A5026294143- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Adverse Reactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autoimmune Bullous Skin Diseases
- Cancer Research and Treatments
- Urticaria and Related Conditions
- Ferroptosis and cancer prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Multiple and Secondary Primary Cancers
- Advanced Nanomaterials in Catalysis
- Hair Growth and Disorders
- Allergic Rhinitis and Sensitization
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- Mast cells and histamine
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Biosensors and Analytical Detection
- Radiomics and Machine Learning in Medical Imaging
Chang Gung Memorial Hospital
2018-2024
First Affiliated Hospital of Fujian Medical University
2010-2024
Fujian Medical University
2010-2024
National Taiwan University
2022-2024
Chang Gung University
2018-2024
Linkou Chang Gung Memorial Hospital
2022
Keelung Chang Gung Memorial Hospital
2022
Mengchao Hepatobiliary Hospital
2015
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies medication related to SJS/TEN Asian populations. Thus, we analyzed registration databases from multiple countries who were treated during 1998–2017. A total 1,028 cases identified algorithm drug causality for necrolysis. Furthermore, those medications labeled...
BackgroundThe synergistic effect of locoregional therapy in combination with systemic as a conversion for unresectable hepatocellular carcinoma (uHCC) is unclear. The purpose this study was to evaluate the efficacy and safety transcatheter arterial chemoembolisation (TACE) combined lenvatinib camrelizumab (TACE + LEN CAM) uHCC.MethodsThis single-arm, multicentre, prospective conducted at nine hospitals China. Patients (aged 18–75 years) diagnosed uHCC, an Eastern Cooperative Oncology Group...
Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use due to potential toxicities, including severe leukopenia. Recent studies have identified genetic NUDT15 variants strongly associated with AZA-induced leukopenia in Asian patients. This study aimed investigate strength above association and evaluate usefulness prospective screening prevent Chinese patients disorders were enrolled from multiple medical centers Taiwan/China between...
Abstract Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening cutaneous conditions. However, studies of pediatric SJS/TEN limited. To investigate the causes, clinical course, outcomes complications SJS TEN in children. This retrospective study included 47 patients (aged < 18 years) with SJS, SJS/TEN, or treated at Chang Gung Memorial Hospital, Taiwan, between January 2009 December 2019. ALDEN scores serological tests were used to assess causes SCORTEN...
Background: The aim of this study is to explore the mechanism HRAS and HSPB1 in ferroptosis. Primary liver cancer third leading cause tumor death worldwide. Hepatocellular carcinoma (HCC) constitutes 75%-85% cases primary cancer. co-express multiple cells participate progression regulation. However, their expression regulation role HCC have not been reported. Methods: We investigated effects on ferroptosis vitro experiments. Here, were by transfecting specific siRNA or overexpressing...
Abstract Background As a drug-induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) is potentially fatal. Most patients DRESS recover within few weeks; however, some may suffer from prolonged disease course develop autoimmune sequelae. Objectives To investigate the immune mechanism therapeutic targets of recalcitrant course. Methods Thirty-two treatment (≥ 8 ‘prolonged DRESS’), 28 short (&lt; 2 ‘short-duration DRESS’) 26 healthy donors (HDs)...
Hepatocellular Carcinoma (HCC) is one of the most common malignant tumor, which causing second leading cancer-related death worldwide. The tumor tissues and adjacent noncancerous obtained from HCC patients with single multiple lesions were quantified using iTRAQ. A total 5513 proteins (FDR 1%) identified correspond to roughly 27% liver proteome. And 107 330 dysregulated in tissue (MC group) a lesion (SC group), compared their (MN SN respectively. Bioinformatics analysis (GO, KEGG IPA)...
To determine phenotype-related dupilumab response in adult patients with atopic dermatitis (AD), this multicenter, retrospective study included 111 adults moderate-to-severe AD Taiwan, median age of 31.5 years (18-87) and 71 (64.0%) males. Patients received 300 mg per two to three weeks up 12 months. We found a significant improvement after 4 16 treatment all for the assessed scores, including eczema area severity index (EASI) ≥50% (EASI-50) 75% (EASI-75), EASI reaching minimal clinically...
Previous studies have reported a close connection between the spleen and hepatic tumours. We investigated prognostic value of postoperative splenic volume increase (PSVI) in patients with hepatocellular carcinoma after curative hepatectomy.This was retrospective study adult who underwent hepatectomy January 2007 May 2013. categorized into 2 groups according to cut-off receiver operating characteristic curve: group A (PSVI < 19.0%) B ≥ 19.0%). compared clinicopathological data, overall...
Objective To investigate the clinical efficacy of laparoscopic hepatectomy.Methods The data 258 patients who received hepatectomy at First Affiliated Hospital Fujian Medical University from March 2010 to January 2013 were retrospectively analyzed.There 196 with primary hepatic cancer,45 hemangioma,13 focal nodular hyperplasia,2 metastatic cancer,1 carcinoma gallbladder and 1 hamartoma.All followed up via phone call or out-patient examination till 2013.Results A total 142 single...
Objective To investigate the clinicopathologic characteristics of intra-hepatic recurrent hepatocelluar carcinoma with solitary tumor node.Methods A series 96 patients were investigated retrospectively.These divided into node group (46 cases) and multiple nodes (50 according to number nodes.Two groups compatible in 10 indicators 3 immunohistochemisty indicators.Results The cases diameter less than 5 cm accounted for 67.4％ (31/46) group,and was 34.0％ (17/50) group.The without microvascular...
Objective To calculate the residoal liver volume using a virtaal surgery planning system,and to investigate value of standardized estimated remnant ratio (STELR) in prcdicting hepatic dysfunction after hepatectomy.Methods The clinical data 76 patients with primary cancer who were admitted First Affiliated Hospital Fujian Medical University from April 2007 October 2011 retrospectivcly analyzed.The virtual resection and residual measurements carried out Liv 1.0 software.The STELR predicting...
Objective To evaluate the feasibility and efficacy of laparoscopic liver resection (LLR) in elderly patients with hepatocellular carcinoma (HCC). Methods Twenty-nine undergoing 58 receiving open (OLR) for HCC were included from January 2013 to December 2015 our department Fujian Medical University.Two groups 1∶2 matched gender, tumor numbers, operative procedure.Besides, general clinical data, intraoperative postoperative recovery, survival compared. Results The hospital stay...
Objective Using comparative proteomic approach to analyze proteins relevant the recurrence of large hepatocellular carcinoma (HCC). Methods The HCC samples group R≤6 m (n=9), R6-12 R>24 (n=6) were analyzed using technique isobaric tags for relative and absolute quantification (iTRAQ)-two dimensional liquid chromatography tandem mass spectrometry (2DLC-MS/MS). The differentially expressed confirmed by real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) Western...