A5054647809- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Tactile and Sensory Interactions
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Oral and Maxillofacial Pathology
- Music Technology and Sound Studies
- Service-Learning and Community Engagement
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Polyomavirus and related diseases
- Cardiac tumors and thrombi
- Hepatitis B Virus Studies
- Single-cell and spatial transcriptomics
- Global Education and Multiculturalism
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Peripheral Neuropathies and Disorders
- Indigenous Health, Education, and Rights
- Vascular Tumors and Angiosarcomas
- Biological Research and Disease Studies
British Columbia Children's Hospital
2024
Prince of Wales Hospital
2022
Chinese University of Hong Kong
2022
Queen Elizabeth Hospital
2012-2021
University of Manitoba
2019
University of Reading
2007
Abstract Interaction between tumor cells and immune in the microenvironment is important cancer development. Immune interact with to shape this process. Here, we use single-cell RNA sequencing analysis delineate landscape heterogeneity a cohort of patients HBV-associated human hepatocellular carcinoma (HCC). We found that tumor-associated macrophages suppress T cell infiltration TIGIT-NECTIN2 interaction regulates immunosuppressive environment. The state transition towards more exhaustive...
Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon with a deceptively bland-looking morphology that disguises its malignant clinical behavior. It shows distinctive chromosomal translocations resulting in fusion of FUS the CREB3L2 gene most cases and CREB3L1 rare cases. Thus molecular studies are particularly helpful diagnosis this sarcoma. We report 2 LGFMS serendipitously found to harbor novel alternative EWSR1-CREB3L1 fusion, as confirmed by DNA sequencing reverse...
<h3>Objective</h3> We investigated the mutational landscape of mammalian target rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, aiming to evaluate and delineate mutation-dependent mechanism mTOR hyperactivation hepatocarcinogenesis. <h3>Design</h3> performed next-generation sequencing on human HCC samples cell line panel. Systematic screening pathway-related genes was undertaken mutant were evaluated based their recurrence. Protein...
Background and Aims Hepatitis B virus (HBV) integrations are common in hepatocellular carcinoma (HCC). In particular, alterations of the telomerase reverse transcriptase ( TERT ) gene by HBV frequent; however, molecular mechanism functional consequence underlying integration unclear. Approach Results We adopted a targeted sequencing strategy to survey human HBV‐associated HCCs (n = 95). at promoter was frequent (35.8%, n 34/95) HCC tumors associated with increased mRNA expression more...
Plexiform fibromyxoma (plexiform angiomyxoid myofibroblastic tumor) is a rare benign mesenchymal tumor of stomach. The plexiform growth bland-looking spindly cells in richly vascularized fibromyxoid stroma distinctive. described cases are solid tumors associated with ulceration, the patients presenting symptoms related to ulcer or mass effect tumor. We report an unusual case as fistulating abscess. A 42-year-old woman presented abdominal pain, fever, and elevated white cell count. Computed...
Ewing sarcomas are typified by EWSR1 fusion to ETS gene family members. Tumors with partners other than members and atypical histologic features pose significant diagnostic challenges controversies as their classification. In this article, we report a tumor EWSR1-NFATC2 in the left femur of 43-year-old man unusual morphologic that resemble undifferentiated high-grade sarcoma. Analysis together reported cases literature shows tumors exhibit distinctive clinicopathologic features, including...
Reticular/microcystic schwannoma is a recently described morphologic variant of that occurs predominantly in visceral organs, most commonly the gastrointestinal tract. This report describes case occurring masticator space, accompanied by focal erosion orbital floor, clinically and radiologically worrisome for malignancy. The 26-year-old man presented with facial swelling 3 month. tumor shows multinodular appearance, dense lymphoplasmacytic infiltrates fibrous septa. nodules are composed...
Drawing on the instructor and student experiences of a service-based learning course with Indigenous peoples, this paper considers how studios develop skills competencies outlined by accrediting bodies. Yet, approach to teaching can also unsettle students’ sense professional competence faith in usefulness conventional planning methods. In case, unsettlement was valuable productive outcome that supported development more critically reflective working peoples newfound appreciation need engage...
We report an aggressive soft tissue sarcoma with FGFR1-TACC1 fusion occurring in the thigh of 83-year-old man. Microscopically, tumor was composed monomorphic spindle cells arranged intersecting fascicles. The showed ovoid nuclei, fine chromatin, indistinct nucleoli, and elongated eosinophilic cytoplasm. Focal increase nuclear atypia noted. Immunohistochemistry only focal rare positivity to S100, but negative SOX10, CD34, STAT6, TLE-1, SMA, other myogenic markers. An extensive panel...
Abstract Inspired by a type of synesthesia where colour typically induces musical notes the MusiCam project investigates this unusual condition, particularly transition from to sound. explores potential benefits idiosyncrasy as mode human computer interaction (HCI), providing host meaningful applications spanning control, communication and composition. Colour data is interpreted means an off-the-shelf webcam, music generated in real-time through regular speakers. By making colour-based...
Vincristine-induced peripheral neuropathy is a common and highly debilitating toxicity from vincristine treatment that affects quality of life often requires dose reduction, potentially affecting survival. Although previous studies demonstrated genetic factors are associated with risk, the clinical relevance most identified variants limited by small sample sizes unclear phenotypes. A genome-wide association study was conducted in 1100 cases controls matched ancestry, uncovering statistically...
Abstract We investigated the mutational landscape of mTOR signaling cascade in hepatocellular carcinomas (HCCs) with chronic hepatitis B (HBV) background, aiming to evaluate and delineate mutation-dependent mechanism hyper-activation hepatocarcinogenesis. performed next-generation sequencing on human HCC samples cell line panel. Systematic screening pathway-related genes was undertaken mutant were evaluated based their recurrence. Protein expressions TSC1, TSC2 pRPS6 assessed by...