Advancements in chemical, medical, cosmetic, and plastic producing industries have improved agricultural yields, health human life general. As a negative consequence, plethora of chemicals are intentionally unintentionally released to terrestrial aquatic environments with sometimes devastating effects for entire ecosystems. One mitigation strategy counteract this pollution is bioremediation. Bioremediation an umbrella term biologically mediated processes during which undesired compound...

The bark extract of Mimusops elengi is rich in different types plant secondary metabolites such as flavonoids, tannins, triterpenoids and saponins. present study shows the usefulness for green synthesis gold nanoparticles water at room temperature under very mild conditions. was complete within a few minutes without any extra stabilizing or capping agents polyphenols acted both reducing well agents. synthesized colloidal were characterized by HRTEM, surface plasmon resonance spectroscopy...

Protein misfolding and aggregation have attracted immense research interests due to their connection with an array of degenerative diseases including neurodegenerative disorders non-neuropathic diseases. Inhibition or diminution the formation protein aggregates is considered as a potential therapeutic strategy cure these debilitating maladies. A large number compounds flavonoids, surfactants, osmolytes, vitamins, nanoparticles, etc. been explored for impeding process ameliorating disorders....

The study aims to optimize cellulase (CMCase) production by Aspergillus flavus using wheat straw, an abundantly available lignocellulosic waste, as a substrate. Three parameters, i.e., nitrogen content (0.25 1%), fungal inoculum and duration (3 12 days), were optimized for maximum CMCase Response surface methodology-Box Behnken design (RSM-BBD). quadratic response was suitable, the model significant. However, higher-order machine learning (ML) models applied RSM-BBD had low R2 value (0.85)...

Lipoic acid (LA) and dihydrolipoic (DHLA) are well established antioxidants to scavenge reactive oxygen species (ROS). However, they carboxylates with ≈4.7 pKa making them negatively charged at physiological pH (7.4) reducing their passive diffusion through cell membranes. LA is known be capable of protein fibrillation. Incorporation especially DHLA in polymer side chains scarce. Herein, the first examples anti-amyloidogenic effect incorporated into side-chain a block copolymer water-soluble...

Mor-HSA-NPs and EC-HSA-NPs are effective on MDA-MB-468 breast cancer cell lines.

Nanoencapsulation has emerged as a promising approach for the effective delivery of poorly aqueous soluble compounds. The current study focuses on preparation human serum albumin (HSA)-based nanoparticles (NPs) and poly lactic-co-glycolic acid (PLGA)-based morin-Cu(II) complex. NPs were analyzed based different parameters such particle size, surface charge, morphology, encapsulation efficiency, in vitro release properties. average sizes found to be 214 ± 6 nm Mor-Cu-HSA-NPs 185 7.5...

Insulin fibril formation is considered as the hallmark of several debilitating pathological conditions. To develop effective therapeutics that are able to control amyloidogenesis process and inhibit formation, herein we have designed a side-chain proline (Pro)-based homopolymer block copolymers through reversible addition-fragmentation chain transfer (RAFT) polymerization technique further explored their obligatory role in vitro insulin fibrillation process. Using variety biophysical tools,...

Abstract The design and development of side‐chain amino‐acid‐based polymeric nanostructures have attracted a significant research interest as they bring remarkable revolution in various territories the biomedical field. incorporation amino acid moieties into side chain synthetic scaffolds exhibits several beneficial properties like aqueous solubility, chiral recognition, high biocompatibility, stimuli responsiveness, antifouling properties, well their capability to form higher ordered...

To explore the impact of polymer-coated silver nanoparticles (PC-AgNPs) on extent insulin aggregation process, herein, we have synthesized three copolymers comprising poly(ethylene glycol) methyl ether methacrylate (PEGMA) and tert-butoxycarbonyl (Boc)-protected amino acid (alanine, leucine, phenylalanine) containing monomers, via reversible addition-fragmentation chain transfer (RAFT) polymerization. After deprotection Boc groups, as-prepared water-soluble were coated (Ag NPs), role these...

To address the obstacles in insulin protein homeostasis leading to formation of neurotoxic amyloid plaques associated with different diseases, herein we have synthesized block copolymers using reversible addition-fragmentation chain transfer (RAFT) polymerization method, composed tert-butoxycarbonyl (Boc) protected leucine and acetyl (Ac) glucose pendant moieties, respectively. Selective or dual deprotection Boc- Ac-groups from and/or moieties resulted amphiphilic polymers, which...

Developing effective amyloidosis inhibitors poses a significant challenge due to the dynamic nature of protein structures, complex interplay interfaces in protein–protein interactions, and irreversible amyloid assembly. The interactions amyloidogenic polypeptides with other peptides play pivotal role modulating fibril formation. This study presents novel approach for designing synthesizing interaction surfaces using segments derived from amyloid-promoting sequence β-peptide...

Understanding the interaction of proteins with nanoparticles has become an important area research in biomedical and pharmaceutical fields. Morin is a flavonol which shows several properties including antioxidant, anticancer, anti-inflammatory activities. However, major limitation its poor aqueous solubility. Therefore, morin-loaded polylactic-co-glycolic acid (PLGA) (MPNPs) were prepared to improve solubility morin. The resulting MPNPs characterized by spectroscopic microscopic techniques....

In recent decades, polymeric materials have been extensively investigated for their widespread therapeutic applications in various biomedical fields. particular, biomolecule conjugated polymers continue to draw attention due distinctive physicochemical and biological properties. By appending biomolecules on constructs, these synthetic macromolecules can be strategized as multimotive theranostic agents. this Review, we intend spotlight the of containing cholic acid (CA) biomolecular...