A5064255411- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Veterinary medicine and infectious diseases
- Galectins and Cancer Biology
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Microbial Metabolites in Food Biotechnology
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Whipple's Disease and Interleukins
- Hepatitis C virus research
- Photodynamic Therapy Research Studies
- Probiotics and Fermented Foods
Thammasat University
2012-2025
Thammasat University Hospital
2015-2024
Airlangga University
2021-2024
Thailand Science Research and Innovation
2023
Chulabhorn Hospital
2021
Hodges University
2021
Bangkok Hospital
2013-2019
Pathumthani University
2018-2019
Chulalongkorn University
1999-2016
Rajavithi Hospital
2013-2016
Abstract Background and Aim: Gastric cancer is a major health burden in the Asia–Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate for preventing gastric cancer. Methods: A multidisciplinary group developed statements using Delphi approach. Relevant data were presented, quality of evidence, strength recommendation, level graded. Results: Helicobacter pylori infection necessary not sufficient causal factor non‐cardia adenocarcinoma. high...
Innate immunity plays important roles in the primary defense against pathogens, and epidemiological studies have suggested a role for Toll-like receptor 1 (TLR1) Helicobacter pylori susceptibility. Microarray analysis of gastric biopsy specimens from H. pylori–positive uninfected subjects showed that TLR10 messenger RNA (mRNA) levels were upregulated approximately 15-fold infected subjects; these findings confirmed by real-time quantitative polymerase chain reaction analysis....
Environmental factors such as food, lifestyle and prevalence of Helicobacter pylori infection are widely different in Asian countries compared with the West, physiological functions genetic Asians may also be from those Westerners. Establishing an consensus for functional dyspepsia is crucial order to attract attention data countries, articulate experience views experts, provide a relevant guide on management primary care physicians working Asia.Consensus team members were selected experts...
Background: Helicobacter pylori (H. pylori) infection is important risk factors for chronic gastritis, peptic ulcer andgastric cancer. Bismuth-containing quadruple therapy has recently been the first-line regimen recommended in manyEuropean countries but limited efficacy ASEAN especially Thailand. This study was aim to evaluate ofhigh dose PPI with probiotics supplement H. eradication. Methods:In this double-blind randomized placebo-controlled study, infected patients were receive 7-or14-day...
Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response decrease motor fluctuations.
Abstract Background Physical frailty is related with morbidity and mortality in patients cirrhosis. Currently, there no approved treatment of these patients. Here, we evaluated the efficacy 16 weeks branched-chain amino acids (BCAA) supplementation on frail compensated cirrhotic Methods After a 4-week run-in period consisted dietary exercise counseling, frailty, defined by liver index (LFI)≥4.5, were randomly assigned (1:1) to BCAA or control group. The group received twice daily BCAAs (210...
ABSTRACT The vacuolating cytotoxin gene of Helicobacter pylori , vacA induces cytoplasmic vacuolation in gastric epithelial cells. Recently, the intermediate (i) region, which is located between signal (s) and middle (m) regions, was identified as a third polymorphic determinant activity. In there are approximately 81-bp deletions i m regions (denoted d region). aim to clarify roles region relation H. -related diseases histopathological mucosal changes. We assessed s-, m-, i-, d-region...
AIM:To revealed the prevalence of Helicobacter pylori (H.pylori ) infection in Bhutanese population. METHODS:We recruited a total 372 volunteers (214 females and 158 males; mean age 39.6 ± 14.9 years) from three cities (Thimphu, Punaka, Wangdue).The status H. was determined based on five different tests: rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), serum anti -antibody. RESULTS:The serological showed significantly higher positive rate compared with CLO test,...
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers in men and third cancer woman Thailand. This retrospective study was designed to assess prevalence, clinical manifestations, treatment outcomes prognosis HCC central region Materials Methods: The authors retrospectively reviewed all patients aged more than 15 years old Thammasat university hospital (TUH) during period from January 2007 December 2012. Clinical information, biochemical tests radiologic findings were...
