A5100670012- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- Oral and Maxillofacial Pathology
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Peptidase Inhibition and Analysis
- Beetle Biology and Toxicology Studies
- Reconstructive Surgery and Microvascular Techniques
- Facial Trauma and Fracture Management
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Innovative Teaching Methods
- Tendon Structure and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Microbial Metabolism and Applications
- Curcumin's Biomedical Applications
- Salivary Gland Tumors Diagnosis and Treatment
Chung Shan Medical University Hospital
2021-2024
Chung Shan Medical University
2021-2024
National Taiwan University
2023
Cornell University
2018-2022
Taipei Medical University
2021
Cardinal Tien Hospital
2015-2021
Fu Jen Catholic University
2015-2021
Massachusetts General Hospital
2020
Harvard University
2020
Guangdong Food Industry Research Institute
2010
Abstract Human oral squamous cell carcinoma (OSCC) is the common head and neck malignancy in world. While surgery, radiotherapy chemotherapy are emerging as standard treatment for OSCC patients, outcome limited to recurrence side effects. Therefore, patients with require alternative strategies treatment. In this study, we aimed explore therapeutic effect mode of action novel curcumin analog, HO‐3867, against human cells. We analysed cytotoxicity HO‐3867 using MTT assay. vitro mechanic...
Abstract Oral squamous cell carcinoma (OSCC) has a high recurrence rate and poor prognosis. Hispolon, polyphenolic compound with antiviral, antioxidant, anticancer activities, is potential chemotherapy agent. However, few studies have investigated the anti‐cancer mechanism of hispolon in oral cancer. This present study used viability assay, clonogenic fluorescent nuclear staining, flow cytometry assay to analyse apoptosis‐inducing effects OSCC cells. After treatment, apoptotic initiators,...
Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with high mortality rate and heterogeneous aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), long noncoding that has been shown to act as scaffold, sponge, or signal hub promote carcinogenesis. Here, we attempted assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on susceptibility OSCC. Five SNPs, including rs564398, rs1333048, rs1537373, rs2151280 rs8181047, were...
Abstract Glioblastoma (GBM) is the most aggressive brain tumor and relapses after chemo- or radiotherapy in a short time. The anticancer drug temozolamide (TMZ) commonly used for GBM treatment, but glioma stem-like cells (GSCs) often lead to resistance therapeutic failure. To date, mechanism of GSC formation TMZ-treated remains largely unknown. CCAAT/Enhancer-binding protein delta (CEBPD) an inflammation-responsive transcription factor proposed be oncogenic context resistance, prompting us...
// Man-Hsin Hung 3, 4, 5, 6 , Cheng-Yi Wang 8 Yen-Lin Chen 9 Pei-Yi Chu 10 Yung-Jen Hsiao 1 Wei-Tien Tai 1, 2 Ting-Ting Chao Hui-Chuan Yu Chung-Wai Shiau 7 Kuen-Feng Department of Medical Research, National Taiwan University Hospital, Zhongzheng District, Center Excellence for Clinical Trial and 3 Division Oncology, Taipei Veterans General City, 4 Hematology Medicine, 5 Program in Molecular School Life Science, Yang-Ming University, Institute Biopharmaceutical Sciences, Research Center,...
Abstract Background We have previously demonstrated highly efficient baculovirus transduction of primary rat articular chondrocytes, thus implicating the possible applications in gene‐based cartilage tissue engineering. However, baculovirus‐mediated gene expression chondrocytes is transient. Methods In this study, we attempted to prolong by supertransduction, but uncovered that after long‐term culture became more refractory transduction. Therefore, correlation between enhanced green...
There is a lack of well validated prognostic biomarkers in osteosarcoma, rare, recalcitrant disease for which treatment standards have not changed over 20 years. We performed microRNA sequencing 74 frozen osteosarcoma biopsy samples, constituting the largest single center translationally analyzed cohort to date, and we separately multi-omic dataset from large NCI supported national cooperative group cohort. value candidate signatures contextualized them relevant transcriptomic epigenomic...
