Ischemia/reperfusion (I/R) injury remains a major problem in liver transplantation. I/R causes inflammatory cytokine release, apoptosis, and necrosis. Bone marrow-mesenchymal stem cells (BM-MSCs) can differentiate into hepatocytes vivo, differentiation further increases when are damaged. Exosomes important mediators of cellular connections. Recently, exosomes have been shown to play pivotal role inhibiting hepatocyte apoptosis promoting regeneration. Therefore, we induced MSCs...

Limb ischemia is a refractory disease characterized by persistent inflammation, insufficient angiogenesis, and tissue necrosis. Although mesenchymal stem cells (MSCs) have shown potential for treating limb ischemia, their therapeutic effects are limited low engraftment rates. Therefore, developing an optimal MSC delivery system that enhances cell viability imperative. Selenium, known its cytoprotective properties in various types, offers strategy to enhance effect of MSCs. In this study, we...

This paper investigates the impact of High-Profile Promotions (HPPs), specifically luxury beauty and aroma booths, on environmental sustainability. While most prior research similar pop-up installations has focused their commercial value, this study approaches topic from an sustainability perspective. It quantifies HPPs, transitioning qualitative assessments to quantitative analysis, explores potential protection strategies for brands when planning HPP events, particularly regarding...

A BSTRACT Sodium-glucose co-transporter 2 (SGLT2) inhibitors have convincingly demonstrated efficacy in reducing cardiovascular (CV) and renal complications patients with diabetes mellitus, chronic kidney disease, heart failure. However, their use is also linked to the concern of some adverse events, most common being genital urinary tract infections (UTIs). This review summarizes risks UTIs SGLT2 across large-scale clinical trials, meta-analyses, real-world cohort studies. are shown...

Summary Objective The study aims to evaluate the efficacy of combination therapy with propylthiouracil (PTU) and cholestyramine in treatment Graves’ hyperthyroidism. Background Thyroxine (T4) is metabolized mainly liver by conjugation glucuronides sulphates that enter enterohepatic circulation. Thyrotoxic patients have an abnormal increase thyroid hormone their Previous studies on methimazole for hyperthyroidism shown it be effective adjunctive treatment. In this study, we examined PTU...

Fibroblast growth factor 21 (FGF21) acts as a potent metabolic regulator. Serum FGF21 levels were significantly higher in obesity and type 2 diabetes mellitus (T2DM) populations. The aim of this study was to evaluate the relationship between serum syndrome (MetS) T2DM patients. Fasting blood samples obtained from 126 MetS its components defined according diagnostic criteria International Diabetes Federation. concentrations measured using commercially available enzyme-linked immunosorbent...

Abstract Rosmarinic acid (RA) is an important medicinal metabolite and a potent food antioxidant. We discovered that exposure to high light intensifies the accumulation of RA in leaves perilla (Perilla frutescens (L.) Britt). However, molecular mechanism underlying synthesis response stress remains poorly understood. To address this knowledge gap, we conducted comprehensive analysis employing transcriptomic sequencing, transcriptional activation, genetic transformation techniques. High...

As a new member of the vasculoprotective gasotransmitter family, hydrogen sulfide (H2S) functions similar to nitric oxide (NO) and carbon monoxide (CO). Endothelial cell (EC) death autophagy enable cells cope with progression cardiovascular diseases. However, impacts underlying mechanisms H2S in autophagic process ECs are not completely understood. Here, we investigated effects on human vascular ECs.Human umbilical vein endothelial (HUVECs) were exposed different concentrations (0, 50, 100,...

Perilla (Perilla frutescens), a traditional medicinal and oilseed crop in Asia, contains extremely high levels of polyunsaturated α-linolenic acid (ALA) (up to 60.9%) its seeds. ALA biosynthesis is multistep process catalyzed by fatty desaturases (FADs), but the FAD gene family perilla has not been systematically characterized. Here, we identified 42 PfFADs genome classified them into five subfamilies. Subfamily members had similar exon/intron structures, conserved domain sequences,...

The perilla anthocyanins have important medicinal and ornamental value, their contents are significantly affected by light intensity. In view of molecular mechanisms were not well understood, we integrated the metabolomic transcriptomic analyses light-sensitive variety under different leave color obviously treatments. Totally 140 flavonoid metabolites 2461 genes showed steady change, among which 60 increased accumulation 983 upregulated expression elevated intensity treatment. Light...

Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 DM volunteers. its components defined using diagnostic criteria International Diabetes Federation. Among patients, 113 patients (68.5%) had MetS. Diabetic persons who significantly higher levels (<mml:math...

Bone marrow adipose tissue (MAT) has the potential to exert both local and systemic effects on metabolic homeostasis. As a first-line drug used treat type 2 diabetes mellitus, metformin conflicting MAT bone mesenchymal stem cell (BM-MSC) differentiation. Through series of experiments in vivo vitro, we found that except improving glucose lipid metabolism disorder ob/ob mice, 200 mg/kg increased mice tibia, prompted osteogenic genes (RunX2, OPN, OCN) lipogenic (Ppar-γ, Cebpα, Scd1) expression...

Islet transplantation may potentially cure type 1 diabetes mellitus (T1DM). However, immune rejection, especially that induced by the alloreactive T-cell response, remains a restraining factor for long-term survival of grafted islets. Programmed death ligand-1 (PD-L1) is negative costimulatory molecule. PD-L1 deficiency within donor heart accelerates allograft rejection. Here, we investigate whether in islets reduces time.Glucose Stimulation Assays were performed to evaluate has detrimental...

Purpose The purpose of the study is to test longitudinal efficacy a mHealth intervention (Intergenerational Mobile Technology Opportunities Program, IMTOP) for older type 2 diabetes mellitus (T2DM) patients in rural Taiwan. Few programs targeted adults and effects are unknown. Methods Ninety-seven T2DM aged 55+ were recruited from an outpatient Hualien, comprised 8-week technology self-management training 4-week technical support. College student tutors facilitated learn technology....

With the rise of circular economy, recycling, and upcycling is an emerging sustainable system in fashion industry, emphasising a closed loop “design, produce, use, recycle”. In this context, paper will explore community-based approaches to scale up clothing reuse under social innovation perspective. This study aims establish practice models, which contribute toward promoting greater understanding achieving collaborative cocreation frameworks for community stakeholders. paper, therefore,...

Perilla frutescens (L.), a traditional edible and medicinal crop, contains diverse triterpenes with multiple pharmacological properties. However, the biosynthesis of in perilla remains rarely revelation. In this study, nine putative 2,3-oxidosqualene cyclase (OSC) genes (PfOSC1-9) were screened from P. genome functionally characterized by heterologous expression. Camelliol C, triterpenol effect, was first identified as abundant seeds, camelliol C synthase (PfOSC7) utilizing yeast system....

To examine the prevalence of microalbuminuria (MAU) and chronic kidney disease as well correlation between MAU renal cardiovascular risks Type 2 diabetes mellitus (T2DM) patients for public health policy making in Taiwan. This was a multicenter, hospital-based, randomly selected, cross-sectional study. T2DM aged 18-80 years without known diagnosis proteinuria were eligible. defined urinary albumin-to-creatinine ratio (ACR) within 30-299 mg/g, macroalbuminuria that greater than or equal to...