A new strain of a novel infectious disease affecting millions people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as pandemic the World Health Organization (WHO). Currently, several clinical trials are underway to identify specific drugs for treatment this virus. The inhibition SARS-CoV-2 main protease is necessary blockage viral replication. Here, in study, we have utilized blind molecular docking approach possible inhibitors protease,...

In the proposed work, complexation of bioactive flavonoid luteolin with hen egg white lysozyme (HEWL) along its inhibitory influence on HEWL modification has been explored help multi-spectroscopic and computational methods. The binding affinity observed to be moderate in nature (in order 104 M-1) static quenching mechanism was found involved fluorescence process. constant (Kb) shows a progressive increase temperature from (4.075 ± 0.046 × at 293 K (6.962 0.024 313 under experimental...

A new strain of a novel infectious disease affecting millions people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as pandemic the World Health Organization (WHO). Currently, several clinical trials are underway to identify specific drugs for treatment this virus. The inhibition SARS-CoV-2 main protease is necessary blockage viral replication. Here, in study, we have utilized blind molecular docking approach possible inhibitors protease,...

(−)-Epigallocatechin gallate binds to BHb and exhibits anti-glycating as well antioxidant behaviors towards glycation photo-oxidation of BHb.

A new strain of a novel infectious disease affecting millions people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as pandemic the World Health Organization (WHO). Currently, several clinical trials are underway to identify specific drugs for treatment this virus. The inhibition SARS-CoV-2 main protease is necessary blockage viral replication. Here, in study, we have utilized blind molecular docking approach possible inhibitors protease,...

The non-enzymatic glycation of plasma proteins by reducing sugars have important consequences on the conformational and functional properties protein. formation advanced end products (AGEs) is responsible for cell death other pathological conditions. We synthesized glycated human serum albumin (gHSA) characterized same using differential spectroscopic measurements. aim present study to determine effect binding (HSA) with bioactive flavonoid chrysin, which possesses anti-cancer,...

Flavonoids are significant dietary components and have ability to coordinate with metal ions produce novel drug discovery leads that superior those of the parent flavonoids. Here, in this report, we synthesized chrysin-Cu(II) complex (as per reported article) characterized it further different analytical techniques. The was evaluated for radical scavenging cell cytotoxicity studies where exhibited enhanced activity as compared bare chrysin. interaction ct-DNA (Kb ⁓ 105 M−1), human serum...

Ovalbumin (OVA), the major component of egg white, has been used as a model carrier protein to study interaction four bioactive phytochemicals 6-hydroxyflavone, chrysin, naringin, and naringenin. A static quenching mechanism was primarily associated with complexation flavonoids OVA. Hydrophobic forces play part in stability complexes. The structural changes within response flavonoid binding revealed decrease OVA's α-helical content. hypothesized site for OVA overlaps one or more...

Different post-translational changes in eye lens crystallin proteins contribute towards the development of cataract. We have studied vitro oxidative modification tryptophan (Trp) residues human γD-crystallin (HGD) formation N-formylkynurenine (NFK) associated with cataractogenesis. This oxidation was found to be inhibited by quercetin at relatively low concentration. Interactions between and HGD were further using fluorescence techniques. Binding quenching constants determined as ∼104 M−1....

<p>The dissemination of a novel corona virus, SARS-CoV-2, through rapid human to transmission has led global health emergency. The lack vaccine or medication for effective treatment this disease made it imperative developing drug discovery approaches. Repurposing drugs is one such method currently being used tackle the viral infection. genome SARS-CoV-2 replicates due functioning main protease called M<sup>pro</sup>. By targeting active site M<sup>pro</sup> with...

Kaempferol can be used as a multi-wavelength fluorescent probe due to its dual emission characteristics in serum albumin environment.

The dissemination of a novel corona virus, SARS-CoV-2, through rapid human to transmission has led global health emergency. lack vaccine or medication for effective treatment this disease made it imperative developing drug discovery approaches. Repurposing drugs is one such method currently being used tackle the viral infection. genome SARS-CoV-2 replicates due functioning main protease called M pro . By targeting active site with potential inhibitors, could prevent replication from taking...

Interactions between bovine γ-globulin (BGG) and borohydride-capped silver nanoparticles (BAgNPs) were studied using dynamic light scattering (DLS) spectroscopic techniques such as UV-vis spectroscopy, fluorescence, circular dichroism. The results compared with earlier reported interactions citrate-coated AgNPs (CAgNPs). BAgNPs synthesized characterized. Irrespective of the coating on AgNPs, had formed ground-state complexes protein. CAgNPs, well caused static quenching tryptophan (Trp)...

Abstract A facile method for the synthesis of 2,2‐disubstituted‐2 H ‐1‐benzopyrans from easily accessible tertiary propargylic alcohols and phenolic derivatives is described using a sulfonated tetraphenylethylene‐based hypercrosslinked polymer (THP‐SO 3 H) as heterogeneous organocatalyst. The organocatalyst can be recovered by filtration reused up to five consecutive cycles with nominal loss in catalytic efficiency. binding interaction synthesized benzopyrans human serum albumin was...