A5022184651- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Advanced Nanomaterials in Catalysis
- Free Radicals and Antioxidants
- Advanced Glycation End Products research
- Metal complexes synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Phytochemicals and Antioxidant Activities
- Supramolecular Chemistry and Complexes
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- COVID-19 epidemiological studies
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Chromatography
- Pickering emulsions and particle stabilization
- COVID-19 Pandemic Impacts
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Advanced Photocatalysis Techniques
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Nanocluster Synthesis and Applications
Indian Institute of Science Bangalore
2022-2024
National Institute of Technology Meghalaya
2017-2024
Global University
2024
University of Gour Banga
2024
Haldia Institute of Technology
2023
University of Kassel
2021
Bangladesh Agricultural University
2021
Chandigarh University
2021
Indian Institute of Management Shillong
2018-2019
A new strain of a novel infectious disease affecting millions people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as pandemic the World Health Organization (WHO). Currently, several clinical trials are underway to identify specific drugs for treatment this virus. The inhibition SARS-CoV-2 main protease is necessary blockage viral replication. Here, in study, we have utilized blind molecular docking approach possible inhibitors protease,...
The binding of two bio-active flavonoids, quercetin and rutin, with bovine hemoglobin (BHb) was investigated by multi-spectroscopic computational (molecular docking molecular dynamics simulation) studies. flavonoids were found to quench the intrinsic fluorescence BHb through a static quenching mechanism. constants at 288 K observed be (14.023 ± 0.73) × 104 M-1 (7.848 0.20) M-1, respectively for rutin BHb. Both increase polarity around Trp residues as indicated synchronous 3D spectral No...
In the proposed work, complexation of bioactive flavonoid luteolin with hen egg white lysozyme (HEWL) along its inhibitory influence on HEWL modification has been explored help multi-spectroscopic and computational methods. The binding affinity observed to be moderate in nature (in order 104 M-1) static quenching mechanism was found involved fluorescence process. constant (Kb) shows a progressive increase temperature from (4.075 ± 0.046 × at 293 K (6.962 0.024 313 under experimental...
(−)-Epigallocatechin gallate binds to BHb and exhibits anti-glycating as well antioxidant behaviors towards glycation photo-oxidation of BHb.
Green synthesis of silver nanoparticles (AgNPs) has garnered tremendous interest as conventional methods include the use and production toxic chemicals, products, by-products reagents. In this regard, AgNPs using green tea (GT) extract two its components, (-)-epigallocatechin gallate (EGCG) (+)-catechin (Ct) capping/stabilizing agents, is reported. The synthesized showed antibacterial activity against bacterial strains
The development of superior functional enzyme mimics (nanozymes) is essential for practical applications, including point-of-care diagnostics, biotechnological biofuels, and environmental remediation. Nanozymes with the ability to control their catalytic activity in response external fuels offer functionally valuable platforms mimicking nonequilibrium systems nature. Herein, we fabricated a supramolecular coordination bonding-based dynamic vesicle that exhibits multienzymatic activity....
The interaction of 6-hydroxyflavone (6HF) with hen egg white lysozyme (HEWL) has been executed using multi-spectroscopic and computational methods. Steady state fluorescence studies indicated that static quenching mechanism is involved in the binding 6HF HEWL, which was further supported by excited lifetime UV-vis absorption studies. constant (Kb) HEWL-6HF complex observed to be 6.44 ± 0.09 × 104 M-1 at 293 K, decreases increase temperature. calculation thermodynamic quantities showed...
Abstract In recent times, research based on the bio‐active flavonoid, chrysin has shown its potential therapeutic applications such as anti‐diabetic, neuroprotective, anti‐asthmatic, anti‐depressant, etc. order to understand molecular recognition process, we studied interaction with hen egg white lysozyme (HEWL) at physiological conditions. Chrysin (5,7‐Dihydroxyflavone) was able quench intrinsic fluorescence of HEWL through static quenching mechanism and binding constant ( K b ) found be...
In this study, we investigated the complexation of bioactive isoflavones, specifically biochanin A (BCA) and genistein (GEN), with hen egg white lysozyme (HEWL) explored their inhibitory effects on HEWL modification using a combination multi-spectroscopic computational methods. The observed binding affinity was moderate nature (on order 104 M−1), static quenching mechanism identified in fluorescence process. Notably, constant (Kb) for GEN (4.449±0.262 × M−1) found to be higher than that BCA...
The non-enzymatic glycation of plasma proteins by reducing sugars have important consequences on the conformational and functional properties protein. formation advanced end products (AGEs) is responsible for cell death other pathological conditions. We synthesized glycated human serum albumin (gHSA) characterized same using differential spectroscopic measurements. aim present study to determine effect binding (HSA) with bioactive flavonoid chrysin, which possesses anti-cancer,...
Regulation of enzyme activity and biocatalytic cascades on compartmentalized cellular components is key to the adaptation processes such as signal transduction metabolism in response varying external conditions. Synthetic molecular glues have enabled inhibition regulation protein-protein interactions. So far, all glue systems based covalent interactions operated under steady-state To emulate dynamic biological dissipative conditions, we introduce herein a transient supramolecular with...