Visual oral examination (VOE) is a conventional cancer screening method. This study aimed to evaluate the value of methylation marker assist VOE in identifying epithelial dysplasia and squamous cell carcinoma (OED/OSCC) from non-cancerous lesions real-world situation.201 patients with high-risk personal habits who self-perceived anomaly were examined, ZNF582 (ZNF582m) tested, histologically diagnosed.Among them, 132 (65.7%) diagnosed OED/OSCC. Using VOE, 56.1% OED/OSCC had possible cancer,...
Abstract Background & Aims Few molecules are currently verified to be actionable drug targets in cholangiocarcinoma ( CCA ). Serine/threonine protein phosphatase 5 PP 5) dysregulation is related several malignancies. However, the role of poorly defined. Methods Colony and tumorsphere formation assays were conducted establish tumorigenesis. Cantharidin CTD ) norcantharidin NCTD ), both potent inhibitors, used vitro vivo experiments validate potential therapeutic 5. Results Increased cell...
Abstract Objective Whether oral lichen planus (OLP) was potentially malignant remains controversial. Here, we examined associations of ZNF582 methylation ( m ) with OLP lesions, dysplastic features and squamous cell carcinoma (OSCC). Materials Methods This is a case–control study. evaluated in both lesion adjacent normal sites 42 dysplasia, 90 OSCC 43 patients, whereas only one mucosal site 45 controls. High‐risk habits affecting such as betel nut chewing cigarette smoking were also compared...
A chemical study of the EtOAc-soluble ethanolic extract Monascus kaoliang BCRC 31506 (Eurotiaceae) fermented rice led to isolation a new furan-3-one derivative along with 9 known compounds, monascin (2), ankaflavin (3), N-trans-feruloyltyramine (4), vanillic acid (5), 4-acetonyl-3,5-dimethoxy-p-quinol ( 6), (+)-β-eudesmol (7), trans-phytol (8), aesculetin dimethyl ether 9) and (-)-matairesinol (10).Structure 1 is proposed for monascuskaoliaone on basis spectroscopic evidence (NMR, UV, IR,...
Local anesthesia (LA) training is an essential clinical skill in dental education. However, the traditional teaching method of student-to-student injection has ethical concerns. This study investigated whether a flipped classroom (FC) model with instructional videos improves students' skills administering LA. Fourth-year students 2017 (traditional teaching, n = 70) and 2018 (FC model, 79) were assessed for their ability to perform inferior alveolar nerve block lingual block. The FC group...
<title>Abstract</title> <bold>Background:</bold> Colorectal cancer (CRC) is a common and results in high mortality worldwide, owing to progression, e.g., metastasis. However, the molecular mechanism underlying metastatic evolution of CRC remains largely unknown. In this study, we investigated clinical relevance oncogenic function RGL2 CRC.<bold>Methods: </bold>Cellular migration ability was assessed by transwell cultivation. The potential estimated lung colony-forming assay. DNA-binding...
Though the gold standard method for mandible reconstruction of defect from segmental mandibulectomy is by osseous flap or graft, using plates still indicated in some cases. Traditionally, plate bended immediately after freehand. However, it's difficult to fit well original position mandible, which may result more complications. This study therefore aimed investigate whether prebent on computer-aided 3D printing models could reduce complication rate. Patients who received 2018 2022 were...
Abstract Introduction The availability of targeted and immunotherapies has provided NSCLC patients with more effective treatment options. However, this resulted in an increase the number modality tests required for selection. Given 30-50% advanced lung cancer have insufficient or unavailable tissue comprehensive genomic profiling, there is a need non-invasive assay that can accurately detect all guideline-recommended markers To meet need, we developed blood test detects six classes...
RNA triple helices are commonly observed tertiary motifs that increasingly associated with critical biological functions, including signal transduction. Because the recognition of their importance is relatively recent, full range structures and function has not yet been elucidated. The integration solution wide-angle X-ray scattering (WAXS) data-driven molecular dynamics (MD) simulations, described here, provides a new way to capture major-groove triplexes evade crystallographic...