A5020995749- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Neuropeptides and Animal Physiology
- Hepatitis C virus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Restless Legs Syndrome Research
- Palliative Care and End-of-Life Issues
- Hepatitis B Virus Studies
- Vasculitis and related conditions
- Grief, Bereavement, and Mental Health
- Liver Disease Diagnosis and Treatment
- Medical Research and Treatments
- Neuroscience of respiration and sleep
- Metabolomics and Mass Spectrometry Studies
- Anesthesia and Neurotoxicity Research
- Respiratory viral infections research
- Cancer-related cognitive impairment studies
- Gastrointestinal disorders and treatments
- Neuroscience and Neuropharmacology Research
- Complement system in diseases
- Platelet Disorders and Treatments
- Neonatal Respiratory Health Research
- Renal Diseases and Glomerulopathies
- Parkinson's Disease Mechanisms and Treatments
Harbin Medical University
2010-2025
Second Affiliated Hospital of Harbin Medical University
2025
National Beef Cattle Industrial Technology System
2025
Minzu University of China
2025
Beijing Children’s Hospital
2020-2024
Capital Medical University
2020-2024
West China Hospital of Sichuan University
2013-2023
Sichuan University
2013-2023
Jiangsu Province Hospital
2020-2023
Nanjing Medical University
2020-2023
B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results anergy. The vivo role was evaluated with B7-deficient mice. These mice had 70 percent decrease costimulation the response to alloantigen. Despite lacking expression, activated B cells from these bound CTLA-4 GL1 monoclonal antibody, demonstrating that alternative ligand or ligands exist. receptors are functionally important because residual...
Degeneration of dopaminergicrgic neurons in the substantia nigra brain is a hallmark Parkinson's disease and inflammation oxidative stress are closely associated with pathogenesis degenerative neurological disorders. Treatment rat mesencephalic mixed neuron-glia cultures lipopolysaccharide (LPS)-activated microglia, resident immune cells brain, to release proinflammatory neurotoxic factors tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, superoxide subsequently caused damage...
A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) midbrain is characteristic Parkinson's disease. Inflammation brain has long been speculated to play a role pathogenesis this neurological disorder. Recently, we reported that treatment primary rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (LPS) led activation microglia, resident immune cells brain, and subsequent death dopaminergic neurons. The LPS-induced was significantly attenuated by...
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low energy deposition, severe damage surrounding normal cells, and high tumor resistance radiation. Among various radiotherapy methods, boron neutron capture (BNCT) emerged as principal approach improve the therapeutic ratio of malignancies reduce lethality tissue, but it remains deficient in...
Abstract Backgroud Leptomeningeal metastases (LMs) are serious complications of non-small cell lung cancer (NSCLC). This study aimed to investigate the safety and efficacy intrathecal immune checkpoint inhibitors (ICIs) in treating NSCLC-LM. Methods We conducted this prospective phase 1 (ChiCTR2200062245) using a traditional "3 + 3" design with sintilimab (dose escalation 10mg, 20mg, 30mg, 40mg) for NSCLC-LM patients who had progressed from targeted therapy pemetrexed. The primary endpoints...
Escherichia coli is a major pathogen responsible for calf diarrhea. However, it has developed resistance to many antimicrobial drugs their inappropriate usage. The bacterial quorum sensing system transmits information between bacteria, it's important in regulating virulence, drug and acid so on. This can found Gram-negative bacteria operates through acyl-homoserine lactone (AHL) signaling molecules. In this study, type I AHL, N-Octanoyl-L-Homoserine (C8), was added E. growth medium...
Objective While individuals with insomnia consistently complain of cognitive impairment, previous studies on the effect objective measures function have obtained ambiguous results. The relationship between daytime sleepiness and manifestations in patients is not clear. Methods Thirty-six primary (PIPs) 26 good sleep controls (GSCs) age gender matched manner were included study. Participants underwent an overnight polysomnography followed by a multiple latency test (MSLT) examination...
We identified the primary symptoms leading to Chinese patients presenting at hospital with suspected obstructive sleep apnea (OSA) and studied prevalence characteristics of OSA in confirmed cases.We collected data on 350 consecutive (302 males 43±11 years old) who underwent overnight polysomnography (PSG).Among all patients, rankings that led for PSG were observed (33%), snoring alone (29%), choking/gasping (13%), daytime sleepiness (5%) other (20%). For severe OSA, rate was 61%, hypopnea...
Viral pneumonia in children is common and has grave consequences. The study aims to better understand the pathophysiological processes involved onset progression of viral identify effects or biomarkers across different viruses.This collected urine samples from 96 patients with including respiratory syncytial virus (RSV) (n=30), influenza (IV) (n=23), parainfluenza (PIV) (n=24), adenovirus (ADV) (n=19), 31 age- sex-matched normal control (NC) subjects. were analyzed using liquid...
Abstract Mycoplasma pneumoniae is a significant contributor to lower respiratory infections in children. However, the lipidomics and metabolics bases of childhood M. remain unclear. In this study, metabolomics analyses were conducted using UHPLC‐LTQ‐Orbitrap XL mass spectrometry gas chromatography‐triple quadrupole on plasma ( n = 65) urine samples. MS‐DIAL software, combination with LipidBlast Fiehn BinBase DB, identified 163 lipids 104 metabolites samples, as well 208 Perturbed lipid...
Abdominal-type Henoch-Schonlein purpura (HSP) is a common refractory disease in children. Currently, no specific diagnostic biomarker available for HSP.Children with abdominal type HSP were first diagnosed three syndromes using Chinese traditional medicine. The urinary proteomes among the of patients and healthy controls compared two label-free proteomics quantifications, including data-dependent acquisition data-independent acquisition.For comparison between children, total 75 differential...