A5046805224- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Inflammatory mediators and NSAID effects
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Synthesis and Biological Evaluation
- Geophysics and Gravity Measurements
- Ionosphere and magnetosphere dynamics
- Synthesis and biological activity
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- biodegradable polymer synthesis and properties
- Laser Applications in Dentistry and Medicine
- Medicinal Plants and Neuroprotection
- Influenza Virus Research Studies
- Estrogen and related hormone effects
- Protein Kinase Regulation and GTPase Signaling
- Parasite Biology and Host Interactions
- NF-κB Signaling Pathways
- 3D Printing in Biomedical Research
- GNSS positioning and interference
- Angiogenesis and VEGF in Cancer
Central Taiwan University of Science and Technology
2009-2023
China Medical University
2023
China Medical University Hospital
2023
China Medical University
2023
Asia University
2023
National Taiwan University
2007-2010
Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated CA extract facilitates the wound-repair process by promoting fibroblast proliferation and collagen synthesis exhibits antibacterial activity. Gelatin nanofibres containing C. were fabricated via electrospinning exhibit dermal wound-healing activity in rat model. The areas of skin treated with electrospun gelatin membranes (EGC) presented...
Impaired growth factor production, angiogenic response, macrophage function, and collagen accumulation have been shown to delay wound healing. Delayed healing is a debilitating complication of diabetes that leads significant morbidity. In this study, curcumin Lithospermi radix (LR) extract, which are used in traditional Chinese herbal medicine, were added within nanofibrous membranes improve streptozotocin (STZ)-induced diabetic rat model. Gelatin-based nanofibers, constructed with LR...
In this study, magnetic nanoparticles composed of a core (doxorubicin–gelatin) and shell layer (Fe3O4–alginate) were developed to function as targeted anticancer drug delivery vehicles. The doxorubicin (DOX) was selected model embedded in the inner gelatin obtain high encapsulation efficiency. advantage outer is that it targets tumor tissue provides controlled release. physicochemical properties doxorubicin–gelatin/Fe3O4–alginate (DG/FA NPs) characterized using scanning electron microscopy,...
A novel series of topoisomerase I (Top I) inhibitors were designed on the basis camptothecin using scaffold modification strategy. Thirty-one new compounds synthesized and evaluated for anticell proliferation activity. The most potent compound 26 presented a significant inhibitory effect Top I, leading to I-mediated cleavage influences expression at cellular level. Moreover, was proved induce cell death via apoptosis accelerated DNA strand breaks without alteration in cycle populations. All...
Acne is a chronic inflammatory skin disease that often occurs with anaerobic Propionibacterium acnes (P. acnes). Anti-acne patches, made of hydrocolloid or hydrogel, have become popular way topical treatment. The outer water-impermeable layer commercial patches might create hypoxic conditions and promote P. growth. In this study, gelatin/chitosan (GC) bilayer were prepared at different temperatures included room temperature (RT), −20 °C/RT, −80 °C/RT. most promising GC patch (−80 °C /RT)...
Three-dimensional (3D) cell culture enhanced cells-cells communication, promoting developmental processes and influencing performance. In this study, 3D alginate-gelatin core–shell capsules (AGC) were fabricated by using a microfluidic device. Human osteoblast-like MG-63 cells encapsulated within the model. The morphology physicochemical properties of AGC characterized scanning electron microscopy (SEM), Flourier Transform Infrared Spectrum (FTIR), Gravimetric thermal analyzer (TGA). mRNA...
Until recently, all seasonal influenza vaccines have been trivalent, containing strains A(H1N1), A(H3N2), and one of the two B strain lineages (Yamagata or Victoria), resulting in frequent mismatches between circulating lineage that included vaccine. A quadrivalent, inactivated, split-virion vaccine (IIV4) from both has developed to address this. We performed an open-label phase III study assess immunogenicity safety 2013–2014 Northern Hemisphere formulation IIV4 children adolescents 9–17...
Tricalcium phosphate (TCP) has gained attention due to its interconnected porous structures which promote fibrovascular invasion and bony replacement. Moreover, when gelatin is added crosslinked with genipin (GGT), TCP exhibits robust biocompatibility stability, making it an excellent bone substitute. In this study, we incorporated emodin lumbrokinase (LK) into GGT develop antibacterial biomaterial. Emodin, derived from various plants, possesses anti-inflammatory properties. LK comprises...
Abstract Background Wound healing is a highly complex and intricate biological process involving cellular molecular events. This study aims to investigate the potential of gelatin nanofibers containing lumbrokinase (LK), fibrinolytic enzyme derived from earthworms, fabricated through electrospinning as novel therapeutic strategy for promoting wound healing. Methods determined therapeutical concentration (LK) in vitro cell proliferation assay, angiogenesis, anti-inflammation assay. In...