A5000005453- Blood properties and coagulation
- Platelet Disorders and Treatments
- Biomedical Ethics and Regulation
- 14-3-3 protein interactions
- Autoimmune and Inflammatory Disorders Research
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Childhood Cancer Survivors' Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Streptococcal Infections and Treatments
- Parvovirus B19 Infection Studies
- Cardiac Arrest and Resuscitation
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Cardiac and Coronary Surgery Techniques
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cancer-related gene regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Adolescent and Pediatric Healthcare
Icahn School of Medicine at Mount Sinai
2024
Cincinnati Children's Hospital Medical Center
2018-2024
University of Cincinnati
2021-2024
Ospedale Papa Giovanni XXIII
2023
Pediatrics and Genetics
2022
University of Cincinnati Medical Center
2019-2021
Stanford Medicine
2012
Stanford University
2012
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that most commonly treated with etoposide and dexamethasone. This standard of care therapy has improved survival, but ∼15% patients still die in the first months after diagnosis, poor responses prompting salvage are frequent. Thus, identifying at risk promptly likely to improve outcomes. We conducted multi-institutional, retrospective study pediatric young adults per HLH-94 or HLH-2004 from 2010 2019...
Abstract Background Evidence for aspirin efficacy testing in pediatrics is limited, especially outside of cardiology, yet thrombotic events have high morbidity other areas such as pediatric transplant surgery. Debates about whether thromboembolic while on represent “aspirin resistance” or “high on‐treatment platelet reactivity” persist, given the poor intertest agreement between platforms. Procedure This prospective observational study involved measuring using ex vivo aggregation...
Table 1: Hematological parameters of Townes mice transduced with 1 × 1014 vg/kg rAAV8-mHPX vector or control vector.Results shown as median and interquartile range (IQR); n = 16 rAAV8-mHPX; 10 rAAV8-Empty.*Mann-Whitney test Unpaired T test. Conclusion(s):While long-term gene transfer HPX is feasible in C57BL/6 mice, achievement therapeutic levels an animal model SCA challenging, possibly due to consumption.Additional experiments are required explore whether transgenic expression can result...