A5040081412- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Genetic Mapping and Diversity in Plants and Animals
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Statistical Methods and Inference
- Gene Regulatory Network Analysis
- Statistical Methods and Bayesian Inference
- Genetic and phenotypic traits in livestock
- Dental Radiography and Imaging
- Cancer-related molecular mechanisms research
- Endodontics and Root Canal Treatments
- Mental Health Research Topics
- Axon Guidance and Neuronal Signaling
National Taiwan University
2016-2025
National Taiwan University Hospital
2004-2023
Taipei City Government
2011
Taichung Veterans General Hospital
2010
McMaster University
2010
University of California, Berkeley
2006
Genomics Research Center, Academia Sinica
2006
Tzu Chi University
2004-2006
Taipei Medical University
2006
Fu Jen Catholic University
2006
The presence of hepatitis B e antigen (HBeAg) in serum indicates active viral replication hepatocytes. HBeAg is thus a surrogate marker for the virus DNA. We conducted prospective study to determine relation between positivity surface (HBsAg) and development hepatocellular carcinoma.
Introduction: To determine time trends in myopia over a 20-year period Taiwan, we conducted 5 nationwide surveys pertaining to the ocular refraction of schoolchildren 1983, 1986, 1990, 1995 and 2000. Materials Methods: The sampling technique used herein involved assessment stratified systematic clusters, with unweighted myopic rate being represented using data derived from different sectors population, such as metropolitan, city, town, aboriginal. mean values for spherical equivalent...
Background Many prediction tools for microRNA (miRNA) targets have been developed, but inconsistent predictions were observed across multiple algorithms, which can make further analysis difficult. Moreover, the nomenclature of human miRNAs changes rapidly. To address these issues, we developed a web-based system, miRSystem, converting queried to latest annotation and predicting function miRNA by integrating target gene function/pathway analyses. Results First, IDs converted annotated version...
Abstract Background: Although cigarette smoking is the major risk factor for lung cancer, only 7% of female cancer patients in Taiwan have a history smoking. The genetic mechanisms carcinogenesis nonsmokers are unclear, but semaphorins been suggested to play role as tumor suppressors. This report comprehensive analysis molecular signature nonsmoking Taiwan, with particular focus on semaphorin gene family. Methods: Sixty pairs and adjacent normal tissue specimens were analyzed by using...
The authors examined cross-cultural applicability of the Schizotypal Personality Questionnaire (SPQ), Perceptual Aberration Scale (PAS), and Continuous Performance Test in community samples Taiwanese adults adolescents. tested hypotheses that a 3-factor structure SPQ (Cognitive-Perceptual, Interpersonal, Disorganization: A. Raine et al., 1994) exists for both Interpersonal factor is associated with poorer attention. replicated model samples, they externally validated adults: possibly...
Since brain tissue is not readily accessible, a new focus in search of biomarkers for schizophrenia blood-based expression profiling non-protein coding genes such as microRNAs (miRNAs), which regulate gene by inhibiting the translation messenger RNAs. This study aimed to identify potential miRNA signature comparing genome-wide profiles patients with vs. healthy controls. A was performed using Taqman array 365 human miRNAs mononuclear leukocytes learning set 30 cases and The discriminating...
ABSTRACT. Purpose: This randomized clinical trial assessed the treatment effects of atropine and/or multi‐focal lenses in decreasing progression rate myopia children. Methods: Two hundred and twenty‐seven schoolchildren with myopia, aged from 6 to 13 years, who were stratified based on gender, age initial amount randomly assigned three groups: 0.5% glasses, single vision spectacles. Each subject was followed for at least eighteen months. These results report 188 patients available follow‐up....
<h3>Background and aims</h3> The associations between long-term risk of hepatocellular carcinoma (HCC) spontaneous seroclearance HBV e antigen (HBeAg), DNA surface (HBsAg) have never been examined by a prospective study using serially measured seromarkers. This aimed to assess the importance HBeAg, HBsAg in prediction HCC risk. <h3>Methods</h3> included 2946 seropositive individuals who were seronegative for antibodies against HCV free liver cirrhosis. Serial serum samples collected at entry...
PurposeThe aim of this study was to evaluate the changes in prevalence myopia Taiwanese schoolchildren over past few decades and analyze risk factors for myopia.DesignAnalysis 8 consecutive population-based surveys conducted from 1983 through 2017.ParticipantsAn average 8917 (5019–11 656) 3 18 years age were selected using stratified systematic cluster sampling or by probability proportional size sampling.MethodsAll participants underwent complete ophthalmic evaluations. Three drops 0.5%...
The Continuous Performance Test (CPT) has been modified to be used widely as a potential vulnerability marker of schizophrenia. In genetic analyses schizophrenia, well-established norms for the CPT are essential in choosing suitable threshold classifying subjects affected or unaffected. this study, we investigated performance 115 adolescents and 345 adults, randomly sampled from community, on two sessions 1–9 (undegraded 25% degraded). results showed that an older age was associated with...
Background: Previous studies have shown the presence of serum anti‐nuclear (ANA), anti‐smooth muscle (SMA), anti‐mitochondrial (AMA), anti‐gastric parietal cell (GPCA), anti‐thyroglobulin (TGA) and anti‐thyroid microsomal autoantibodies (TMA) in small groups patients with oral lichen planus (OLP). Methods: In this study, levels ANA, SMA, AMA, GPCA, TGA TMA were measured a group 320 Chinese OLP 53 healthy control subjects to assess whether had significantly higher frequencies than which risk...
Background Triple-negative breast cancer is a subtype of with aggressive tumor behavior and distinct disease etiology. Due to the lack an effective targeted medicine, treatment options for triple-negative are few recurrence rates high. Although various multi-gene prognostic markers have been proposed prediction outcome, most them were proven clinically useful only estrogen receptor-positive cancers. Reliable identification patients favorable prognosis not yet possible. Methodology/Principal...
To assess the clinical pictures, possible pathogenesis, management, and therapy of patients with infectious scleritis associated multifocal scleral abscesses following pterygium excision.The records after excision who developed presenting from 1988 to end 1995 were reviewed. Early culture was performed, topical, systemic antimicrobials, or both given all patients. Fourteen eyes operated on in addition antimicrobial treatment.The initial reports ulcers identified Pseudomonas species 12 these...