A5054081350- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Diabetes Management and Research
- Childhood Cancer Survivors' Quality of Life
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gallbladder and Bile Duct Disorders
- Diabetes and associated disorders
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Renal Transplantation Outcomes and Treatments
- Clinical Nutrition and Gastroenterology
- Neuroendocrine Tumor Research Advances
- Hemoglobinopathies and Related Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Adolescent and Pediatric Healthcare
- Neuropeptides and Animal Physiology
- Cystic Fibrosis Research Advances
- Organ Donation and Transplantation
- Cannabis and Cannabinoid Research
Nationwide Children's Hospital
2018-2025
The Ohio State University
2018-2025
Temple University Hospital
2025
Cincinnati Children's Hospital Medical Center
2015-2024
University of Chicago
2023
University of Cincinnati
2010-2023
University of Cincinnati Medical Center
2014-2023
Nationwide Mutual Insurance Company (United States)
2022-2023
The Ohio State University Wexner Medical Center
2022-2023
Johns Hopkins University
2023
Abstract Cystic fibrosis (CF) is a genetic disorder caused by defective CF Transmembrane Conductance Regulator (CFTR) function. Insulin producing pancreatic islets are located in close proximity to the duct and there possibility of impaired cell-cell signaling between ductal epithelial cells (PDECs) islet as causative CF. To study this possibility, we present an vitro co-culturing system, pancreas-on-a-chip. Furthermore, efficient method micro dissect patient-derived human ducts from remnant...
ABSTRACT Objectives: The aim of the present study was to investigate natural history chronic pancreatitis (CP); patients in North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared. Methods: Demographics, risk factors, disease duration, management outcomes 224 children 1063 adults compared using appropriate statistical tests categorical continuous variables. Results: Alcohol 53% 1% ( P...
The outcomes of hepatic undifferentiated embryonal sarcoma (HUES) have historically been limited by persistent, unresectable disease and the subsequent development resistance dissemination. We present our institutional experience with HUES assess current treatment trends in era liver transplantation. conducted a retrospective chart review cases presenting at institution over past 10 years. collected data included age, sex, symptoms, imaging associated Pretreatment Extent Disease (PRETEXT)...
ABSTRACT Objective: Research is lacking on the natural history of acute pancreatitis (AP) progression to recurrent (ARP). The aim this project was study from AP ARP among pediatric patients with better understand presentation and pancreatitis. Methods: Patients presenting were included in a prospective database Electronic Data Capture. We enrolled 115 March 2013 November 2016. Physicians completed surveys regarding clinical data for first attack AP. followed prospectively, entered when...
The aim of the study was to determine rate progression from acute recurrent pancreatitis (ARP) chronic (CP) in children and assess risk factors.Data were collected INternational Study group Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) cohort. Kaplan-Meier curves constructed calculate duration initial attack (AP) CP. Log-rank test used compare survival (nonprogression) probability distribution between groups. Cox proportional hazard regression models fitted obtain ratio (with 95%...
We examined whether the capsaicin vanilloid receptor-1 (VR1) mediates substance P (SP) release from primary sensory neurons in experimental pancreatitis. Pancreatitis was achieved by 12 hourly injections of caerulein (50 microg/kg ip) mice. One group received capsazepine (100 micromol/kg sc), a competitive VR1 antagonist, at 4-h intervals. Neurokinin-1 receptor (NK1R) internalization acinar cells, used as an index endogenous SP release, assessed immunocytochemical quantification NK1R...
We hypothesized that neurogenic inflammation is a common final pathway for parenchymal in pancreatitis and evaluated the role of primary sensory neurons secretagogue-induced obstructive pancreatitis. Neonatal rats received either neuron-denervating agent capsaicin (50 mg/kg s.c.) or vehicle. At 8 wk age, was produced by six hourly injections caerulein microg/kg i.p.) pancreaticobiliary duct ligation (CPBDL). The severity assessed serum amylase, pancreatic myeloperoxidase (MPO) activity,...
Portal vein thrombosis (PVT) occurs in ≤12% of pediatric recipients liver transplantation (LT). Known complications PVT include portal hypertension, allograft loss, and mortality. The management is varied. A single-center, case-control study LT with (PV) changes after was performed. Cases were categorized as early (if detected within 30 days transplantation) or late more than if persisted beyond days). Two non-PVT control patients matched on the basis recipient weight, transplant indication,...
The significance of pancreas divisum (PD) as a risk factor for pancreatitis is controversial. We analyzed the characteristics children with PD associated acute recurrent or chronic to better understand its impact.We compared without in well-phenotyped INSPPIRE (INternational Study group Pediatric Pancreatitis: In search cuRE) cohort. Differences were using 2-sample t test Wilcoxon rank sum continuous variables, Pearson χ Fisher exact categorical variables.PD was found 52 359 (14.5%)...
We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study risk factors, natural history, and outcomes pediatric acute recurrent pancreatitis chronic (CP). Patient physician questionnaires collect information on demographics, clinical family social disease outcomes. Health-related quality life, depression, anxiety are measured using validated questionnaires. Information entered paper is transferred into database managed by Consortium...
The natural course of patients who develop acute pancreatitis (AP) can range from mild to severe (SAP). aim this study was evaluate for early predictors developing SAP during the first episode AP in a prospective pediatric cohort.Clinical data were prospectively collected and subsequently analyzed presenting with their between March 2013 January 2017 Cincinnati Children's Hospital Medical Center.A total 118 included analysis, 22 (18.6%) developed SAP. Patients had significantly higher values...
Post-ERCP pancreatitis (PEP) is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Limited existing data suggest that prophylactic pancreatic duct (PD) stenting in pediatric patients may increase risk PEP. The aim this study to identify factors associated with PEP patients.Patients at a single institution who underwent ERCP between 2012 and 2020 were retrospectively reviewed. Patient procedure-related collected. Data analyzed using Chi-square or Fisher...
Total pancreatectomy with islet autotransplantation (TPIAT) is used to treat debilitating chronic pancreatitis (CP) and acute recurrent (ARP) that has failed medical endoscopic therapy. We performed a retrospective review of TPIAT patients at free-standing children's hospital evaluate perioperative outcomes. Twenty (median age 13, 65% female) underwent (2015 through 2017). Of the 20 patients, 95% had CP 1 patient (5%) ARP alone. Seventy-five percent pancreatitis-associated genetic mutation;...