A5086040458- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Cell death mechanisms and regulation
- Glioma Diagnosis and Treatment
- Metal complexes synthesis and properties
- Lung Cancer Research Studies
- NF-κB Signaling Pathways
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Circadian rhythm and melatonin
- Cancer Treatment and Pharmacology
- Head and Neck Cancer Studies
- Radiation Dose and Imaging
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
University of Debrecen
2023
Rio Grande Bible Institute
2022
University of Oklahoma Health Sciences Center
2012-2021
OU Health Stephenson Cancer Center
2013-2020
Oklahoma State University Oklahoma City
2013-2020
Oklahoma City University
2011-2017
University of Oklahoma
2008-2017
OU Health
2008-2014
The Maria Sklodowska-Curie National Research Institute of Oncology
2010
The University of Texas Health Science Center at San Antonio
1998-2008
EMT-6 murine mammary tumors were made resistant to cis -diamminedichloroplatinum (II) (CDDP), carboplatin, cyclophosphamide (CTX), or thiotepa in vivo by treatment of tumor-bearing animals with the drug during a 6-month period. In spite high levels resistance, no significant resistance was observed when cells from these exposed drugs vitro. The pharmacokinetics CDDP and CTX altered bearing respective tumors. all tumor lines except for EMT-6/thiotepa decreased 3 6 months passage absence...
Fifty (5%) of 1039 patients with non-Hodgkin's lymphomas registered on two Southwest Oncology Group clinical trials between 1972 and 1977 developed evidence central nervous system (CNS) lymphoma. Thirty-nine (3.7%) had leptomeningeal involvement, 10 (1%) focal cerebral involvement 2 (0.1%) spinal cord compression. Cytologic examination the cerebrospinal fluid (CSF) was most reliable diagnostic technique. Patients diffuse histologies those nodular histiocytic lymphoma highest incidence CNS...
Two double-blind, crossover trials comparing the antiemetic effectiveness of nabilone, a new synthetic cannabinoid, with that prochlorperazine were conducted in patients severe nausea and vomiting associated anticancer chemotherapy. Of 113 evaluated, 90 (80 per cent) responded to nabilone therapy, whereas only 36 (32 (P less than 0.001). Complete relief symptoms was infrequent, occurring nine (8 given nabilone. When both drugs compared, 0.01) episodes 0.001) significantly lower Moreover,...
Durable complete remissions (CRs) can be achieved in patients with diffuse large-cell lymphoma (DLCL) multidrug chemotherapy. The length of time to reach CR may predictive treatment outcome. However, defining by chest radiograph or computed tomography (CT) is often difficult since residual abnormalities do not always indicate disease. We have prospectively evaluated the ability gallium-67 citrate (Ga-67) imaging define disease and predict outcome 37 consecutive DLCL. Patients received 296...
Abstract Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic inhibitors can overcome the limitations of genetic inhibition. In this study, we examined antitumor activity CMLD-2, a small-molecule inhibitor directed against HuR, using non-small cell lung (NSCLC) as model. CMLD-2 efficacy was tested vitro H1299, A549, HCC827,...
// Meghna Mehta 1,* , Kanthesh Basalingappa James N. Griffith 1 Daniel Andrade Anish Babu 2,3 Narsireddy Amreddy Ranganayaki Muralidharan Myriam Gorospe 4 Terence Herman Wei-Qun Ding 2 Rajagopal Ramesh 2,3,5 and Anupama Munshi 1,3 Department of Radiation Oncology, The University Oklahoma Health Sciences Center, City, Oklahoma, USA Pathology, 3 Stephenson Cancer National Institute on Aging, Institutes Health, Baltimore, Maryland, 5 Graduate Program in Biomedical Sciences, * These authors...
Abstract: The objective of this study was to examine the potential radioprotective properties pharmacological doses melatonin in whole‐body irradiated mice. CD2‐FI male mice were treated with melatonin. a secretory product pineal gland, and then an acute dose (150 cGy) 137 Cs gamma rays. Peripheral blood bone marrow cells examined for genetic damage, which determined by comparing incidence micronuclei (MN) both pre‐treated non‐treated animals (and control mice). percentages polychromatic...
The purpose of this study was to evaluate the treatment Merkel cell carcinoma.We reviewed 85 cases carcinoma. There were 68 males and 17 females. majority involved head neck sites (48%), followed by extremities (38%) trunk (14%). Sixty-seven percent patients had stage I disease that localized skin origin at presentation. Twenty-five 8% II (nodal metastasis) III (distant metastasis), respectively. Surgical intervention included local or wide excision +/- nodal dissection (68%), radical...
Curcumin has been shown to exhibit growth inhibitory effects and induce apoptosis in a broad range of tumors. Accordingly, we investigated the radiosensitizing curcumin human neuroblastoma cells. SK-N-MC cells exposed either 2 Gy alone, or pretreated with (100 nM) NFkappaB inhibitor peptide SN50 (50 were harvested after 48 h. Radioresistance was measured using clonogenic MTT assay, DNA-binding activity electrophoretic mobility shift Annexin V-FITC staining. Pathway (apoptosis) specific...
Because the rate of heating alters various cellular events associated with exposure to hyperthermia (including cell death), effect this parameter on cytotoxic interaction between selected anticancer drugs and was studied. The cisplatin, 1,3-bis(2-chloroethyl)-1-nitrosourea, adriamycin at 42.4 degrees C bleomycin methotrexate 43 were tested in Chinese hamster ovary (CHO) cells vitro. Heating times ranged from less than 3 minutes (immediate exposure) hours. For all tested, synergistic...
Five patients were treated with a combination of Adriamycin/cis-platinum/cyclophosphamide for faradvanced and/or recurrent cancers the salivary gland. Adriamycin, 40 mg/m2, and cis-platinum, 50 given on day 1; cyclophosphamide, 200 mg/m2 daily four days, was by mouth third to sixth each monthly therapy course. Two achieved complete remission, lasting five months, three others had partial remissions from one seven months (median six months) in duration. Therapy well tolerated. Severe nausea...
Induced radioresistance in the surviving cancer cells after radiotherapy could be associated with clonal selection leading to tumor regrowth at treatment site. Previously we reported that post-translational modification of IκBα activates NFκB response ionizing radiation (IR) and plays a key role regulating apoptotic signaling. Herein, investigated orchestration IR human neuroblastoma. Both vitro (SH-SY5Y, SK-N-MC, IMR-32) vivo (xenograft) studies showed persistently induced DNA binding...
Determining the driving factors and molecular flow-through that define switch from favorable to aggressive high-risk disease is critical betterment of neuroblastoma cure.In this study, we examined cytogenetic tumorigenic physiognomies distinct population metastatic site- derived cells (MSDACs) tumors, showed influence acquired genetic rearrangements on poor patient outcomes.Karyotyping in SH-SY5Y MSDACs revealed trisomy 1q, with additional non-random chromosomal 1q32, 8p23, 9q34, 15q24,...
Abstract In order to study the mechanisms responsible for resistance CDDP, 5 human tumor cell lines were made resistant CDDP by repeated in vitro exposures. After cloning it was found that developed between 3.3‐fold and 17‐fold more than parental at IC 90 . These also carboplatin tetraplatin; however, tetraplatin lower other platinum complexes. Sensitivity assessed Adria, MTX, 5‐FU, chlorambucil, 4‐HC, 4‐HIF, BCNU, Thiotepa, HN2, Mito C L‐PAM, no consistent cross‐resistance observed. As...