A5013990446- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Protease and Inhibitor Mechanisms
- Lymphoma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Intraperitoneal and Appendiceal Malignancies
- Photodynamic Therapy Research Studies
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Urinary and Genital Oncology Studies
- Gastrointestinal disorders and treatments
- Effects and risks of endocrine disrupting chemicals
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
National Defense Medical Center
1998-2024
Tri-Service General Hospital
2013-2024
Taoyuan Armed Forces General Hospital
2015-2024
Ming Chuan University
2016-2024
Taipei Veterans General Hospital
2022-2023
Hsin Sheng College of Medical Care and Management
2022
Creative Commons
2020
VA Long Beach Healthcare System
2020
Oxford University Hospitals NHS Trust
2019
Taipei Medical University
2017
Abstract Purpose: SOX9 is an important transcription factor required for development and has been implicated in several types of cancer. However, never linked to lung cancer date. Here, we show that expression upregulated adenocarcinoma how it associated with cell growth. Experimental Design: Data mining five microarray data sets containing 490 clinical samples, quantitative reverse transcription-PCR validation assay 57 independent immunohistochemistry tissue microarrays 170 cores were used...
Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of mass, quality strength. Age-related (sarcopenia) an important health problem the aged population. We investigated alteration genome-wide transcription mouse tissue (rectus femoris muscle) during aging using high-throughput sequencing technique. Analysis revealed significant transcriptional changes between muscles mice at 3 (young group) 24 (old months age. Specifically, genes energy...
Abstract Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that limit tumor growth are obscure. Here, we report lung cancer populations generate phenotypic and oncogenic plasticity via a switch between programs controlled by SOX2 SOX9, thus altering invasive capabilities. In cells, bound the EPCAM promoter to induce EpCAM–p21Cip1–cyclin A2 signaling, encouraging proliferation as well barrier properties. contrast, SOX9 SLUG SLUG-mediated...
Abstract CISD2 is a redox-sensitive gene critical for normal development and mitochondrial integrity. was known to have aberrant expression in several types of human cancers. However, its relation with lung cancer still not clear. In this study we found mRNA significantly upregulated adenocarcinoma (ADC) samples, compared their adjacent counterparts, correlated tumor stage, grade, prognosis based on analysis clinical specimens-derived data public domain our validation assay. Cell assay...
Daphne genkwa, a Chinese medicinal herb, is used frequently in Southeast Asian countries to treat diseases; the flavonoid hydroxygenkwanin (HGK) extracted from its flower buds. The bioactivity of HGK, particularly as an anti-liver cancer agent, has not been explored. In this study, human hepatocellular carcinoma (HCC) cell lines and animal xenograft model were employed investigate both activity HGK against liver cellular signaling mechanisms. HCC cells treated with subjected function assays....
Objective: This study aimed to evaluate the associations between lifestyle factors and estimated glomerular filtration rate (eGFR) levels in older adults by analyzing United States National Health Nutrition Examination Survey data (1999–2016). Methods: A total of 10,052 eligible participants were divided into two groups: reduced eGFR group (eGFR < 60 ml/min/1.73 m 2 ) normal ≥ ). The primary physical activity, alcohol consumption, smoking, comorbidities. Results: Multivariable...
Melatonin is the main pineal hormone that relays light/dark-cycle information to circadian system. Recent studies have examined intrinsic antitumor activity of melatonin in various cancers, including hepatocellular carcinoma (HCC), primary life-threatening malignancy both sexes Taiwan. However, detailed regulatory mechanisms underlying melatonin’s anti-HCC remain incompletely understood. Here, we investigated by which regulated. Human hepatoma cell lines were treated with 1 and 2 mM...
Although it is known that high uric acid (UA) level associated with type 2 diabetes (T2DM) and metabolic syndrome (MetS), most of the previous studies were focused on adults. Since aging becomes a major problem for many societies, in this longitudinal study, we investigated role UA future T2DM MetS large cohort people who older than 65 years.
The use of cisplatin (CDDP), the most common chemotherapy drug for head and neck cancer, is limited by its undesirable side effects, especially nephrotoxicity. We investigated ultrasound microbubbles (USMB) as a tool to increase local intra-tumoral CDDP level while decreasing systemic cytotoxicity. allowed interact with human serum albumin then sonicated resulting CDDP‒albumin complex generate CDDP-loaded MBs (CDDP-MBs). established head-and-neck tumor-bearing mouse model implanting...
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia.Subjects with type 2 diabetes (T2D) exhibit features of MetS.The etiology MetS is complex, involving both environmental genetic factors.In this study, we examined the Genetic variants metabolic in ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (1
Human platelet antigen (HPA) systems consist of more than twelve bi-allelic polymorphisms in which a base pair substitution leads to change an amino acid glycoprotein expressed on the platelet. The neonatal alloimmune thrombocytopenia (NAIT), post transfusion purpura, and refactoriness can be induced by antibodies against human antigens: e.g. HPA-1a, 3a, 4a, 5a, Gova. HPA typing is essential for diagnosis treatment variety diseases. We developed PCR-based method detect HPA-1 HPA-13, Oe Gov...
Aberrant insulin-like growth factor-binding protein 7 (IGFBP-7) expression has been found in various cancers such as prostate, breast, and colon. IGFBP-7 induced the apoptosis of tumor potentially predicted clinical outcome some is further demonstrated. This study investigates causes underlying mechanisms aberrant unravelling head neck squamous cell carcinoma (HNSCC). A total 47 oral tongue cancer patient samples were primarily analyzed for methylation status 5′ region by...
Impaired kidney function is the hallmark of chronic disease (CKD), and associated with increased risk all-cause mortality in elderly. In present cross-sectional population-based study, we aimed to evaluate associations between lifestyle factors (exercise habit, alcohol consumption, smoking history, betel nut chewing) decreased function.
Megadose of vitamin C (MVC) has been proposed for an emergent treatment acute paraquat (PQ) poisoning. However, the safety issue this protocol not evaluated. Here, we present first evidence that can promote aggravated production hydroxyl radical (OH•) via interacting with preexisting PQ+•/H2O2 system in a nonmetal-catalyzed manner. This enhanced oxidative stress would therefore expect to cause more deleterious effect during PQ intoxication. To lend support possibility, set out attest effects...
This cross-sectional study aimed to compare risk factors for chronic kidney disease (CKD) in older adults with or without dyslipidemia and/or cardiovascular diseases (CVD) Taipei City, Taiwan. The data on 2912 participants hyperlipidemia CVD and 14,002 healthy control derived from the City Elderly Health Examination Database (2010 2011) were analyzed. associations between conventional CKD comparable hyperlipidemia. Participants high uric acid BUN had a higher of if they also [odds ratio (OR)...
Bile duct carcinomas have been reported in domestic cats and dogs [8], cattle sheep [8, 111, goats [3], chickens [9], pigeons [12], various zoo animals birds [2, 4, 6, 101. Cycasin-induced, transplantable bile hamsters shown to be associated with virus-like particles [7]. In man, about 4500 deaths occur each year the United States as result of biliary tract neoplasms this report we describe a cholangiocarcinoma metastases margay (Felis wiedii). The is small, feral feline found from Mexico...