A5086906851- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Glycosylation and Glycoproteins Research
- Osteoarthritis Treatment and Mechanisms
- Advanced Drug Delivery Systems
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Transgenic Plants and Applications
- Dyeing and Modifying Textile Fibers
- Drug Solubulity and Delivery Systems
- Supramolecular Self-Assembly in Materials
- Dental materials and restorations
- Pancreatic function and diabetes
- Polymer Surface Interaction Studies
- Surgical Sutures and Adhesives
- Dental Implant Techniques and Outcomes
- Wound Healing and Treatments
- Herbal Medicine Research Studies
Presidency University
2023-2025
Indian Institute of Chemical Biology
2018-2025
Cincinnati Children's Hospital Medical Center
2018-2022
Indian Institute of Technology Kharagpur
2013-2018
University of Delhi
2001-2013
A novel stimulus-sensitive covalently cross-linked hydrogel derived from dextrin, N-isopropylacrylamide, and N,N′-methylene bis(acrylamide) (c-Dxt/pNIPAm), has been synthesized via Michael type addition reaction for controlled drug release application. The chemical structure of c-Dxt/pNIPAm confirmed through Fourier transform infrared (FTIR) spectroscopy 1H 13C NMR spectral analyses. surface morphology the studied by field emission scanning electron microscopic (FE-SEM) environmental (E-SEM)...
We report on the synthesis and characterization of a novel hydrogel based dextrin grafted with poly(2-hydroxyethyl methacrylate) by embedding N,N′-methylene bis acrylamide (MBA) as cross linker, into polymeric network in presence potassium persulphate (KPS) initiator for colon specific delivery ornidazole. Various grades hydrogels [Dxt-g-p(HEMA)] have been synthesized altering reaction parameters best one optimized. The developed has characterized using FTIR spectra, 13C NMR elemental...
Herein, novel biodegradable, stimulus-responsive, chemically cross-linked and porous hydrogel has been synthesized to evaluate its applicability as an efficient carrier for sustained release of ornidazole ciprofloxacin. The (c-Dxt/pAA) developed from dextrin poly(acrylic acid) using N,N′-methylene bis(acrylamide) cross-linker via Michael-type addition reaction. With the variation reaction parameters, various c-Dxt/pAA hydrogels have optimize best one. characterized physicochemical...
Regeneration of full-thickness wounds without scar formation is a multifaceted process, which depends on in situ dynamic interactions between the tissue-engineered skin substitutes and newly formed reparative tissue. However, majority used so far wound healing cannot mimic natural extracellular matrix (ECM) complexity thus are incapable providing suitable niche for endogenous tissue repair. Herein, we demonstrated simple approach to fabricate porous hybrid ECM sponges (HEMS) using placental...
Herein, we report the development and application of a novel biocompatible, chemically crosslinked nanogel for use in anticancer drug delivery.
Placental extracellular matrix for osteochondral defects.
Most polymeric nanofibers used for bone tissue engineering lack adequate functional groups bioactivity. This study explores the potential of phosphate functionalized derivative chitosan-N-methylene phosphonic chitosan (NMPC) engineering. Nanofibers were fabricated by electrospinning NMPC/PVA blend solutions. exhibited 172% higher viability MG-63 cells compared to pure PVA nanofibers. ALP and Collagen type I genes revealed expression in NMPC on day 3 whereas osteocalcin gene was expressed 7....
Herein, we report a novel route for the synthesis of poly(acrylamide) (PAAm) crosslinked hydroxypropyl methyl cellulose/Au nanocomposite where chemically HPMC (c-HPMC) works as reducing agent.
Chitosan fibers were fabricated <italic>via</italic> pH induced neutralization and precipitation in a 5 w/v% NaOH bath.
Most living tissues are viscoelastic in nature. Self-repair due to the dissipation of energy by reversible bonds prevents rupture molecular backbone these tissues. Recent studies, therefore, have aimed synthesize biomaterials that approximate mechanical performance biological materials with self-recovery properties. We report an environmentally friendly method for development ionotropically cross-linked chitosan gels a modulus comparable The strain recovery property was found be highest...
Low strength and rapid biodegradability of acellular dermal matrix (ADM) restrict its wider clinical application as a cell delivery platform in situ for management burn wounds. Herein, the extracted ADM was modified by dual cross-linking approach with ionic crosslinking using chitosan covalent an iodine-modified 2,5-dihydro-2,5-dimethoxy-furan cross-linker, termed CsADM-Cl. In addition, inherent growth factors cytokines were found to be preserved CsADM-Cl, irrespective ionic/covalent...
Abstract Timely control of bleeding is crucial to reduce mortality in traumatic injuries, highlighting the urgent need for biomaterials with anti‐hemorrhagic properties. Polycaprolactone (PCL) commonly used producing nanofibers range 100–200 nm. However, creating ultrafine PCL diameters below 100 nm remains a challenge, limiting its potential as hemostatic bandage. In this study, various ratios low molecular weight are blended reduced keratin modulate solution shear‐thinning behavior. The...
Radiopaque polymer derivatives were successfully prepared through surface diffusion mediated cross-linking of chitosan with iodinated 2,5-dimethoxy-2,5-dihydrofuran. The incorporation iodine in 2,5-dimethoxy-2,5-dihydrofuran was validated by (1)H NMR and mass spectroscopy. the glucosamine moieties product confirmed (13)C energy-dispersive X-ray Radiography analysis proved inherent opacity fibrous sheets microspheres that comparable to visibility aluminum hollow rings equivalent thickness...
In this study, articular cartilage was decellularized preserving a majority of the inherent proteins, cytokines, growth factors and sGAGs. The matrix (dCM) then encapsulated in poly(lactic acid) microspheres (MS + dCM) via double emulsion. Blank without dCM, MS(-), were also produced. spherical shape protein encapsulation efficiency within MS dCM 63.4%. sustained release proteins from observed over 4 weeks vitro. Both MS(-) cytocompatible. delivery retained cytokines promoted cell migration...
The purpose of the study is to develop a method imparting radio-opacity silk fibers by stepwise 2,5-dimethoxy-2,5-dihydro-furan (DMDF)–iodine cross-linking reaction for suture fabrication with mechanical properties abiding U.S. pharmacopeia guidelines along non invasive imaging advantage in postoperative follow-up. Silk isolated from Bombyx mori were cross-linked suitable concentration DMDF linked iodine under elevated temperature and pressure. Cross-linked knitted into sutures subjected...
In recent years, the extraction of bioresources from biowaste via green chemistry and their utilization for production materials has gained global momentum due to growing awareness concepts sustainability. Herein, we report a benign process using an ionic liquid (IL), 1-butyl-3-methylimidazolium chloride ([BMIM]Cl), simultaneous keratin melanin human hair. Chemical characterization, secondary structure studies, thermal analysis regenerated protein were performed thoroughly. Hemolytic...