A facile route to well-defined "smart" polymer-protein conjugates with tunable bioactivity is reported. Protein modification a reversible addition-fragmentation chain transfer (RAFT) agent and subsequent room temperature polymerization in aqueous media led of poly(N-isopropylacrylamide) model protein. Representing the first example conjugation RAFT immobilization via "R-group" approach, high molecular weight reductively stable were accessible without extensive purification or adverse effects...

The recent advances achieved in the study of various stimuli-responsive polymers derived from natural amino acids have been reviewed.

Abstract End group activation of polymers prepared by reversible addition‐fragmentation chain transfer (RAFT) polymerization was accomplished conversion thiocarbonylthio end groups to thiols and subsequent reaction with excess a bismaleimide. Poly( N ‐isopropylacrylamide) (PNIPAM) RAFT, aminolysis led sulfhydryl‐terminated that reacted an 1,8‐bismaleimidodiethyleneglycol yield maleimido‐terminated macromolecules. The maleimido allowed near‐quantitative coupling model low molecular weight or...

Abstract Responsive polymer‐protein conjugates were synthesized by combination of reversible addition‐fragmentation chain transfer (RAFT) polymerization and a grafting‐to approach highly efficient “click chemistry” strategy. A model protein, bovine serum albumin (BSA), was functionalized with an alkyne moiety reaction its free cysteine residue propargyl maleimide. Azido‐terminated poly( N ‐isopropylacrylamide) (PNIPAM‐N 3 ) prepared via RAFT, coupling accomplished copper‐catalyzed...

A combination of controlled radical polymerization and azide−alkyne click chemistry was employed to prepare temperature-responsive block copolymer micelles conjugated with biological ligands potential for active targeting cancer tissues. Block copolymers N-isopropylacrylamide (NIPAM) N,N-dimethylacrylamide (DMA) were synthesized by reversible addition−fragmentation chain transfer (RAFT) an azido agent (CTA). Pseudo-first-order kinetics linear molecular weight dependence on conversion...

Well-defined temperature-responsive polymers were covalently conjugated to model proteins by two consecutive Michael addition thiol–ene reactions. Poly(N-isopropylacrylamide) (PNIPAM) prepared reversible addition–fragmentation chain transfer (RAFT) polymerization was aminolyzed yield thiol-terminated chains that subsequently reacted with excess 1,8-bis-maleimidodiethyleneglycol. The resulting maleimide-terminated polymer bovine serum albumin and ovalbumin polymer–protein conjugates a...

Detection of nitroaromatic explosives with high sensitivity and selectivity is extremely important for civilian military safety. Here, we report the synthesis multimodal sensing applications an emissive alanine based dansyl tagged copolymer P(MMA-co-Dansyl-Ala-HEMA) (DCP), synthesized by RAFT copolymerization. The fluorescent co-polymer exhibited towards conventional such as DNT, TNT TNP in solution at lower range µM level also saturated vapor NACs. quantum yield was measured to be very (Φf...

Unprecedented photoluminescence, AIE and heat-induced emission characteristics of non-conjugated thermoresponsive PNVCL were unveiled for the very first time which eventually empowered to act as an intracellular thermometer.

Recently, nonconventional luminescent polymers (NLPs) have emerged as the most sought-after alternative materials. This review provides a thorough description of importance and applications each class state-of-the-art NLPs.

To design versatile ordered nanomorphologies from the alternating sequence-controlled amphiphilic copolymers, in current work, we have investigated self-assembly behavior of a series prepared through reversible addition–fragmentation chain transfer (RAFT) polymerization methoxy poly(ethylene glycol) (mPEG) functionalized styrene (VBP) and fatty acid attached maleimide (MF) monomers. The copolymers efficiently induced self-aggregation pendant side chains to afford both micelle vesicle...

Lysine and fatty acid-tethered amphiphilic copolymers exhibited potent antibacterial activity against Gram-positive ( B. subtilis ) Gram-negative E. coli bacteria with side chain degradability in the presence of an enzyme pH.

Well-defined homopolymers and block copolymers with boronic acid-functional end groups were prepared by reversible addition−fragmentation chain transfer (RAFT) polymerization subsequently investigated for the potential to undergo model supramolecular dynamic covalent self-assembly in aqueous organic media. By employing a acid-functionalized RAFT agent, end-functional polymers without recourse postpolymerization functionalization. The polymerizations of styrene, N,N-dimethylacrylamide,...

Abstract Well‐defined “smart” block copolymer–protein conjugates were prepared by two consecutive “grafting‐from” reactions via reversible addition–fragmentation chain transfer (RAFT) polymerization. The initiating portion (R‐group) of the RAFT agent was anchored to a model protein such that thiocarbonylthio moiety readily accessible for with propagating chains in solution. polymer‐protein poly( N ‐isopropylacrylamide) (PNIPAM) and bovine serum albumin (BSA) at room temperature aqueous...

