A5103162770- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Protein Hydrolysis and Bioactive Peptides
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
- Adenosine and Purinergic Signaling
- Toxin Mechanisms and Immunotoxins
- Vibrio bacteria research studies
- Neurobiology and Insect Physiology Research
- Viral gastroenteritis research and epidemiology
- Tryptophan and brain disorders
- Genomics and Rare Diseases
- Lymphoma Diagnosis and Treatment
- Salmonella and Campylobacter epidemiology
- Free Radicals and Antioxidants
- Diverse Scientific Research Studies
- Cystic Fibrosis Research Advances
- Insect Utilization and Effects
- Protein Interaction Studies and Fluorescence Analysis
Nanyang Technological University
2025
Tezpur University
2018-2023
The binding of two bio-active flavonoids, quercetin and rutin, with bovine hemoglobin (BHb) was investigated by multi-spectroscopic computational (molecular docking molecular dynamics simulation) studies. flavonoids were found to quench the intrinsic fluorescence BHb through a static quenching mechanism. constants at 288 K observed be (14.023 ± 0.73) × 104 M-1 (7.848 0.20) M-1, respectively for rutin BHb. Both increase polarity around Trp residues as indicated synchronous 3D spectral No...
Abstract We performed an initial assessment of 24 missense POT1 variants using variant effect predictors (VEPs) followed by extensive molecular dynamics (MD) simulations 14 selected variants: N-terminal - I115T, Y223C, D224N, M251V, H266Q, S270N, C-terminal A364E, P371T, T416A, S421L, A532P, L538V, P601L, Q623H for the unbound state and bound with telomeric ssDNA (N-terminal) or TPP-PBD (C-terminal). Wet-lab validations electrophoretic mobility shift assay (EMSA), telomere...
Abstract Visceral leishmaniasis affects millions of people worldwide in areas where Leishmania donovani is endemic. The protozoan species serves a greater threat as it has gradually evolved drug resistance whereby requiring newer approaches to treat the infection. State‐of‐art techniques are mostly directed toward finding better targets extracted from available proteome data. In light recent computational advancements, we ascertain and validate one such target, adenylosuccinate lyase ( ADSL...
The protozoan Leishmania donovani, from trypanosomatids family is a deadly human pathogen responsible for causing Visceral Leishmaniasis. Unavailability of proper treatment in the developing countries has served as major threat to people. absence vaccines made possibilities rely solely over chemotherapy. Also, reduced drug efficacy due emerging resistant strains magnifies threat. Despite years formulations an effective therapy, complexity disease also unfortunately increasing. Absence...
Abstract Saturated free fatty acid-induced adipocyte inflammation plays a pivotal role in implementing insulin resistance and type 2 diabetes. Recent reports suggest A2A adenosine receptor (A2AAR) could be an attractive choice to counteract resistance. Thus, effective A2AAR agonist devoid of any toxicity is highly appealing. Here, we report that indirubin-3′-monoxime (I3M), derivative the bisindole alkaloid indirubin, efficiently binds activates which leads attenuation lipid-induced Using...