A5056804345- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- COVID-19 and healthcare impacts
- Chemotherapy-induced cardiotoxicity and mitigation
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer survivorship and care
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- COVID-19 Clinical Research Studies
- Economic and Financial Impacts of Cancer
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Ultrasound and Hyperthermia Applications
- Healthcare cost, quality, practices
- Body Contouring and Surgery
- Radiation Dose and Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biomarkers in Disease Mechanisms
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
The Christie NHS Foundation Trust
2019-2024
University of Manchester
2019-2024
Cancer Research UK Manchester Institute
2022-2023
National Health Service
2022-2023
The Christie Hospital
2022
Gloucestershire Hospitals NHS Foundation Trust
2021
Weston Park Cancer Centre
2021
University College Hospital
2021
University College London
2021
Addenbrooke's Hospital
2021
The RTOG 0617 trial presented a worse survival for patients with lung cancer treated in the high-dose (74 Gy) arm. In multivariable models, radiation level and whole-heart volumetric dose parameters were associated survival. this work, we consider heart subregions to explain observed difference between levels.
For patients with lung cancer treated radiation therapy, a dose to the heart is associated excess mortality; however, it often not feasible spare whole heart. Our aim define cardiac substructures and thresholds that optimally reduce early mortality.Fourteen were delineated on 5 template representative anatomies. One thousand one hundred sixty-one non-small cell registered nonrigidly these anatomies, their therapy doses mapped. Mean maximum each substructure extracted, means evaluated as...
<h2>Abstract</h2><h3>Introduction</h3> Heart dose has emerged as an independent predictor of overall survival in patients with NSCLC treated radiotherapy. Several studies have identified the base heart a region enhanced sensitivity and potential target for cardiac sparing. We present dosimetric analysis multicenter, randomized PET-Plan trial (NCT00697333) first time include left ventricular ejection fraction (EF) at baseline metric function. <h3>Methods</h3> A total 205 inoperable stage II...
Abstract Introduction Prehabilitation improves both physiological measurements and clinical outcomes for patients undergoing surgery lung cancer. The feasibility, acceptability efficacy of prehabilitation having curative-intent radiotherapy cancer is uncertain. Methods Prehab4Cancer (P4C) a regional, community-based service with in Greater Manchester the United Kingdom. We present an evaluation P4C over 2-year period. Feasibility was evaluated against prespecified key performance indicators....
For lung cancer patients treated with radiotherapy, radiation dose to the heart has been associated overall survival, volumetric statistics widely presented. However, critical cardiac structures are present on hearts surface, where this approach may be sub-optimal. In work we a methodology for creating surface maps and identify regions excess is in worse survival.A modified cylindrical coordinate system was implemented map patients. Validation performed by mapping chambers 55 patients,...
Cancer patients are at increased risk of death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). and its treatment affect many haematological biochemical parameters, therefore we analysed these prior to during disease 2019 (COVID-19) correlated them with outcome.
Patients with cancer are at increased risk of severe COVID-19 disease, but have heterogeneous presentations and outcomes. Decision-making tools for hospital admission, severity prediction, monitoring early intervention critical. We sought to identify features disease in patients predicting build a decision support online tool, Risk Oncology Evaluation Tool (CORONET).
Pragmatic methodologies, often termed rapid-learning, are being pursued that can match the pace of innovation in radiotherapy and generate evidence from real-world treatment setting. It is important to understand feasibility implementing such pragmatic approaches before their application practice. This study investigated key professional stakeholders' perceptions opinions rapid-learning data (RWD). Twenty-three interviews were conducted with stakeholders based across five UK cancer centres....
Stereotactic radiosurgery (SRS) for brain metastases has been carried out at the Leeds Gamma Knife Centre since March 2009. The aim of this study was to examine outcomes and toxicity in our initial cohort patients. medical records patients with referred between 2009 July 2010 were retrospectively reviewed. Data on survival, primary tumour, Karnofsky performance status, time from diagnosis identification metastases, previous treatment results staging prior SRS recorded. Patients followed up...
There is increasing evidence of cardiac toxicity thoracic radiotherapy however, it difficult to draw conclusions on dose constraints due the heterogeneity published studies. Moreover, few studies record data cause death. The aim this paper investigate relationship between conventional dosimetric parameters and death with causes using from UK national registry.Data cancer diagnosis, treatment following radical lung were obtained Public Health England for all patients treated at Christie NHS...
Lung cancer survival remains poor. The introduction of Intensity-Modulated Radiotherapy (IMRT) allows treatment more complex tumours as it improves conformity around the tumour and greater normal tissue sparing. However, there is limited evidence assessing clinical impact IMRT. In this study, we evaluated whether IMRT had an influence on proportion patients treated with curative-intent radiotherapy over time, effect patient survival.Patients thoracic at our institute between 2005 2020 were...
Minimising heart exposure during lung radiotherapy (RT) is important due to association between increased cardiac dose and adverse outcomes such as toxicity reduced overall survival. This study evaluated the impact of incorporating a avoidance area (CAA) located at base on received by subregions thoracic organs risk.
AimsIn response to the COVID-19 pandemic, guidelines on reduced fractionation for patients treated with curative-intent radiotherapy were published, aimed at reducing number of hospital attendances and potential exposure vulnerable minimise risk infection. We describe changes that took place in management stage I–III lung cancer from April October 2020.Materials methodsLung Radiotherapy during Pandemic (COVID-RT Lung) is a prospective multicentre UK cohort study. The inclusion criteria were:...
Abstract Objectives We validated an auto-contouring algorithm for heart substructures in lung cancer patients, aiming to establish its accuracy and reliability radiotherapy (RT) planning. focus on contouring amalgamated set of subregions the base considered be a new organ at risk, cardiac avoidance area (CAA), enable maximum dose limit implementation RT Methods The study validates deep-learning model specifically adapted CAA (which includes right atrium, aortic valve root, proximal segments...