A5039567335- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Pharmacovigilance and Adverse Drug Reactions
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Eosinophilic Disorders and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Digestive system and related health
- Cancer-related gene regulation
- Lipid metabolism and disorders
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Oral Health Pathology and Treatment
- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Metabolism, Diabetes, and Cancer
- Lysosomal Storage Disorders Research
- Magnolia and Illicium research
- Advanced Glycation End Products research
Chang Gung Memorial Hospital
2015-2025
Chang Gung University
2014-2025
Texas A&M University System
2010
Institute of Molecular Biology, Academia Sinica
2008
Institute of Biomedical Sciences, Academia Sinica
2008
National Yang Ming Chiao Tung University
2006
BACKGROUND. Cytotoxic T lymphocyte–mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, TNF-α granulysin, were observed in SJS-TEN patients recent studies, the optimal treatment for these diseases remains controversial. We aimed to evaluate efficacy, safety,...
Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent Asia.The survival rate OSCC patients has not improved over past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes.Improvement therapeutic strategies tailored options unmet need.To unveil mutational spectrum, whole-exome sequencing 120 from male individuals Taiwan was conducted.Analyzing contributions five signatures extracted...
<h3>Objective:</h3> To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese Thai). <h3>Methods:</h3> We prospectively enrolled patients with OXC-cADRs Taiwan Thailand from 2006 to 2014, analyzed clinical course, latent period, drug dosage, organ involvement, complications, mortality. also investigated carrier rate <i>HLA-B*15:02</i>...
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies medication related to SJS/TEN Asian populations. Thus, we analyzed registration databases from multiple countries who were treated during 1998–2017. A total 1,028 cases identified algorithm drug causality for necrolysis. Furthermore, those medications labeled...
// Chia-Ming Yeh 1 , Chiao-Wen Lin 2, 3 Jia-Sin Yang 1, 4 Wei-En Shih-Chi Su 5 Shun-Fa Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan 2 Oral Sciences, Department Dentistry, University Hospital, Research, Whole-Genome Research Core Laboratory Human Diseases, Chang Gung Memorial Keelung, Correspondence to: Yang, e-mail: ysf@csmu.edu.tw Keywords: melatonin, oral cancer, MMP, CREBBP, EP300 Received: December 18, 2015 Accepted: February 23, 2016 Published: March 09,...
Abstract Background and Objectives The aim of this study was to examine the potential associations two hypoxia inducible factor‐1α (HIF‐1α) gene polymorphisms, C1772T G1790A, with susceptibility clinicopathological status hepatocellular carcinoma. Methods A total 449 subjects, including 347 healthy controls 102 patients carcinoma, were recruited in subjected polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) analyses estimate impact these polymorphic variants on...
Oral squamous cell carcinoma is a common neoplasm that known to be causally associated with genetic factors and environmental carcinogens. The receptor for advanced glycosylation endproducts (RAGE) transmembrane protein of the immunoglobulin superfamily broad specificity multiple ligands, it has been shown play vital roles in several pathophysiologic processes, including diabetes, Alzheimer disease, renal cardiovascular cancer. present study aimed assess influences RAGE gene polymorphisms,...
The coronary heart disease (CHD) can influence the development of several diseases. presence CHD is correlated to a higher incidence concurrent diabetic retinopathy (DR) in previous study. Herein, we aim analyze relationship between severity and following DR with different severity. A retrospective cohort study was conducted usage Taiwan National Health Insurance Research Database (NHIRD). patients DM were categorized into those medical treatments received percutaneous intervention (PCI)...
Background/Aim: Pentraxin 3 (PTX3), initially discovered as a key player in the defense against infectious pathogens, is crucial for inflammation and tissue regeneration. This study aimed to explore impact of <i>PTX3</i> gene variants on development progression diabetic neuropathy (DN). Materials Methods: The potential susceptibility DN was examined by genotyping four single-nucleotide polymorphisms (SNPs) (rs1840680, rs2305619, rs3816527, rs2120243) involving 730 cases 861 controls with...