A5079701697- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Research on Leishmaniasis Studies
- Liver Disease and Transplantation
- Parasite Biology and Host Interactions
- Cardiac Valve Diseases and Treatments
- Antimicrobial Resistance in Staphylococcus
- Hepatocellular Carcinoma Treatment and Prognosis
- Trypanosoma species research and implications
- Hepatitis B Virus Studies
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Parasitic infections in humans and animals
- Diet and metabolism studies
- Amoebic Infections and Treatments
- Cardiac pacing and defibrillation studies
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
- Inflammatory Bowel Disease
- Helminth infection and control
Universidade Federal de Minas Gerais
2016-2025
Hospital das Clínicas da Universidade Federal de Minas Gerais
2009-2023
Division of Undergraduate Education
2022
Pathological Society
2022
University of Chile
2022
Fundação Faculdade de Medicina
2016
Faculdade de Ciências Médicas de Minas Gerais
2016
Universitätsklinikum Gießen und Marburg
2001
Nonalcoholic fatty liver disease is the most prevalent chronic in Western countries; it can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocarcinoma. The importance of gut-liver-adipose tissue axis has become evident treatments targeting gut microbiota may improve inflammatory metabolic parameters NASH patients. In a randomized, controlled clinical trial, involving 50 biopsy-proven patients, we investigated effects synbiotic supplementation on parameters, hepatic...
Cytokines are involved in the immunopathogenesis of nonalcoholic fatty liver disease (NAFLD), but relationship between them and clinical parameters NAFLD progression is still unknown. Using flow cytometry, we evaluated plasma levels IL-1β, IL-6, IL-12, TNF IL-10 their association with biochemical function during simple steatosis (NAFL) steatohepatitis (NASH) biopsy-proven patients. The NASH patients showed higher IL-6 associated a lower IL-10/IL-6 ratio. Besides heatmaps were similar NAFL...
Summary Considering the complexity of immunological events triggered during active visceral Leishmaniasis (VL), relevance segregation immune response human VL into type 1 and 2 still remains unclear. For this purpose, in individuals living risk areas for VL, we have evaluated especially asymptomatic patients with plasmatic levels cytokines reactive nitrogen species under ex vivo conditions. In addition, also performed an analysis intracellular cytokine patterns circulating leucocytes after...
Background: Although enzyme-linked immunosorbent assay (ELISA) is highly sensitive and specific for the diagnosis of Helicobacter pylori infection in adults, their performance children still controversial. Methods: A second-generation ELISA was used to evaluate IgG response H. serum 130 consecutive who underwent upper gastrointestinal endoscopy. The presence determined antral biopsy specimens by culture, urease test, histologic analysis. Results: Sixty-eight (all 20 had duodenal ulcer) were...
Abstract We investigated the cytokine profile of cells innate immune response and its association with active (ACT), asymptomatic (AS) cured (CUR) human visceral leishmaniasis (VL), as well noninfected (NI) subjects. The frequency cytokine‐producing was determined after short‐term in vitro incubation whole peripheral blood samples soluble Leishmania antigen (SLA). Our data demonstrated a predominant type 2 NI ACT. In NI, we observed an increase IL‐4 + neutrophils, IL‐10 eosinophils besides...
Recent evidence suggests that non-alcoholic fatty liver disease is associated with diet. Our aim was to investigate the dietary patterns of a Brazilian population this condition and compare them recommended diet.A cross-sectional study conducted on 96 patients before any dietetic counseling. All underwent abdominal ultrasound, biochemical tests, evaluations, anthropometric evaluations. Their food intake assessed by semi-quantitative food-frequency questionnaire 24-hour recall.The median...
Cirrhosis has been pointed out as a clinical entity that leads to worse prognosis in COVID-19 patients. However, this concept is controversial the literature. We aimed evaluate outcomes by comparing patients with cirrhosis those without Brazilian cohort. Data from 20,164 inpatients were collected 41 hospitals Brazil between March September 2020 and 2021 August 2022. compared 117 632 matched controls. A propensity score model was used adjust for potential confounding variables, incorporating...
Objetivo: Avaliar a relação entre grau de dependência dos cuidados enfermagem e tempo internação hospitalar prolongado. Métodos: Estudo coorte realizado em um hospital universitário brasileiro no período junho outubro 2018. A amostra do estudo compreendeu pacientes adultos internados unidades clínica médica. Internação com superior mediana foi considerada prolongada. Aplicou-se modelo análise sobrevida risco competitivo para testar associação escore Fugulin Resultados: Participaram 419 (58%)...
We recently evaluated the in vitro proliferative response and interferon (IFN)-γ production of peripheral blood mononuclear cells from a group 25 people who were treated for Chagas' disease during acute phase Trypanosoma cruzi infection followed up period 14–30 years. On basis parasitological serological tests, individuals classified as cured (C), dissociated, or not (NC). Members C (the without cardiac alterations) presented significantly stronger against parasite antigens, with secretion...
To describe the epidemiological, clinical, and laboratory profile of infective endocarditis (IE) at a Brazilian tertiary care center, to identify predictors in-hospital mortality.Data from 62 patients who fulfilled modified Duke's criteria for IE during seven-year period were gathered prospectively. The Cox proportional hazards model was used predictive factors death.The mean age 45 years, 39 (63%) male. median time admission diagnosis 15 days. Rheumatic heart disease predominant underlying...
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects a simple carbohydrate-rich diet on development obesity-related NAFLD impact physical training metabolic abnormalities associated with disorder. Sixty Wistar rats were randomly separated into control groups, which fed sucrose-enriched (18% carbohydrates) standard diet, respectively. At end each period (5, 10, 20, 30...
Infective endocarditis (IE) is a severe disease with high mortality rate. Cytokines participate in its pathogenesis and may contribute to early diagnosis improving the outcome. This study aimed evaluate cytokine profile IE. Serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12 tumor necrosis factor (TNF)-α were measured by cytometric bead array (CBA) at 81 IE patients, compared 34 healthy subjects 30 patients non-IE infections, matched age gender. Mean was 47±17 years (range,...
BackgroundThe early identification of patients at risk complications infective endocarditis (IE) using parameters obtained as part routine practice is essential for guiding clinical decision-making. This study aimed to identify a parameter hospital admission that predicts the outcome, adding value other well-known factors poor prognosis in IE.MethodsTwo hundred and three with IE were included this study. Clinical evaluation, echocardiography, blood cultures, laboratory tests performed...
AbstractActinomycosis is an uncommon entity, caused by anaerobic bacterium, Actinomyces israelii, which a component of the human oral and gastrointestinal flora. The cervicofacial region commonest site disease, abdomen second commonest. In this situation disease almost always unifocal restricted to right colon, especially cecum. We report here case patient with very rare form characterized multiple foci abdominal involvement most severe lesions localized in transverse sigmoid colon. clinical...