A5005286005- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Nitric Oxide and Endothelin Effects
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Ion Channels and Receptors
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Cardiac electrophysiology and arrhythmias
- Galectins and Cancer Biology
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Plant-based Medicinal Research
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Neurobiology and Insect Physiology Research
- Phosphodiesterase function and regulation
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2010-2024
National Sun Yat-sen University
2024
National Cheng Kung University
2021
National University of Kaohsiung
2018
George Mason University
2014-2016
United States Department of Agriculture
2013-2015
Agricultural Research Service
2013-2015
University of Maryland, College Park
2011-2013
National Institute of Environmental Health Sciences
2010
Increasing evidence suggests systemic inflammation-caused skeletal muscle atrophy as a major clinical feature of cachexia. Triptolide obtained from Tripterygium wilfordii Hook F possesses potent anti-inflammatory and immunosuppressive effects. The present study aims to evaluate the protective effects molecular mechanisms triptolide on inflammation-induced atrophy.The were investigated in LPS-treated C2C12 myotubes C57BL/6 mice. Protein expressions mRNA levels analysed by western blot qPCR,...
Inflammation and oxidative stress play important roles in the pathogenesis of neurodegenerative disorders such as stroke, traumatic injury, Parkinson disease, Alzheimer disease. Paeonol, a natural compound extracted from Moutan cortex, is potent anti-inflammatory antioxidative agent. The aim this study was to investigate neuroprotective mechanisms paeonol on lipopolysaccharide (LPS)-induced inflammation rat primary microglia 6-hydroxydopamine-induced damage cortical neurons. In LPS-treated...
Ginger has many bioactive compounds with pharmacological activities. However, few studies are known about these activity in chemoresistant cells. The aim of the present study was to investigate anticancer properties ginger phytochemicals docetaxel-resistant human prostate cancer cells vitro. In this study, we isolated 6-gingerol, 10-gingerol, 4-shogaol, 6-shogaol, 10-shogaol, and 6-dehydrogingerdione from ginger. Further, antiproliferation examined (PC3R) sensitive (PC3) cell lines....
Capsaicin, the pungent ingredient in hot pepper, activates and subsequently desensitizes a subset of polymodal nociceptors. Because its initial application to skin produces pain, nonpungent analogs such as olvanil glyceryl nonivamide (GLNVA) were synthesized enhance clinical use. To explore how these differ from capsaicin, whole-cell patch-clamp recordings performed on cultured rat trigeminal ganglion neurons. In neurons held at −60 mV, olvanil, GLNVA found activate one or two kinetically...
In this study, we investigate the anticancer effect of isoobtusilactone A (IOA), a constituent isolated from leaves Cinnamomum kotoense, on human non-small cell lung cancer (NSCLC) A549 cells. IOA was found to induce arrest G2-M phase, apoptosis, increase sub-G1, and inhibit growth these Further investigation revealed that IOA's blockade cycle associated with increased levels p21/WAF1, p27kip1, p53. addition, triggered mitochondrial apoptotic pathway, as indicated by an in Bax/Bcl-2 ratios,...
Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive for Parkinson's disease (PD). PD is neurodegenerative characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The aim this study was to investigate protective mechanisms HBOT on and motor function 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model 1-methyl-4-phenylpyridinium (MPP+)-mediated neurotoxicity SH-SY5Y cells capability. In vivo: male C57BL/6...
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), resulting reduced dopamine levels striatum and eventual onset motor symptoms. Linalool (3,7-dimethyl-1,6-octadien-3-ol) monoterpene aromatic plants exhibiting antioxidant, antidepressant, anti-anxiety properties. The objective this study to evaluate neuroprotective impacts linalool on SH-SY5Y cells, primary mesencephalic cortical...
<b><i>Background and Aims:</i></b> A recent neuroimaging study discovered the neurotoxicity effects of homocysteine (Hcy), which is only seen in elderly women. Estrogens exert a variety actions on brain function that influence cognitive function, mood, neuroprotection. The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related 2 (Nrf2) antioxidant defense pathway has been well-known to afford Here, we first demonstrate roles Nrf2-Keap1...
Exposure to carbon black nanoparticles (CBNPs), a well-known industrial production, promotes pulmonary toxicity through inflammation and oxidative stress. Recent studies show that some polyphenols exert their antioxidant properties regulation of protein kinase C-α (PKC-α) NADPH oxidase (Nox) signaling. Resveratrol, dietary polyphenol in fruits, possesses various health beneficial effects including anti-inflammatory antioxidative properties. In this study, we aimed elucidate the involvement...
Chalcones belong to a class of biologically active polyphenolic natural products. As result their simple chemical nature, they are easily synthesized and show variety promising biological activities. 2-Hydroxy-4′-methoxychalcone (AN07) is synthetic chalcone derivate with potential anti-atherosclerosis effects. In this study, we demonstrated the novel antioxidant, anti-inflammatory, neuroprotective effects AN07. RAW 264.7 macrophages, AN07 attenuated lipopolysaccharide (LPS)-induced...
The presence of preferred orientations in single particle analysis (SPA) by cryo-Electron Microscopy (cryoEM) is currently one the hurdles preventing many structural analyses from yielding high-resolution structures. Although existence mostly related to grid preparation, this technical note, we show that some image processing algorithms used for angular assignment and three-dimensional (3D) reconstruction are more robust than others these detrimental conditions. We exemplify argument with...
AIM: Capsaicin, a pungent ingredient found in red pepper, has long been used spices, food additives, and drugs.Cell death induced by the binding of capsaicin was examined human gastric adenocarcinoma cell line (AGS cells).METHODS: By using XTT-based cytotoxicity assay, flow cytometry TUNEL method, quantitation DNA fragmentation, both fragmentation were detected AGS cells treated with capsaicin.By Western blotting methods, reduced expression Bcl-2, antiapoptotic protein,...
San-Huang-Xie-Xin-Tang (SHXT), composed of Coptidis rhizoma, Scutellariae radix , and Rhei rhizoma is a traditional Chinese medicine used for complementary alternative therapy cardiovascular neurodegenerative diseases via its anti-inflammatory antioxidative effects. The aim this study to investigate the protective effects SHXT in 1–methyl–4–phenylpyridinium (MPP + )/1–methyl–4–phenyl–1,2,3,6–tetrahydropyridine (MPTP) models Parkinson’s disease. Rat primary mesencephalic neurons mouse...