Abstract Scope: Hepatocellular carcinoma is the most common type of liver cancer and highly metastatic. Metastasis considered to be major cause death in patients. Ginger a natural dietary rhizome with anti‐oxidative, anti‐inflammatory, anti‐carcinogenic activities. The aims this study were evaluate anti‐invasion activity 6‐shogaol 6‐gingerol, two compounds found ginger, on hepatoma cells. Methods results: migratory invasive abilities phorbol 12‐myristate 13‐acetate (PMA)‐treated HepG2...

Ganoderma lucidum has been reported to be associated with suppressed motility, invasion and metastasis of several types cancers, but its mechanism action remains unclear. In our previous study, lucidenic acids A, B, C N were isolated from a new strain G.lucidum all them found have potential anti-invasive activity on phorbol-12-myristate-13-acetate (PMA)-induced HepG 2 cells by suppressing the matrix metalloproteinase (MMP)-9 activity. Here, acid B (LAB) was used explore mechanisms underlying...

Scope We previously demonstrated that 6‐shogaol and 6‐gingerol, two active compounds in ginger ( Zingiber officinale ), possess antiinvasive activity against highly metastatic hepatoma cells. The aims of this study were to evaluate the inhibitory effect molecular mechanism underlying transcription translation matrix metalloproteinases (MMPs) urokinase‐type plasminogen activator (uPA) Hep3B cells as well antiangiogenic 6‐gingerol 6‐shogaol. Methods results By gelatin zymography luciferase...

Aortic stenosis (AS) is a fatal cardiovascular disease characterized by an inflammatory response. Blepharitis and hordeolum are two eyelid conditions that also involve ocular inflammation. The aim of this study to assess the association between AS subsequent development diseases. This retrospective cohort included individuals diagnosed with AS, who were matched control group non-AS from TriNetX database. A total 431,027 assigned both groups. primary outcomes incidence rates diseases,...

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and also highly metastatic. Metastasis considered to be major cause death in patients. Resveratrol (3,5,4′-trihydroxystilbene) related analogues have been reported as candidates prevent growth invasion. The bioactivity resveratrol-related could altered due presence positioning methoxy groups on basic resveratrol chemical structure. This study investigated effects mechanism action its invasion human hepatocarcinoma cells....

Natural bioactives or phytochemicals are generally referred to as the compounds that have specific biological activity in human. Studies shown natural derived from certain plants capability prevent carcinogenesis. In this special issue, we collected numerous studies which provide novel evidence support opinion. For instance, [6]-gingerol prevents disassembly of cell junctions and activities MMPs invasive human pancreas cancer cells; butein inhibits angiogenesis endothelial progenitor...

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has very poor prognosis with over 5-year survival rate only 50%. Thus, it important to identify effective therapeutic interventions against oral cancer. Apoptosis and autophagy have reported genetically regulated in physiology diseases, which close relationship. Many natural compound study objects anticancer effect been studied between apoptosis The present was designed evaluate the erianin on human...

Ganoderma lucidum is a well-known mushroom with various pharmacological effects that has been used for health and longevity purposes. The objective of this study was to investigate the anti-invasive effect lucidenic acids isolated from new G. strain (YK-02) against human hepatoma carcinoma (HepG(2)) cells. Triterpenoid components in ethanol extract were separated by means semi-preparative RP HPLC. Four major peaks crystallized triterpenoids fraction, identified as A, B, C, N according their...

Resveratrol (3,5,4'-trihydroxystilbene) is a natural polyphenol that presents various physiological activities. It has been reported the methylated derivatives of resveratrol show better potential antifungal and antiproliferative activities than resveratrol. In present study, we investigated inhibitory effect 3,5,4'-trimethoxy-trans-stilbene (MR-3), derivative resveratrol, on invasion A549 cells (a human lung adenocarcinoma cell line). We found treatment with MR-3 at concentration 5 muM...

Metastasis is considered to be the major cause of death in patients with cancers, and hepatocellular carcinoma (HCC) a highly metastatic cancer. Ganoderma lucidum , well-known mushroom various biological effects, functional food known contain lucidenic acid. The objectives this study were investigate anti-invasion effect acid-rich G. extract (GLE) on human hepatoma HepG2 cells as well antiproliferative antimetastatic effects GLE implanted into ICR-nu/nu mice. Phorbol-12-myristate-13-acetate...

While lung cancer accounts for approximately 20% of diagnoses, it is the leading cause tumor-related deaths. The apoptotic effects 3,5,4′-trihydroxystilbene (resveratrol), dibenzoylmethane (DBM), and their analogues on human cells are generally unclear. aims this study were to evaluate molecular mechanisms resveratrol, DBM, cells. results MTT lactate dehydrogenase (LDH) leakage assays indicated that 3,5,4′-trimethoxy-trans-stilbene (MR-3),...

Patients with lung adenocarcinoma are often diagnosed metastasizing symptoms and die of early distal metastasis. Metastasis is made up a cascade interrelated sequential steps, including cell adhesion, extracellular matrix degradation, movement, invasion. Hence, substances carrying the ability to stop one metastasis-associated steps could be potential candidate for preventing tumor cells from prolonging life cancer patients. Cinnamic acid (CA) was demonstrated such human cells. Nevertheless,...

Glabridin, a flavonoid extracted from licorice (Glycyrrhiza glabra), possesses various biological properties, including anticancer activities. However, the effect of glabridin on oral cancer cell apoptosis and underlying molecular mechanisms has not been elucidated. In this study, we demonstrated that treatment significantly inhibits proliferation in human SCC-9 SAS lines. Flow cytometric assays induced several features apoptosis, such as sub-G1 phase increase phosphatidylserine...

Scope Oxidative stress‐aggravated chronic inflammatory diseases of the airway are well documented; hence, treatment with antioxidants to ameliorate oxidative stress might be an effective strategy reduce complications. The aim this study was investigate effect and molecular mechanism diallyl sulfide ( DAS ), which is a natural organosulfuric compound found in garlic, on inhibition tumor necrosis factor‐alpha TNF ‐α)‐ or histamine‐induced inflammation rat aortic smooth muscle A 7r5 cells....

In Taiwan, oral cancer is causally associated with environmental carcinogens. Survivin an anti-apoptotic protein and generally considered a marker of malignancy. The current study explored the combined effect survivin gene polymorphisms carcinogens on risk clinico-pathological development cancer. Five single-nucleotide (SNPs) genes from 439 male patients 424 control participants (who did not have cancer) were analyzed. −31GG, +9194 GG, +9809 TT homozygotes exhibited higher for compared...