A5102783919- Head and Neck Cancer Studies
- Abdominal Trauma and Injuries
- Semiconductor materials and devices
- Lung Cancer Treatments and Mutations
- Abdominal vascular conditions and treatments
- Trauma and Emergency Care Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral Health Pathology and Treatment
- Advanced Memory and Neural Computing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Dental Implant Techniques and Outcomes
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Ferroelectric and Negative Capacitance Devices
- Innovative Teaching and Learning Methods
- Nasolacrimal Duct Obstruction Treatments
- Spinal Hematomas and Complications
- Nanowire Synthesis and Applications
- Gallbladder and Bile Duct Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Glutathione Transferases and Polymorphisms
- Telomeres, Telomerase, and Senescence
- Oral health in cancer treatment
Taipei Veterans General Hospital
2010-2024
National Yang Ming Chiao Tung University
2004-2022
National Taipei University
2004-2022
Second Affiliated Hospital of Zhejiang University
2021
Chang Gung University
2012-2020
Chang Gung Memorial Hospital
2012-2020
Shanghai Pulmonary Hospital
2019
National Sun Yat-sen University
2017-2018
Linkou Chang Gung Memorial Hospital
2017
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016
Oral squamous cell carcinoma (OSCC) is one of the most prevalent carcinomas worldwide. MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and modulate physiological or pathological processes including OSCC carcinogenesis. miR-31 has been found to be up-regulated in act as an oncogenic miRNA. However, molecular mechanism underlying up-regulation still obscure. The activation epidermal growth factor receptor (EGFR) signaling axis plays key roles driving oral Our...
Perineural invasion is a pathological feature that may affect cancer cell progression and thus can result in prognostic impacts, especially oral squamous carcinoma (OSCC). However, factors regulating perineural during OSCC remain obscure.Expression of miR-21 phosphatase tensin homolog was checked surgical specimens from cases OSCC. The results were analyzed for histopathologic factors, including clinical prognosis.One-hundred patients enrolled this study. High expression related to worse...
In this paper, we discover an operation method that can effectively decrease the forming voltage in resistance random access memory (RRAM). Forming be reduced by either increasing rising time of forming-waveform or temperature process. However, resulting electronic RRAM characteristics after each these methods differ. While causes greater damage to switching layer due longer accumulation charge, process does not. The high temperature-formed excels retention and endurance tests, proving...
Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into mechanisms underlying this drug is great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involved both innate acquired cisplatin resistance. We demonstrated that p62-mTORC1 signaling complex plays pivotal role, driven by EGFR network, specifically through PI3K-Akt axis transcription factor C/EBP-β. Elevated...
Human tumorous imaginal disc (Tid1), a DnaJ co-chaperone protein, is classified as tumor suppressor.Previously, we demonstrated that Tid1 reduces head and neck squamous cell carcinoma (HNSCC) malignancy.However, the molecular details of Tid1-mediated anti-metastasis remain elusive.Methods: We used affinity chromatography systemic mass spectrometry to identify Tid1-interacting client proteins.Immunohistochemical staining in HNSCC patient tissues was examined evaluate association between...
Abstract Background To explore the clinicopathological significance of tumor budding (TB) on oral squamous cell carcinoma (OSCC) prognosis. Methods Data 200 patients with OSCC were retrieved from cancer registration database in Taipei Veterans General Hospital. Clinicopathological characteristics and survival relevant to TB analyzed. Results The data showed that was predominant tongue floor mouth younger correlated several pathological factors, such as perineural invasion lymphovascular...
Abstract Background: The importance of the CYP1A1 polymorphisms at exon 7 (Ile/Val) and 3′‐untranslated region (3′‐UTR) has been controversial in oral squamous cell carcinoma (OSCC) or head neck SCC (HNSCC) denoting value exploring correlation between these risk betel/smoking associated OSCC. It is also important to evaluate association susceptibility precancerous lesion (OPL) confirm findings OSCC cases. Methods: We examined polymorphic prevalence 3′‐UTR 106 cases with OSCC, 60 OPL, 146...
Background: Circulating matrix metalloproteinase‐9 (MMP‐9) is a prognostic factor for gastric cancer and vascular diseases, has been associated with head neck cancers. The − 1562 C‐to‐T polymorphism in MMP‐9 promoter (abbreviated C>T polymorphism) leads to differential transcription, increased susceptibility neoplastic diseases. Thus, our aim was determine whether functional might also influence the risk or affect progression of areca‐associated oral Methods: Genomic DNAs were obtained...
