A5021100961- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Hip disorders and treatments
- Electrospun Nanofibers in Biomedical Applications
- Diatoms and Algae Research
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Additive Manufacturing and 3D Printing Technologies
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Blood properties and coagulation
- 3D Printing in Biomedical Research
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Bone and Joint Diseases
- 14-3-3 protein interactions
- Ubiquitin and proteasome pathways
- Shoulder and Clavicle Injuries
- Osteoarthritis Treatment and Mechanisms
- Nerve Injury and Rehabilitation
Cincinnati Children's Hospital Medical Center
2015-2025
University of Cincinnati Medical Center
2019-2024
University of Cincinnati
2005-2024
University of Groningen
2022
Wake Forest University
2007-2019
University of Bern
2014
Drexel University
2008
Forest Institute
2007
Duke Medical Center
2005
Polymer Research Center
2002
Herein we describe the controlled formation of biosilica structures by manipulation physical reaction environment; were able to synthesize arched and elongated silica using a synthetic peptide; results presented here are evidence that in vitro biocatalysis may be order form desired structures.
Background: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but limited supply and its harvest imparts significant morbidity to patient. Alternative sources graft include allografts, synthetics and, less commonly, xenografts which taken from animal species. Xenografts available unlimited healthy donors with controlled biology, avoiding risk human disease transmission, may satisfy current demand for products....
Background: Stable slipped capital femoral epiphysis (SCFE) is often considered semi-urgent, prompting admission for in situ screw fixation (ISF), which may increase the cost/burden of care. Avascular necrosis (AVN) affects 25% to 50% patients with unstable SCFE, yet it uncommon after stable SCFE. Among presenting little known about relationship between diagnosis and surgical timing regard slip progression or complications. Methods: This retrospective observational study included all younger...
Abstract The current study determined the dose–response relationship for inhibition of muscle force two commercially available botulinum neurotoxin type‐A (BoNTA) preparations (Botox® and Neuronox®) in a murine model characterized time course recovery from toxin‐induced paralysis. effect freezing reconstituted toxin on potency was also determined. gastrocnemius muscles male CD‐1 mice were injected with either saline or BoNTA (0.3–3.0 U/kg), generation examined following stimulation tibial...
Surgical repair of large chronic rotator cuff tears can be technically demanding because it requires manipulation a muscle-tendon unit that is scarred, retracted, and stiffer than normal, all which contribute to increased tension at the site. The purpose present study was characterize in vivo function after acute injury surgically relevant preload tensions.Sixty-two Sprague-Dawley rats were divided into healthy, uninjured (control) group (n = 22), an 20), 20) underwent muscle force testing...
This study evaluated the properties of scaffold derived from freeze-dried human Achilles tendon allograft for use in anterior cruciate ligament (ACL) reconstruction. Our hypothesis was that such an could be processed using a method to remove cellular and infectious material, producing cytocompatible, architecturally modified possessing tensile suitable ACL reconstruction.Fifty-two allografts were provided by tissue bank. Twenty-one used as controls assess cellularity, DNA content,...
Bone grafting is the second most common tissue transplantation procedure worldwide. One of alternative methods for bone repair under investigation a tissue-engineered substitute. An ideal property substitutes osteoinductivity, defined as ability to stimulate primitive cells differentiate into bone-forming lineage. In current study, we use decellularization and oxidation protocol produce porcine scaffold examine whether it possesses osteoinductive potential can be used create...
Introduction: Osteochondral lesions of the femoral head in young patients are a rare but challenging clinical problem. Fresh osteochondral allograft (OCA) transplantation has been proposed as one potential treatment option that may improve function and delay hip arthroplasty. However, there is paucity published data. The purpose this study was to assess survivorship patient-reported outcomes undergoing OCA for head. Methods: Sixteen (16 hips) who underwent avascular necrosis between 1985...
Background: Optimal management for a pulseless supracondylar humerus fracture associated with anterior interosseous nerve (AIN) or median injury is unclear. The purpose of this study was to determine the incidence fractures AIN injury, assess open versus closed surgical management, factors need neurovascular intervention, and report outcome. Methods: A retrospective review performed at 4 pediatric trauma hospitals on all patients who sustained Gartland III IV combination absent distal...
Abstract Background Xenografts are an attractive alternative to traditional bone grafts because of the large supply from donors with predictable morphology and biology as well minimal risk human disease transmission. Clinical series involving xenograft transplantation, most commonly bovine sources, have reported poor results frequent graft rejection failure integrate host tissue. Failures been attributed residual alpha‐Gal epitope in which humans produce natural antibody against. To authors'...
In this study, articular cartilage was decellularized preserving a majority of the inherent proteins, cytokines, growth factors and sGAGs. The matrix (dCM) then encapsulated in poly(lactic acid) microspheres (MS + dCM) via double emulsion. Blank without dCM, MS(-), were also produced. spherical shape protein encapsulation efficiency within MS dCM 63.4%. sustained release proteins from observed over 4 weeks vitro. Both MS(-) cytocompatible. delivery retained cytokines promoted cell migration...