Abstract Potassium-competitive acid blockers (P-CABs) provide potent inhibition, yet studies on P-CAB-based quadruple therapy for H. pylori eradication are limited. We theorized that integrating bismuth subsalicylate into a regimen could enhance rates. However, data the efficacy of vonoprazan notably scarce. Therefore, aim this study was to evaluate vonoprazan-based in areas with high clarithromycin and levofloxacin resistance. This prospective, single-center, randomized trial conducted...
ABSTRACT Background. Thailand is at the cultural cross roads between East and South Asia. It has been suggested that this also region where predominant Helicobacter pylori (H. pylori) genotype changes from Asian to Asian. Methods. We compared molecular epidemiology outcome of H. infections among different ethnic groups in (Thai, Thai-Chinese Chinese). isolates were genotyped by polymerase chain reaction based on cagA, cag right end junction vacA genotypes. Results. Ninety-eight 38 Thai, 20...
Helicobacter pylori (H. pylori) remains an important cause of gastric cancer and peptic ulcer disease worldwide. Treatment H. infection is one the effective ways to prevent cancer. However, standard triple therapy for eradication no longer in many countries, including Thailand. This study was designed evaluate efficacy adding bismuth probiotic eradication.In this prospective single center study, infected gastritis patients were randomized receive 7- or 14-day plus with placebo. regimen...
Background: Helicobacter pylori (H. pylori) infection is currently considered as an infectious disease irrespective ofsymptoms and stage of disease. This study aimed to survey the impact H. current managementapproaches in Southeast Asian countries. Materials methods: a among 26 experts from 9 SoutheastAsian countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand Vietnam),who attended meeting develop ASEAN consensus on management November 2015. Results:...
Background Helicobacter pylori treatment failure remains a challenging problem. This study aimed to identify predictive factors for successful eradication in patients following failures. Methods was retrospective cohort study. included 1,050 dyspeptic diagnosed with H . infection at tertiary care center Thailand between March 2014 and October 2021. Patients’ demographic data, endoscopic findings, culture, antimicrobial susceptibility testing (AST), regimens outcomes were analysed. Results Of...
Abstract Helicobacter pylori disturbs the stomach lining during long-term colonization of its human host, with sequelae including ulcers and gastric cancer 1,2 . Numerous H. virulence factors have been identified, showing extensive geographic variation 1 Here we identify a ‘Hardy’ ecospecies that shares ancestry ‘Ubiquitous’ from same region in most genome but has nearly fixed single-nucleotide polymorphism differences 100 genes, many which encode outer membrane proteins host interaction...
Abstract Background and Aim: Eradication rate for Helicobacter pylori infection with standard triple therapy has globally declined including in Thailand, new regimens are required that provide reliable high eradication rates. The study was designed to determine whether concomitant administered either 5 or 10 days would produce a ≥ 95% (grade A) treatment success H. infected Thai subjects nonulcer dyspepsia. Methods: Two prospective, but separate, pilot single‐center studies were carried out...
The present study was designed to determine the eradication rate of 10 day sequential therapy in genotypic clarithromycin-resistant Helicobacter pylori group identified by molecular polymerase chain reaction (PCR) detection Thai patients.Between May 2007 and June 2010, patients who had undergone gastroscopic examination at King Chulalongkorn Memorial Hospital, for dyspeptic symptoms were recruited. Two biopsy samples from gastric antrum obtained, one rapid urease test another PCR....
Objective Standard triple therapy for H elicobacter pylori eradication is no longer effective as an empiric choice in most areas. Even low clarithromycin resistance areas, results ≥95% are infrequently achieved. This study was designed to search a version of standard use prevalence areas or tailored that highly irrespective CYP 2C19 genotype. Design Two prospective pilot single center studies were performed Thailand. H. ‐infected subjects randomized 7‐ 14‐day regimens using high‐dose proton...
Background Gastric intestinal metaplasia (IM) can lead to gastric cancer. Until now, there have been limited studies of predictors for regression and progression IM. This study aimed determine risk factors associated with or IM guiding proper management prevention Methods 2,025 patients undergoing gastroscopy in Thammasat University Hospital, Thailand were enrolled during September 2017-August 2019. Patients’ data including baseline characteristics, laboratory results, histopathology...