A5101873983- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders Research
- Pancreatitis Pathology and Treatment
- Multiple Myeloma Research and Treatments
- Contact Dermatitis and Allergies
- Peripheral Neuropathies and Disorders
- Pharmacogenetics and Drug Metabolism
- Hepatitis C virus research
- Endometrial and Cervical Cancer Treatments
- Biosimilars and Bioanalytical Methods
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Marine and coastal plant biology
- Electrospun Nanofibers in Biomedical Applications
- Facial Trauma and Fracture Management
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- bioluminescence and chemiluminescence research
British Columbia Children's Hospital
2020-2025
University of British Columbia
2020-2025
China Medical University
2021
Feng Chia University
2021
Chang Gung Memorial Hospital
2020
Linkou Chang Gung Memorial Hospital
2020
National Yang Ming Chiao Tung University
2013-2019
National Health Research Institutes
2018
Institute of Pharmacology
2016
Shandong Agricultural University
2010
Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes life-threatening severe cutaneous adverse reactions (SCAR), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS) toxic epidermal necrosis (TEN). The prognostic factors for allopurinol-related SCAR remain unclear. This study aimed to investigate relationship dosing, renal function, plasma levels oxypurinol granulysin (a cytotoxic protein SJS/TEN), disease severity...
<h3>Objective:</h3> To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese Thai). <h3>Methods:</h3> We prospectively enrolled patients with OXC-cADRs Taiwan Thailand from 2006 to 2014, analyzed clinical course, latent period, drug dosage, organ involvement, complications, mortality. also investigated carrier rate <i>HLA-B*15:02</i>...
Rhein, an anthraquinone drug, is a widely used traditional Chinese medicine. Rhein major bioactive metabolite of diacerein which has been approved for treating osteoarthritis with good safety profile in humans. Gouty arthritis inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation up-regulated caspase-1 protease and IL-1[Formula: see text] macrophages. Inhibition the formation considered as potential therapeutic avenue or preventing many diseases. This...
ABSTRACT Background L‐asparaginase is essential in treating pediatric acute lymphoblastic leukemia (ALL) but limited by hypersensitivity reactions up to 70% of patients, leading severe, dose‐limiting complications and compromised event‐free survival. Procedure This study conducted a genome‐wide association (GWAS) discovery cohort 221 cancer patients who experienced l‐asparaginase–induced (≥CTCAE grade 2) 705 controls without despite equivalent exposure. Results were replicated an independent...
Objective. Gout is characterized by recurrent attacks of arthritis with hyperuricaemia and urate crystal-induced inflammation. Although transporters are known as risk factors, the immunogenetics gouty inflammation remains unclear. This study aimed to investigate genetic association between immune/metabolism regulators gout. Methods. We enrolled 448 gout patients 943 population controls from Taiwan; all were Han Chinese. screened 22 variants candidate genes, including NLRP3, caspase 1,...
Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed detect variants associated with this adverse reaction.
Biomaterials are widely used for effectively controlling bleeding in oral/dental surgical procedures. Here, gelatin methacryloyl (GelMA) was synthesized by grafting methacrylic anhydride on backbone, and phenyl isothiocyanate-modified (Gel-Phe) conjugating different gelatin/phenyl isothiocyanate molar ratios (G/P ratios) (i.e., 1:1, 1:5, 1:10, 1:15, 1:25, 1:50, 1:100, 1:150) with polymer chains. Afterward, we combined GelMA Gel-Phe as an injectable photo-crosslinkable bioadhesive. This...
Adult-onset Still’s disease (AOSD) is a rare and inflammatory disorder characterized by spiking fever, rash, arthritis, multisystemic involvement. HLA has been shown to be associated with AOSD; however, it could not explain the innate immunity autoinflammatory characteristics of AOSD. To assess genetic susceptibility AOSD, we conducted genome-wide association study (GWAS) on cohort 70 AOSD cases 688 controls following replication 36 200 meta-analysis. The plasma concentrations gene product...
Summary Elm samples with and without witches’‐broom symptoms (EWB) were collected from Tai’an Zhaoyuan, Shandong Province, China. Phytoplasmal cells observed in the phloem of symptomatic plants under electron microscope. Specific fragments about 1.2 kb length amplified nested‐PCR samples, while no fragment was obtained healthy plants. The 16S rRNA gene sequences phytoplasmas associated elm (EWB‐TA) Zhaoyuan (EWB‐ZHY) had high similarities, formed a sublineage phylogenetic tree, members...
The retromolar canal is an anatomical variation that occurs in the mandibular bone. typically originates on distal side of third molar and extends forward upward to foramen (RMF), which contains neurovascular bundle. Accidentally damaging bundle during extraction molar, dental implant surgery, or maxillofacial orthognathic surgery may lead subsequent complications such as incomplete local anesthesia, paresthesia, bleeding operation. objective this study was investigate prevalence RMF...
Vincristine-induced peripheral neuropathy is a common and highly debilitating toxicity from vincristine treatment that affects quality of life often requires dose reduction, potentially affecting survival. Although previous studies demonstrated genetic factors are associated with risk, the clinical relevance most identified variants limited by small sample sizes unclear phenotypes. A genome-wide association study was conducted in 1100 cases controls matched ancestry, uncovering statistically...