A5041618311- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Veterinary medicine and infectious diseases
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Phytochemistry and Bioactive Compounds
- Molecular Biology Techniques and Applications
- Eosinophilic Esophagitis
- Digestive system and related health
- Antimicrobial Resistance in Staphylococcus
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Gastrointestinal motility and disorders
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Health, Education, and Physical Culture
- Ocular Infections and Treatments
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Skin Diseases and Diabetes
- History of Education in Spain
- Seed and Plant Biochemistry
- Health and Lifestyle Studies
- Medical and Pharmaceutic Studies
University of Nariño
2014-2024
Universidad del Valle
2017-2024
Vanderbilt University Medical Center
2017
Ibero American University
2006-2007
Ibero-American University Puebla
2006-2007
Universidad Autónoma de Madrid
2006
Significance Theory predicts that chronic pathogens with vertical or familial transmission should become less virulent over time because of coevolution. Although transmitted in this way, Helicobacter pylori is the major causative agent gastric cancer. In two distinct Colombian populations similar levels H. infection but different incidences cancer, we examined human and pathogen ancestry matched samples to assess whether their genomic variation affects severity premalignant lesions....
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
AIMTo characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori (H.pylori ) and determine their association with therapeutic failure. METHODSPCR products V domain 74 H. isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, 5 high-risk Tuquerres-Colombia) 40 susceptible population (28 Tumaco 12 Túquerres) were sequenced using capillary electrophoresis.The concordance between failure was determined...
To compare the genomic variability and multiple colonization of Helicobacter pylori (H. pylori) in patients with chronic gastritis from two Colombian populations contrast risk developing gastric cancer (GC): Túquerres-Nariño (High risk) Tumaco-Nariño (Low risk).Four hundred nine both genders dyspeptic symptoms were studied. Seventy-two included whom H. was isolated three anatomic regions mucosa, (31/206) high population GC (Túquerres) (41/203) low (Tumaco). The isolates genotyped by...
The eradication of Helicobacter pylori is a valid strategy for preventing gastric cancer; however, the therapeutic failure first-line treatments in Colombia associated with high resistance to metronidazole and amoxicillin. This study explored alternative antibiotics analyzed point mutations genes furazolidone rifampicin order include them rescue therapy regimens. A total 239 complete genomes Colombian strains were compared that ATCC 26695 strain identify rpoB porD furazolidinone resistance,...
Introduction. Infection by Helicobacter pylori is prevalent in approximately half the world’s population. However, susceptibility of H. to antimicrobial agents must be evaluated vitro methods order determine levels and guide treatment regimes. Objective. The prevalence infection antibiotic was gastric biopsies containing pylori.Materials methods. investigated 203 patients with chronic gastritis from Tumaco, Colombia. Diagnosis confirmed histopathological evidence (Dixon scale)...
Infection by Helicobacter pylori is prevalent in approximately half the world´s population.However, susceptibility of H. to antimicrobial agents must be evaluated vitro methods order determine levels and guide treatment regimes.The prevalence infection antibiotic was gastric biopsies containing pylori.The investigated 203 patients with chronic gastritis from Tumaco, Colombia. Diagnosis confirmed histopathological evidence (Dixon scale) microbiological (culture on blood agar supplemented...
Introducción: El riesgo de desarrollar cáncer gástrico varía entre continentes, países y regiones. A pesar que existe una alta prevalencia Helicobacter pylori su rol como patógeno o mutualista define el en las regiones Colombia. Objetivo: Discutir Materiales métodos: Revisión literatura mediante la búsqueda, bases datos LILACS, SciELO, PubMed. Resultados: La coevolución del humano pylori; virulencia genes cagA, vacA; tipo respuesta inmune inflamatoria a (Th1) antinflamatoria (Th2)...
The eradication of Helicobacter pylori (H. pylori) using multiple therapies is used as a prevention strategy. However, its efficacy has been compromised by the emergence single nucleotide polymorphisms in genes associated with H. pylori's resistance to antibiotics. To estimate antibiotic rates mutations high-cancer-risk population Colombia, we included 166 whole genome sequences from cohort individuals high risk gastric cancer. By reference strain ATCC 26695, identified specific evaluate for...
Introducción. La inflamación del antro gástrico por Helicobacter pylori aumenta el riesgo de úlcera duodenal, y la cuerpo puede producir gastritis atrófica e incrementar probabilidad cáncer gástrico. Estas reacciones inflamatorias diferenciadas según su localización, podrían explicarse composición microbiota gástrica asociada con H. pylori.Objetivo. Identificar comparar estómago en individuos dos poblaciones: una alto otra bajo Nariño, Colombia.Materiales métodos. Se incluyeron biopsias...
To evaluate effect of treatment failure on cagA and vacA genotypes in Helicobacter pylori (H.pylori ) isolates from Colombia.
We sequenced the complete genomes of 16
Introducción: En Pasto-Nariño, Colombia, la incidencia de cáncer gástrico (CG) es una las más altas del mundo. patogénesis CG están implicados tanto los genes CYP1A1 y FNTα, como factores ambientales. La relación entre ambientales predisposición genética humana a CG, aún se desconoce. Objetivo: Evaluar asociación (Genes CYP1A1, FNTα) en pacientes con diagnóstico ciudad Pasto. Metodología:Estudio transversal, descriptivo observacional que incluyó 10 casos sobrevivientes diagnosticados CG. Se...
La infección por Helicobacter pylori (H. pylori) es dinámica en la población pediátrica, aumentando con edad. Existen varias pruebas diagnósticas disponibles y eficaces identificación de personas infectadas no infectadas, sin embargo, todavía necesaria una prueba invasiva, fiable tolerable niños. Objetivo: Estimar validez las H. niños Cali, Colombia. Pacientes Método: Se incluyeron 236 menores 10 años sintomáticos referidos a endoscopía digestiva alta para evaluación dolor...
ABSTRACT We present here the draft genomes of 13 Helicobacter pylori strains isolated from Colombian residents on Pacific coast ( n = 6) and in Andes mountains 7), locations that differ gastric cancer risk. These were obtained individuals with diagnosed lesions.
Introducción: la leche bovina es un producto de primera necesidad, con alto valor nutricional para población. Sin embargo, en el departamento Nariño, los estudios valorar su calidad son escasos. Objetivo: evaluar composicional, sanitaria y microbiológica cruda vacas Holstein mestizas Nariño. Métodos: se incluyeron 1056 muestras tomadas cada 15 días después del parto a 45 hembras. La composicional evaluó mediante densidad, punto crioscópico acidez por NTC4987, partir porcentajes grasa,...
no pasan la prueba de práctica.Quizás porque en este ámbito se vuelve a encontrar, aunque con matices específicos, el inconveniente mayor que estructuralismo plantea dominio estrictamente teórico: transformación formas materiales vida modos pensamiento.Los problemas práctica
Introducción: En producción avícola el uso de antibióticos promotores del crecimiento es limitado, debido al incremento resistencia bacteriana. Una alternativa evalúa los probióticos microencapsulados y su efecto en la salud intestinal. Objetivo: Determinar Lactobacillus plantarum microencapsulado sobre parámetros intestinales e inmunológicos pollos engorde. Materiales métodos: A 240 Ross-308-AP un día nacidos se suministró alimento con o sin adición probiótico bajo siguiente modelo:...