A5006645742- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Developmental Biology and Gene Regulation
- Genetic Neurodegenerative Diseases
- interferon and immune responses
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Fibrosis and Remodeling
- Gastric Cancer Management and Outcomes
- Viral Infections and Vectors
- Heat shock proteins research
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Zebrafish Biomedical Research Applications
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- Medical Imaging and Pathology Studies
National Health Research Institutes
2017-2024
University of Nottingham
2010-2013
Chung Shan Medical University
2005-2012
Queen's Medical Centre
2010
Background Mitochondrial Lon is a chaperone and DNA-binding protein that functions in quality control stress response pathways. The level of regulates mitochondrial DNA (mtDNA) metabolism the production reactive oxygen species (ROS). However, there little information detail on how ROS-dependent cancer immunoescape through mtDNA tumor microenvironment (TME). Methods We explored understanding intricate interplay between mitochondria innate immune inflammatory TME. Results found oxidized...
Mitochondrial Lon is a chaperone protein whose upregulation increases the production of mitochondrial reactive oxygen species (ROS). However, there lack information in detail on how regulates cancer metastasis through ROS tumor microenvironment (TME). Our results show that elevated promotes epithelial-mesenchymal transition (EMT) via ROS-dependent p38 and NF-κB-signaling. We further identified pyrroline-5-carboxylate reductase 1 (PYCR1) as client Lon, which induces EMT by Lon. inflammatory...
Abstract During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER (endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria-associated membranes (MAM). In mitophagy, ULK1 complex phosphorylates FUNDC1(S17) EMC site. However, how mitochondria sense stress send signal from inside to outside of trigger is still unclear. Mitochondrial Lon was reported be localized under although function remained unknown. this study, we explored mechanism...
Abstract Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how regulates apoptosis through its Accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria and activate in transcription-independent manner. Here we found increased interacts mitochondrial restrains the induced by under oxidative stress rescuing loss membrane potential (Δψm) release...
Abstract Mitochondria are the major organelles in sensing cellular stress and inducing response for cell survival. Mitochondrial Lon has been identified as an important protein involved regulating proliferation, metastasis, apoptosis cancer cells. However, mechanism of retrograde signaling by on mitochondrial DNA (mtDNA) damage remains to be elucidated. Here we report role cisplatin-induced mtDNA oxidative stress, which confers cells cisplatin resistance via modulating calcium levels...
Formation of the organizer is one most central patterning events in vertebrate development. Organizer-derived signals are responsible for establishing CNS and dorsal ventral axis. The mechanisms promoting formation known to involve cooperation between Nodal Wnt signalling. However, forms a very restricted region, suggesting presence that repress its formation. Here, we show zebrafish transcription factor Sox3 represses multiple steps signalling lead Although beta-catenin, Bozozok Squint play...
Cdc7-Dbf4 kinase plays a key role in the initiation of DNA replication and contributes to stress cancer. The activity human remains active acts as an effector checkpoint under stress. However, downstream targets contributed regulation stress-support function cancer are not fully identified. In this work, we showed that aberrant induces lesions activate ATM/ATR-mediated homologous recombination (HR) repair. Using phosphoproteome approach, identified HSP90-S164 target vitro vivo....
Immunotherapy is an emerging cancer therapy with potential great success; however, immune checkpoint inhibitor (e.g., anti-PD-1) has response rates of only 10-30% in solid tumor because the immunosuppressive microenvironment (TME). This affliction can be solved by vascular normalization and TME reprogramming.By using single-cell RNA sequencing (scRNAseq) approach, we tried to find out reprogramming mechanism that Fc-VEGF chimeric antibody drug (Fc-VFD) enhances cell infiltration TME.In this...
Abstract Background Despite having chronic gastritis, most people infected by Helicobacter pylori ( H. ) are asymptomatic and have no specific clinical signs symptoms. infection can be diagnosed several detection methods. Giemsa stain rapid urease test (CLO test) the performed tests of at first‐line examination because their simplicity reliability. However, sensitivity CLO is significantly reduced in patients with atrophic gastritis intestinal metaplasia, weaknesses higher cost...
The organizer is one of the earliest structures to be established during vertebrate development and crucial subsequent patterning embryo. We have previously shown that SoxB1 transcription factor, Sox3, plays a central role as transcriptional repressor zebrafish gene expression. Recent data suggest Fgf signaling has positive influence on formation, but its remains fully elucidated. In order better understand how fits into complex regulatory network determines when where forms, relationship...