Reed Harder

ORCID: 0000-0001-9281-8974
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About
Contact & Profiles
Research Areas
  • Hate Speech and Cyberbullying Detection
  • Aviation Industry Analysis and Trends
  • Wikis in Education and Collaboration
  • Genetic and phenotypic traits in livestock
  • Pancreatic and Hepatic Oncology Research
  • Social Media and Politics
  • Genetic Associations and Epidemiology
  • Cancer Genomics and Diagnostics
  • Facility Location and Emergency Management
  • Clinical Laboratory Practices and Quality Control
  • High Temperature Alloys and Creep
  • Multidisciplinary Warburg-centric Studies
  • Healthcare Operations and Scheduling Optimization
  • Microstructure and Mechanical Properties of Steels
  • Optimization and Search Problems
  • Crime Patterns and Interventions
  • Air Traffic Management and Optimization
  • Consumer Market Behavior and Pricing
  • Antioxidant Activity and Oxidative Stress
  • Misinformation and Its Impacts
  • Game Theory and Applications
  • Cancer-related Molecular Pathways
  • Genetic Mapping and Diversity in Plants and Animals
  • Computational and Text Analysis Methods
  • Nutrition, Genetics, and Disease

Dartmouth College
2014-2019

Dartmouth Hospital
2016-2017

Universitätsklinikum Knappschaftskrankenhaus Bochum
1994

Significance Theory predicts that chronic pathogens with vertical or familial transmission should become less virulent over time because of coevolution. Although transmitted in this way, Helicobacter pylori is the major causative agent gastric cancer. In two distinct Colombian populations similar levels H. infection but different incidences cancer, we examined human and pathogen ancestry matched samples to assess whether their genomic variation affects severity premalignant lesions....

10.1073/pnas.1318093111 article EN Proceedings of the National Academy of Sciences 2014-01-13

Legal reasoning requires identification through search of authoritative legal texts (such as statutes, constitutions, or prior judicial opinions) that apply to a given question. In this paper, using network representation US Supreme Court opinions integrates citation connectivity and topical similarity, we model the activity law an organizing principle in evolution corpus texts. The (parametrized) probabilistic behavior generates Pagerank-style ranking turn gives rise natural geometry...

10.1007/s10506-018-9224-2 article EN cc-by Artificial Intelligence and Law 2018-03-09

10.1016/j.tre.2017.03.005 article EN Transportation Research Part E Logistics and Transportation Review 2017-03-27

Background. In response to demand for fast and efficient clinical testing, the use of point-of-care testing (POCT) has become increasingly common in United States. However, studies POCT implementation have found that adopting may not always be advantageous relative centralized laboratory testing. Methods. We construct a simulation model patient flow an outpatient care setting evaluate tradeoffs involved across multiple dimensions, comparing measures outcomes varying scenarios, regimes,...

10.1177/2381468319856306 article EN cc-by-nc MDM Policy & Practice 2019-01-01

Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity. PAI-1 highly heritable, but few genes associated with it explain only small portion its variation. Studies typically employ linear regression to estimate effects genetic variants on levels, not normally distributed, even after transformation. Therefore, alternative statistical methods may provide greater power identify...

10.1371/journal.pone.0136379 article EN cc-by PLoS ONE 2015-08-31

Genetic studies of human diseases have identified many variants associated with pathogenesis and severity. However, most used only statistical association to assess putative relationships disease, ignored other factors for evaluation. For example, evolution is a factor that has shaped disease risk, changing allele frequencies as populations migrated into inhabited new environments. Since common differ among in frequency, does prevalence, we hypothesized patterns population structure, taken...

10.1186/s13040-016-0091-7 article EN cc-by BioData Mining 2016-04-02

Airlines make capacity and fare decisions in a competitive environment. Capacity decisions, encompassing about frequency of service seats-per-flight, affect both the operating costs revenues airlines. These have significant implications for performance air transportation system as whole. different airlines are interdependent, serving tools an arsenal. This interdependency motivates game theoretic approach to modeling decision process. (especially frequency) typically made months advance...

10.1145/3040230.3040235 article EN ACM SIGMETRICS Performance Evaluation Review 2017-01-12

In this paper we present Version 1.0 of an implementation a Wiki reference parser with light-weight plugin in the form Google Chrome Extension Javascript. The output is "verification score" for any Wikipedia page, constructed from combination scores derived accessibility and quality. extension presented herein works pre-stored database DOI checks. Future versions working real-time are also discussed. This work suggests generalizations to verification checkers arbitrary webpages possibly even...

10.1145/3041021.3053364 article EN 2017-01-01

10.1016/j.tre.2019.05.003 article EN Transportation Research Part E Logistics and Transportation Review 2019-05-13

Legal reasoning requires identification, through search, of authoritative legal texts (such as statutes, constitutions, or prior judicial decisions) that apply to a given question. In this paper we model the concept law search an organizing principle in evolution corpus texts, U.S. Supreme Court opinions. We examine underlying navigable geometric and topological structure opinion (the "opinion landscape") quantify study its dynamic evolution. realize document network which nodes are...

10.2139/ssrn.2740136 article EN SSRN Electronic Journal 2016-01-01

The verifiability of online information is important, but difficult to assess systematically. We examine in the case Wikipedia, one world's largest and most consulted sources. extend prior work about quality Wikipedia articles, knowledge production, sources consider references. propose a multidimensional measure that takes into account technical accuracy practical accessibility calculate article scores for sample 5,000 articles 295,800 citations, compare differently weighted models...

10.48550/arxiv.1509.05631 preprint EN other-oa arXiv (Cornell University) 2015-01-01

Distribution of recombination hotspots surrounding ET SNP rs12615624, idenitifed by comparing CEU-TSI (high Fst; 95th percentile), CEU-CHB percentile) and TSICHB (low 5th percentile). (PDF 15 kb)

10.5072/fk2.stagefigshare.c.2715074_d9.v1 article EN 2016-01-01
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