Abstract Abstract: Dietary polyphenols, including anthocyanins, are suggested to be involved in the protective effects of fruits and vegetables against cancer. However, anticancer peonidin 3-glucoside have not been clearly demonstrated, with only limited studies being available concerning inhibitory effect cyanidin for tumor cell growth. Therefore, this study, we isolated identified two bioactive compounds, 3-glucoside, from Oryza sativa L. indica, treat various cancer cells. The results...

Background Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease cancer. Based on this finding, we investigated the mechanisms by which produces anti-metastatic effect human tongue squamous cell carcinoma SCC4 cells. Methodology/Principal Findings In study, provided molecular evidence associated with of...

Metastasis is the most common cause of cancer-related death in patients, and epithelial-to-mesenchymal transition (EMT) essential for cancer metastasis, which a multistep complicated process that includes local invasion, intravasation, extravasation, proliferation at distant sites. When cells metastasize, angiogenesis also required metastatic dissemination, given an increase vascular density will allow easier access tumor to circulation, represents rational target therapeutic intervention....

Protodioscin (PD) is a steroidal saponin with anti-cancer effects on number of cancer cells, but the anti-tumor and mechanism action PD human cervical cells unclear.We determined cell viability using MTT assay. Cell death, mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress were measured flow cytometry. Caspase activation, ER stress, MMP-dependent apoptosis proteins in response to by Western blot analysis. The...

Cancer metastasis, involving multiple processes and various cytophysiological changes, is a primary cause of cancer death may complicate the clinical management, even lead to death. Silibinin flavonoid antioxidant wildly used for its antihepatotoxic properties recent studies have revealed pleiotropic anticancer antiproliferative capabilities silibinin. In this study, we first observed that silibinin exerted dose- time-dependent inhibitory effect on invasion motility, but hardly adhesion,...

Epithelial to mesenchymal transition (EMT) is critical for the progression, invasion, and metastasis of epithelial tumorgenesis. Here, we provided molecular evidence associated with antimetastatic effect green tea polyphenol epigallocatechin-3 gallate (EGCG) in an oral squamous cell culture system by showing a nearly complete inhibition on invasion (P < 0.001) carcinoma-9 (SCC-9) cells via reduced expression matrix metalloproteinase-2 urokinasetype plasminogen activator 0.001). EGCG exerted...

Scope Recent reports have demonstrated that head and neck cancer‐derived tumor‐initiating cells (HNC‐TICs) presented high tumorigenic, chemoradioresistant, metastatic properties, were coupled with gain of epithelial–mesenchymal transition (EMT) characteristics. The aim this study was to investigate the chemotherapeutic effect regulatory mechanisms resveratrol on HNC‐TICs. Methods results We first observed treatment significantly downregulated ALDH1 activity CD44 positivity cancer (HNC) in a...

Background Thymoquinone (TQ), an active component of Nigella sativa or black cumin, elicits cytotoxic effects on various cancer cell lines. However, the anti-cancer TQ head and neck squamous carcinoma (HNSCC) remain unclear. Methodology/Principal Findings In this study, elicited a strong effect SASVO3, highly malignant HNSCC line. The mechanisms were concentration dependent. also induced apoptotic death in SASVO3 cells as indicated by increase Bax expression caspase-9 activation. Apoptosis...

// Cheng-Chia Yu 1, 2, 3, 4 , Pei-Ni Chen 5, * Chih-Yu Peng 4, Chuan-Hang Ming-Yung Chou 1 Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan 2 School Dentistry, 3 Department University Hospital, Medicine Research Center, 5 Biochemistry, Microbiology and Immunology, These authors have contributed equally to this work Correspondence to: Chou, e-mail: myc@csmu.edu.tw Yu, tao2008@csmu.edu.tw Keywords: oral squamous cell carcinomas, miR-204, stemness, EMT, metastasis...

Kaempferol, which is isolated from several natural plants, a polyphenol belonging to the subgroup of flavonoids. Kaempferol exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this study, kaempferol can significantly inhibit invasion migration 786-O renal cell carcinoma (RCC) without cytotoxicity. We examined potential mechanisms underlying its anti-invasive activities on RCC cells. Western blot was performed,...

Abstract Glioblastoma (GBM) is the most mortality brain cancer in world. Due to high invasion and drug resistance cause poor prognosis of GBM. Naringenin, an ingredient citrus, exhibits many cellular functions such as antioxidant, anti‐inflammation, anticancer. Naringenin inhibits migration bladder lung via modulation MMP‐2 and/or MMP‐9 activities, trigger apoptosis gastric cells through downregulation AKT pathway. However, effects naringenin GBM still remain be elucidated. In this study, we...

The oxidative modification of low-density lipoprotein (LDL) is thought to have a central role in the pathogenesis atherogenesis. Berberine, natural constituent plants genera Coptis and Berberis, has several anti-inflammation anticancer biological effects. However, its protective effects on LDL oxidation endothelial injury induced by oxLDL remain unclear. In this study, we evaluated antioxidative activity berberine how rescues human umbilical vein cells (HUVECs) from oxidized (oxLDL)-mediated...

Anthocyanins, present in various vegetables and fruits as a nature colorant, have broad activities including anticarcinogenesis antimutagenesis, which are generally attributed to their antioxidant activities. However, limited studies been available concerning the inhibitory effect of peonidin 3-glucoside (P3G) for cancer metastasis. Here, we demonstrated that P3G could significantly inhibit invasion (P < 0.001), motility 0.05), secretion matrix metalloproteinase (MMP)-2, MMP-9,...

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has very poor prognosis with over 5-year survival rate only 50%. Thus, it important to identify effective therapeutic interventions against oral cancer. Apoptosis and autophagy have reported genetically regulated in physiology diseases, which close relationship. Many natural compound study objects anticancer effect been studied between apoptosis The present was designed evaluate the erianin on human...

Genistein, a soy-derived phytoestrogen, has been shown to exhibit anti-neoplastic activities in various cancers. Nevertheless, its effects on the elimination of tumor-initiating cells head and neck cancer (HNC-TICs) remain unclear. Here, we investigated inhibitory effect genistein HNC-TICs potential mechanisms. Our results demonstrated that lowered proliferation by examining percentage ALDH1+ or CD44+ cells. Aside from downregulation epithelial-mesenchymal transition (EMT) HNC-TICs,...

Metastasis is the most prevalent cause of cancer-related deaths and treatment failure in patients with hepatocellular carcinoma (HCC). Kaempferol a natural flavonol belonging to subgroup flavonoids exhibits potent anticancer activities. This study provides molecular evidence on anti-invasive anti-migratory effects kaempferol human HCC cells. The effect was investigated by applying two cell lines (Huh-7 SK-Hep-1). reduced invasion migration Huh-7 SK-Hep-1 cells Boyden chamber assay wound...

Carbonic anhydrase IX (CAIX) is a hypoxia-induced protein that highly expressed in numerous human cancers. However, the molecular mechanisms involved CAIX and cervical cancer metastasis remain poorly understood. In this study, overexpression SiHa cells increased cell migration epithelial-to-mesenchymal transition (EMT). Silencing Caski line decreased motility of EMT. Furthermore, RNA-sequencing analysis identified target gene, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase...

Arctiin, a lignan glycoside, is isolated from Arctium lappa L. The anticancer effects of arctiin have been demonstrated in several studies. However, no research has conducted on the anti-migration effect cervical cancer cells. present study examined cells and investigated possible molecular mechanism. We that exhibited low cytotoxicity significantly inhibited cell migration invasion human S100A4 protein expression mRNA levels were reduced HeLa SiHa with treatment. Furthermore, silencing by...