A5050675882- Toxic Organic Pollutants Impact
- Cardiac, Anesthesia and Surgical Outcomes
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Cancer survivorship and care
- Airway Management and Intubation Techniques
- Immunotoxicology and immune responses
- Pharmacogenetics and Drug Metabolism
- Hemodynamic Monitoring and Therapy
- Tracheal and airway disorders
- Animal testing and alternatives
- Hip and Femur Fractures
- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
- Delphi Technique in Research
- Congenital Heart Disease Studies
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cardiac Arrest and Resuscitation
- Birth, Development, and Health
- Frailty in Older Adults
- Weed Control and Herbicide Applications
- Environmental Toxicology and Ecotoxicology
University of Manchester
2007-2025
Manchester University NHS Foundation Trust
2015-2025
Wythenshawe Hospital
2024-2025
Manchester Royal Infirmary
2011-2024
Royal Alexandra Hospital
2024
Manchester Metropolitan University
2020-2023
University of South Alabama
2022
Manchester University
2022
London Cancer
2022
University of California, San Francisco
2017
Aberrant or defective immune responses are known to be the result of primary immunodeficiency diseases, e.g., in DiGeorge syndrome (thymic hypoplasia) man, homozygous mice with mut...
Treatment of female F-344 rats and C57B1/6 mice with 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) during the latter half gestation in postnatal period resulted a severe depletion lymphocytes thymic cortex offspring. Cellular immunity was impaired these animals. Allograft rejection times were prolonged mice. Graft-versus-host (GVH) activity spleen cells as well response rat thymus to phytohemagglutinin (PHA) reduced on cell-for-cell basis. No reduction occurred concanavalin A...
Catheter-related thrombosis is a relatively common complication of central venous catheter insertion. Central use ubiquitous in the critical care setting and often patients with multiple risk factors for thromboembolism. With trend towards increased peripherally inserted catheters, incidence catheter-related likely to increase further. Despite scale problem, there paucity evidence-based guidelines concerning management thrombosis, particularly critically unwell patients. This has led...
The effects of TCDD exposure on the developing immune system were investigated in F344 rats. Fetal and neonatal rats exposed to through maternal dosing (5 μg/kg) day 18 gestation days 0, 7, 14 postnatal life (group I). Another group was only II). Body weights thymus/body weight ratios found be suppressed up 145 age I, but 39 II. Parameters cell‐mediated humoral function investigated. without affecting function. Suppression T‐cell selective that “helper” cell not suppressed.
The effects of subclinical levels 2,3,7,8-tetrachloridibenzo-p-dioxin (TCDD) on the response mice to infection with either Salmonella bern or Herpesvirus suis, also known as pseudorabies virus, are reported. TCDD is a contaminant certain commercially useful chemicals, such chlorinated phenols herbicides. It has been shown cause thymic atrophy and suppress cell-mediated immunity in laboratory animals. Sublethal were used: 0.5, 1,5, 10, 20 mug/kg, given through gastric tube once weekly for 4...