Two methacrylate containing amino acid based chiral monomers, Boc-L-alanine methacryloyloxyethyl ester (Boc-Ala-HEMA) and Boc-L-phenylalanine (Boc-Phe-HEMA), were polymerized by the reversible addition–fragmentation chain transfer (RAFT) process to afford well-defined polymers with controlled molecular weight, narrow weight distribution, precise end structure. Linear pseudo-first-order kinetics number average dependence on conversion observed for RAFT polymerizations. Di-block copolymers...

ABSTRACT Design and synthesis of pH responsive polymeric materials has become an important subject in academia as well industrial field recent years due to their applications diverse including controlled drug delivery, biomedical applications, membrane science, sensors actuators, oil recovery, colloid stabilization, etc. Efforts have been made incorporate stimuli‐responsive biomolecules synthetic polymers develop “smart” non‐biological hybrid macromolecules with high water solubility,...

Leucine/isoleucine side chain polymers are of interest due to their hydrophobicity and reported role in the formation α-helical structures. The synthesis reversible addition-fragmentation transfer (RAFT) polymerization amino acid-based chiral monomers, namely Boc-L-leucine methacryloyloxyethyl ester (Boc-L-Leu-HEMA, 1a), acryloyloxyethyl (Boc-L-Leu-HEA, 1b), Boc-L-isoleucine (Boc-L-Ile-HEMA, 1c), (Boc-L-Ile-HEA, 1d), reported. controlled nature said monomers N, N-dimethylformamide (DMF) at...

Here we report the design and synthesis of polymers containing cholic acid pendant groups, a major bile synthesized in liver from cholesterol. Random copolymers derived 2-(methacryloyloxy)ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA) N,N-dimethylaminoethyl (DMAEMA) have been by reversible addition–fragmentation chain transfer (RAFT) polymerization. Compositions co-monomers were determined 1H NMR spectroscopy, which further used to determine reactivity...

This work reports design and synthesis of side chain amino acid based cross-linked polymeric gels, able to switch over from organogel hydrogel by a simple deprotection reaction showing superabsorbancy in water. Amino methacrylate monomers, tert-butoxycarbonyl (Boc)-l/d-alanine methacryloyloxyethyl ester (Boc-l/d-Ala-HEMA), have been polymerized the presence cross-linker via conventional free radical polymerization (FRP) reversible addition-fragmentation transfer (RAFT) technique for polymer...

This work demonstrates the successful application of dynamic covalent chemistry for construction self-healing gels from side-chain primary amine leucine pendant diblock copolymers polyisobutylene (PIB) ((P(H2N-Leu-HEMA)-b-PIB)) in presence PIB based dialdehyde functionalized cross-linker (HOC–PIB–CHO) through imine (−HC═N−) bond formation without aiding any external stimuli. Gels were synthesized 1,4-dioxane at room temperature varied wt % gelator concentration, [H2N]/[CHO] ratios and...

A conventional fluorophore-free water-soluble copolymer based on poly(styrene-<italic>alt</italic>-maleimide) has been found to be selective and sensitive detection of picric acid in a 100% aqueous environment with prompt response.

Protein misfolding and aggregation have attracted immense research interests due to their connection with an array of degenerative diseases including neurodegenerative disorders non-neuropathic diseases. Inhibition or diminution the formation protein aggregates is considered as a potential therapeutic strategy cure these debilitating maladies. A large number compounds flavonoids, surfactants, osmolytes, vitamins, nanoparticles, etc. been explored for impeding process ameliorating disorders....

Abstract To develop glutamic acid derived cross‐linked polymeric organogels for dye adsorption from aqueous media, dimethyl 2‐(methacrylamido)pentanedioate (Glu‐MAC) is polymerized using diethylene glycol dimethacrylate as cross‐linker via the reversible addition‐fragmentation chain transfer (RAFT) technique to synthesize with pendant glutamate moieties. The mechanical properties of are examined by rheological study. exhibit higher value storage modulus ( G ′) than loss ′′) within linearity...

A series of copolymers with controlled monomer sequences are prepared via the reversible addition–fragmentation chain transfer polymerization tert-butyl carbamate (Boc)-l-alanine (VBA) and Boc-l-alanyl-l-leucine-conjugated styrenic (VBD) monomers l-alanine-appended maleimide (NMA). Monomer distribution in copolymer is examined by both 1H 13C NMR spectroscopy which eventually confirms an alternate placement different throughout polymer main copolymerization systems: VBA–NMA VBD–NMA. After...