Objective: Clinical presentation and physical signs may be unreliable in the diagnosis of stercoral colitis (SC).This study evaluates value computed tomography (CT) distinguishing fatal from non-fatal SC. Materials Methods: Ten patients diagnosed as SC were obtained inter-specialist conferences.Additional 13 with suspected identified via Radiology Information System (RIS).These divided into two groups; SCs.Their CT images are reviewed by board-certified radiologists blinded to clinical data...
In this study, the rising forming voltage issue during device cell scale‐down in resistance random access memory (RRAM) is solved by introducing new high‐permittivity (high‐ k ) material as side‐wall spacer structure, unlike normally used low‐permittivity (low‐ material. Simulated electrical fields based on COMSOL Multiphysics software results suggest a RRAM with high‐ effectively confines electric field. The effects of confined field are notable, especially when scaled down. fabrication...
Endoplasmic reticulum (ER) stress response is an adaptive program to cope with cellular that disturbs the function and homeostasis of ER, which commonly occurs during cancer progression late stage. Late-stage cancers, mostly requiring chemotherapy, often develop treatment resistance. Chemoresistance has been linked ER response; however, most evidence come from studies correlate expression markers poor prognosis or demonstrate proapoptosis by knockdown stress-responsive genes. Since in...
Oral squamous cell carcinoma (OSCC) is one of the most commonly diagnosed cancers worldwide. Chromosome 20q a hotspot for gene amplification in OSCC and serine/threonine kinase STK15 (also named Aurora-A) maps to 20q13. The over-expression common neoplasia but functional clinical impact remains poorly understood. copy number amplified 12% OSCCs nuclear protein expression increases with tumour progression. In vivo elevated significantly associated worse prognosis patients. combination high...
Recurrent/ metastatic squamous cell carcinoma of head and neck (R/M SCCNH) is still a difficult-to-treat disease with poor clinical outcomes limited treatment choices. In view locoregional recurrent versus distant SCCHN, the therapeutic efficacy cetuximab-containing regimen relevant prognostic factors for these two groups may be different. Thus, aim this study was to explore in SCCHN groups, identify correlated better survival outcomes.From 2016 2020, patients R/M who received our institute...
Lattice-matched In0.48Al0.52P was grown on a p-type Ge(100) substrate by metal-organic chemical vapor deposition, and the band-alignment of Ge obtained high resolution x-ray photoelectron spectroscopy. The valence band offset for InAlP/Ge(100) interface found to be 0.86 eV, with corresponding conduction 0.84 eV. From values obtained, energy diagram InAlP/Ge is type I.
Oral squamous cell carcinoma (OSCC) leads to thousands of deaths every year in Taiwan. Nearly 40% OSCC patients are diagnosed with stage IV disease, which has a poor prognosis. Multimodality treatments including surgery and adjuvant therapy have been utilized, but their treatment outcomes generally poor. In this study, we sought identify possible clinical impact factors that may contribute the survival OSCC.Data for malignant neoplasms oral cavity registered Cancer Registry Database Taipei...
Visual oral examination (VOE) is a conventional cancer screening method. This study aimed to evaluate the value of methylation marker assist VOE in identifying epithelial dysplasia and squamous cell carcinoma (OED/OSCC) from non-cancerous lesions real-world situation.201 patients with high-risk personal habits who self-perceived anomaly were examined, ZNF582 (ZNF582m) tested, histologically diagnosed.Among them, 132 (65.7%) diagnosed OED/OSCC. Using VOE, 56.1% OED/OSCC had possible cancer,...
Twelve patients presented with oral submucosal fibrosis and loss of keratinized gingiva in a compromised vestibule severely deficient mandibular edentulous ridge secondary to cancer surgery. They received implant rehabilitation total 49 fixtures without major bone graft augmentation. To overcome vestibular compromise, soft tissue management consisting simultaneous vestibulo-sulcoplasty, split-thickness skin (STSG), palatal mucosa (KMG) was performed as second stage when healing abutment...
To evaluate the failure pattern and identify predictors of locoregional control in lateralized buccogingival cancer after postoperative radiotherapy (RT) at a single institution.We retrospectively reviewed clinical data 150 patients with oral squamous cell carcinoma, including carcinoma buccal mucosa, gingiva retromolar trigone. All underwent radical surgery followed by RT or without concurrent chemotherapy. We registered planning computer tomography images obtained recurrence categorized as...