and altered inflammatory responses in the bed environment.
Placental extracellular matrix for osteochondral defects.
Mor-HSA-NPs and EC-HSA-NPs are effective on MDA-MB-468 breast cancer cell lines.
Nanoencapsulation has emerged as a promising approach for the effective delivery of poorly aqueous soluble compounds. The current study focuses on preparation human serum albumin (HSA)-based nanoparticles (NPs) and poly lactic-co-glycolic acid (PLGA)-based morin-Cu(II) complex. NPs were analyzed based different parameters such particle size, surface charge, morphology, encapsulation efficiency, in vitro release properties. average sizes found to be 214 ± 6 nm Mor-Cu-HSA-NPs 185 7.5...
Does investigation of metabolic perturbations in endometrial tissue women with dormant genital tuberculosis (GTB) during the window implantation (WOI) assist improving understanding receptivity? In GTB cases significant alterations metabolites occur, largely related to energy metabolism and amino acid biosynthesis cases. As an intracellular pathogen, Mycobacterium strongly influences host cells causing dysregulation. It is also accepted that impairs receptive status endometrium. Global...
Mutations in isocitrate dehydrogenase 1 (IDH1mut) are reported 70-90% of low-grade gliomas and secondary glioblastomas. IDH1mut catalyzes the reduction α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2-HG), an oncometabolite which drives tumorigenesis. Inhibition is therefore emerging therapeutic approach, inhibitors such as AG-120 AG-881 have shown promising results phase 2 clinical studies. However, detection response these therapies prior changes tumor growth can be challenging. The goal...
Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake cancer, but inhibitors of these processes have not benefited patients. A better understanding how cancer cells access lipids once they are created or taken up stored could uncover more effective strategies to perturb treat Here, we identified that expression adipose triglyceride lipase (ATGL), an enzyme controls droplet homeostasis previously suspected tumor...
Abstract Although lower grade gliomas are driven by mutations in the isocitrate dehydrogenase 1 (IDH1) gene and less aggressive than primary glioblastoma, they nonetheless generally recur. IDH1-mutant patients increasingly being treated with temozolomide, but early detection of response remains a challenge there is need for complementary imaging methods to assess therapy prior tumor shrinkage. The goal this study was determine value magnetic resonance spectroscopy (MRS)–based metabolic...
Glutathione (GSH) is often upregulated in cancer, where it serves to mitigate oxidative stress. γ-glutamyl-transferase (GGT) a key enzyme GSH homeostasis, and compared normal brain its expression elevated tumors, including primary glioblastoma. GGT therefore an attractive imaging target for detection of The goal our study was assess the value hyperpolarized (HP) γ-glutamyl-[1-13C]glycine non-invasive Nude rats bearing orthotopic U87 glioblastoma healthy controls were investigated. Imaging...
Introduction The pentose phosphate pathway (PPP) is essential for NADPH generation and redox homeostasis in cancer, including glioblastomas. However, the precise contribution to tumor proliferation of second PPP enzyme 6-phosphogluconolactonase (PGLS), which converts 6-phospho-δ-gluconolactone 6-phosphogluconate (6PG), remains unclear. Furthermore, non-invasive methods assessing PGLS activity are lacking. goal this study was examine role glioblastomas assess utility probing using...
Dysregulation in NAD+/NADH levels is associated with increased cell division and elevated of reactive oxygen species rapidly proliferating cancer cells. Conversion the ketone body acetoacetate (AcAc) to β-hydroxybutyrate (β-HB) by mitochondrial enzyme dehydrogenase (BDH) depends upon NADH availability. The β-HB-to-AcAc ratio therefore expected reflect redox. Previous studies reported potential hyperpolarized 13C-AcAc monitor redox cells, perfused organs vivo. However, ability cross blood...
Introduction . Optical trapping is a laser-based method for probing the physiological and mechanical properties of cells in noninvasive manner. As sperm motility an important criterion assessing male fertility potential, this technique used to study cell behavior rotational dynamics. Methods Patients An integrated optical system with near-infrared laser beam has been analyze dynamics live from oligozoospermic asthenozoospermic cases compared controls. Results The linear, translational motion...