A5024588356- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Marine Sponges and Natural Products
- Neonatal Health and Biochemistry
- Anesthesia and Neurotoxicity Research
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Crystallization and Solubility Studies
- Immune Response and Inflammation
- X-ray Diffraction in Crystallography
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Prenatal Substance Exposure Effects
- Chemokine receptors and signaling
- Nerve injury and regeneration
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Seaweed-derived Bioactive Compounds
- Inflammatory mediators and NSAID effects
- Neuroscience of respiration and sleep
- Gestational Diabetes Research and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Antimicrobial Peptides and Activities
I-Shou University
2015-2024
E-Da Hospital
2014-2024
Pingtung Christian Hospital
2023-2024
Kaohsiung Medical University
2008-2019
China Medical University
2011-2016
China Medical University Hospital
2016
National Sun Yat-sen University
2010-2014
Kaohsiung Medical University Chung-Ho Memorial Hospital
2008-2013
Kaohsiung Municipal Ta-Tung Hospital
2013
Changhua Christian Hospital
2012
A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) midbrain is characteristic Parkinson's disease. Inflammation brain has long been speculated to play a role pathogenesis this neurological disorder. Recently, we reported that treatment primary rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (LPS) led activation microglia, resident immune cells brain, and subsequent death dopaminergic neurons. The LPS-induced was significantly attenuated by...
Background: Multiple packed red blood cell (PRBC) transfusions in very low birth weight (VLBW) prematurity have been suggested to be a risk factor for the development of retinopathy (ROP) or chronic lung disease (CLD).The purpose this study was examine effect PRBC on outcome VLBW prematurity.Methods: In total, between July 2005 and June 2006, 36 preterm babies were admitted our neonatal intensive care unit randomly allocated "restrictive" (n = 19) "liberal" 17) criteria transfusion.Complete...
Parkinson's disease (PD) is a neurodegenerative that characterized by the progressive loss of dopaminergic (DA) neurons in substantia nigra. However, current treatments for PD are mainly palliative. Recently, researchers discovered neurotoxins can induce Parkinsonian-like symptoms zebrafish. No study to date has investigated characteristics PD, such as neuroinflammation factors, oxidative stress, or ubiquitin dysfunction, this model. Therefore, was aimed at utilizing commonly used clinical...
Abstract Background Exposure to environmental endocrine‐disrupting chemicals ( EDC s) is associated with allergy, chronic inflammation, and immunodeficiency. Phthalates, the common s used in plastic industry, may act as adjuvants disrupt immune system enhance allergy. Plasmacytoid DC pDC are predominant cells secreting type I interferon IFN ) against infection professional antigen‐presenting regulating adaptive immunity. However, effects of phthalates on function unknown. Methods Circulating...
Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are abundant source of growth factors, such as platelet-derived factor (PDGF), transforming β (TGF-β), insulin-like 1 (IGF-1), epithelial (EGF). The complex mechanisms underlying spinal cord injury (SCI) diminish intrinsic repair neuronal regeneration. Several studies...
Postnatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, is associated with allergy development in childhood, suggesting that DEHP may dysregulate immune response infants. We investigated whether newborns through medical treatment affected the gut microbiota pattern and vaccine response, which are both related development. In this prospective cohort study from May 1, 2016 July 31, 2017, respiratory distress who were given intravenous infusions (IVs) enrolled as group,...
<h3>Objective:</h3> The purpose of this study was to evaluate the safety and efficacy hydroxyurea (HU) in spinal muscular atrophy (SMA) a randomized, double-blind, placebo-controlled trial. <h3>Methods:</h3> Twenty-eight patients with type 2 SMA 29 3 were randomly assigned (2:1) receive HU or matching placebo for 18 months. initiated at 10 mg/kg/day an 8-week titration 20 mg/kg/day. Subjects assessed baseline (T0) monthly first months (T1–T2) then every throughout treatment (T3–T10)...
In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. the present study, we isolated a natural diterpene product, excavatolide B, cultured Formosan gorgonian Briareum excavatum investigated its anti-inflammatory We found B significantly inhibited mRNA expression of proinflammatory mediators, inducible nitric oxide synthase (iNOS)...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and gait impairment. In previous study, we found that the marine-derived compound 11-dehydrosinulariolide (11-de) upregulates Akt/PI3K pathway to protect cells against 6-hydroxydopamine (6-OHDA)-mediated damage. present SH-SY5Y, zebrafish rats were used examine therapeutic effect of 11-de. The results revealed mechanism which 11-de exerts its effect: increases cytosolic or mitochondrial...
Abstract Osteosarcoma (OSA) is the most common type of cancer that originates in bone and usually occurs young children. OSA patients were treated with neoadjuvant chemotherapy surgery, results disappointing. Marine antimicrobial peptides (AMPs) have been focus antibiotic research because they are resistant to pathogen infection. Piscidin-1 an AMP from hybrid striped bass ( Morone saxatilis × M. chrysops ) has approximately 22 amino acids. Research shown piscidin-1 can inhibit bacterial...
The dopaminergic system in the limbic system, particularly D1/D5 receptor (D1/D5r), is important for certain forms of learning and memory, such as reinforcement learning, well acute development behavioral sensitization to psychostimulants cocaine methamphetamine. Here, whole-cell patch-clamp recordings evoked excitatory postsynaptic currents (EPSCs) mediated by ionotropic glutamate receptors were made from pyramidal neurons CA1 area rat hippocampal slices. Activation D1/D5r a selective...
Exposure to environmental endocrine-disrupting chemicals (EDCs) is often associated with dysregulated immune homeostasis, but the mechanisms of action remain unclear.The aim this study was test a hypothesis that EDCs regulate functions human dendritic cells, front-line, immunoregulatory cell type in contact environment.We investigated circulating myeloid cells (mDCs) from five subjects and measured their responses, or without coculture autologous T two common EDCs, nonylphenol (NP)...