A5102997713- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Renal Transplantation Outcomes and Treatments
- PARP inhibition in cancer therapy
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects and Toxicity Studies
- Beetle Biology and Toxicology Studies
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Marine Sponges and Natural Products
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- HIV/AIDS drug development and treatment
- Cancer-related gene regulation
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Peptidase Inhibition and Analysis
- Advancements in Transdermal Drug Delivery
Lishui Central Hospital
2018-2024
Cheng Ching Hospital
2017-2024
Guangdong Medical College
2013-2024
National Taiwan University Hospital
2024
Ningbo University
2022-2023
Medical Research Foundation
2023
Weatherford College
2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023
Ningbo Medical Center Lihuili Hospital
2019-2023
First People's Hospital of Foshan
2023
Praeruptorin A (PA) is a pyranocumarin present in the dried root of Peucedanumpraeruptorum Dunn that has anticancer effects against several types cells. However, effect PA on human cervical cancer cells unknown. Our results indicate significantly inhibited cell proliferation, colony formation, migration, invasion, and wound closure HeLa SiHa cells, induced cycle arrest at G0/G1 phase, upregulated Rb, p16, p21 p27 proteins downregulated cyclin D1 S-phase kinase-associated protein 2 (Skp2)...
Nasopharayngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)‐associated malignancy. It known that microRNAs are implicated in the progression of NPC. However, role miR‐204 NPC poorly understood. In this study, we found was down‐regulated cells and tissues. Low‐level expression significantly associated with a more aggressive poor prognostic phenotype We further EBV‐encoded latent membrane protein 1 (LMP‐1) suppressed by activating Stat‐3. Cdc42 identified as direct target miR‐204. Mir‐204...
MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and commonly downregulated in multiple cancers. But expression function hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated relationship between endogenous HCC progression explored regulatory mechanism HCC. We found that decreased tissues cells. Lentivirus-mediated overexpression inhibited cell proliferation induced apoptosis. Bioinformatics analysis luciferase assay identified as...
Abstract Licochalcone A (LicA), a natural compound extracted from licorice root, has been shown to exert variety of anticancer activities. Whether LicA such effects on endometrial cancer (EMC) is unclear. This study aims investigate the antitumor EMC. Our results show that significantly reduced viability and induced apoptosis EMC cells EMC‐7 patients. was also found induce endoplasmic reticulum (ER) stress, leading increased expression ER‐related proteins (GRP78/PERK/IRE1α/CHOP) in cell...
Acne is a chronic inflammatory skin disease that often occurs with anaerobic Propionibacterium acnes (P. acnes). Anti-acne patches, made of hydrocolloid or hydrogel, have become popular way topical treatment. The outer water-impermeable layer commercial patches might create hypoxic conditions and promote P. growth. In this study, gelatin/chitosan (GC) bilayer were prepared at different temperatures included room temperature (RT), −20 °C/RT, −80 °C/RT. most promising GC patch (−80 °C /RT)...
To improve the clinical outcome of tumor chemotherapy, more effective combination treatments against metastasis and recurrence are required. Licochalcone A (LicA) is root Glycyrrhiza inflata has been reported to possess anti-inflammatory, antimicrobial, antitumor effects. Sorafenib (Sor), a multikinase inhibitor, used treat patients with solid tumors such as advanced hepatocellular carcinoma (HCC). However, synergistic effects LicA Sor on human HCC cells have not reported. We found that did...
Annexin A2 has been involved in cancer cell adhesion, invasion and metastasis. However, the exact function mechanism of tumor progression NSCLCs have not elucidated. In this study, we showed that was evidently overexpressed human lines tissues. Clinicopathologic analysis expression significantly correlated with clinical stage, lymph node Kaplan-Meier revealed patients high had poorer overall survival rates than those low expression. Moreover, found knockdown suppressed proliferation cells....
Aims: Metastasis-associated gene 2 ( MTA2 ) is reported to play an important role in tumor progression, but little known about the of nasopharyngeal carcinoma (NPC). The aim study was explore expression and function NPC. Methods: Expression NPC tissues cell lines detected by immunohistochemistry Western blotting. Relationship between clinicopathological features analyzed. Stable MTA2-overexpressing MTA2-siliencing cells were established transfection with plasmids encoding cDNA...
Hydroquinone (HQ), a metabolite of benzene, is well‐known human carcinogen; however, its molecular mechanisms action remain unclear. MeCP2 has been traditionally described as transcriptional repressor, though growing evidence indicates that it also activates gene expression. Here, we investigated whether some epigenetic machinery genes are aberrantly expressed target tumor suppressor in HQ‐transformed TK6 lymphoblastoid cells. Our results showed treatment with 5‐Aza‐2′‐deoxycytidine or...
Purpose: MicroRNAs (miRNAs) play important roles in tumorigenesis and metastasis by regulating genes expression. MiRNA-148b (miR-148b) had been reported to inhibit tumor progression some kinds of cancers, but the functions miR-148b nasopharyngeal carcinoma (NPC) remain largely unknown. The aim this study was investigate functional role NPC. Methods: Expression NPC tissues cell lines detected quantitative reverse transcription polymerase chain reaction. MiR-148b overexpressed CNE2 C666-1...
Previous studies reported that norcantharidin (NCTD) has anti-tumor effects. We investigated the antitumor effects and underlying mechanism of NCTD on human renal cancer in vitro vivo. significantly decreased cell viability by induction apoptosis, as determined MTT assay annexin V/PI staining. treatment 786-O A-498 cells altered expression caspase family proteins PARP. Moreover, induced mitochondrial depolarization, which was accompanied an increased level Bax levels Bcl-2 Mcl-1. endoplasmic...
Pregnancy zone protein (PZP), a member of the proteinase inhibitor I39 (-2-macroglobulin) family proteins, is involved in initiation and development various tumors. The gene encoding PZP hypermethylated expressed at low levels hepatocellular carcinoma (HCC) tissue cells, but function HCC cells remains unclear. Here, we analyzed DNA methylation mRNA expression Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset. We identified 10 methylation-driven genes, which was significantly poorly...
Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial. The methylation alterations of other regions within are still rarely researched. present study aimed to explore the changes body CRC and find whether they were associated with staging CRC.Paired tissues corresponding adjacent normal from 30 patients collected. levels two CpG islands body, exon 1 2, accurately assessed...