Renal cell carcinoma (RCC) is the most lethal of all urological malignancies because its potent metastasis potential. Melatonin exerts multiple tumor-suppressing activities through antiproliferative, proapoptotic, and anti-angiogenic actions has been tested in clinical trials. However, antimetastastic effect melatonin underlying mechanism RCC are unclear. In this study, we demonstrated that at pharmacologic concentration (0.5-2 mm) considerably reduced migration invasion cells (Caki-1 Achn)....

Abstract The matrix metalloprotease A disintegrin and with thrombospondin motifs 1 (ADAMTS1) was reported to be involved in tumor progression several cancer types, but its contributions appear discrepant. At present, the role of ADAMTS1 oral squamous cell carcinoma (SCC; OSCC) remains unclear. Herein, Cancer Genome Atlas (TCGA) database showed that transcripts were downregulated head neck SCC (HNSCC) tissues compared normal tissues, levels correlated poorer prognoses HNSCC patients. In...

Abstract The intricate involvement of the histaminergic system, encompassing histamine and receptors, in progression diverse neoplasias has attracted considerable scrutiny. Histamine receptor H1 (HRH1) was reported to be overexpressed several cancer types, but its specific functional implications oral squamous cell carcinoma (OSCC) predominantly remain unexplored. Our findings indicate that dysregulated high levels HRH1 were correlated with lymph node (LN) metastasis poor prognoses OSCC...

A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) family are widely implicated in tissue remodeling events manifested cancer development. ADAMTS1, the most fully characterized ADAMTS, plays conflicting roles different types; however, role of ADAMTS1 renal cell carcinoma (RCC) remains unclear. Herein, we found that is highly expressed RCC tissues compared to normal tissues, its expression was correlated an advanced stage a poor prognosis patients. In vitro, observed higher...

Renal cell carcinoma (RCC) is one of the most lethal genitourinary malignancies with poor prognoses, since it largely resistant to chemotherapy, radiotherapy, and targeted therapy. The persistence cancer stem cells (CSCs) major cause treatment failure RCC. Recent evidence showed that dopamine receptor D2 (DRD2)-targeting antipsychotic drugs such as penfluridol exert oncostatic effects on several types, but effect RCC remains unknown. Here, we uncovered suppressed in vitro growth vivo...

Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) has been reported to play an oncogenic role in certain cancer types; however, the of SPOCK1 progression clear cell renal carcinoma (ccRCC) remains elusive. Here, higher transcript protein levels were observed ccRCC tissues compared normal correlated with advanced clinical stages, larger tumor sizes, lymph node distal metastases. Knockdown overexpression cells led decreased increased clonogenic migratory/invasive...

Abstract Although new generations of EGFR-tyrosine kinase inhibitors (EGFR-TKI) have been developed for the treatment patients with non–small cell lung cancer (NSCLC) EGFR-mutant tumors, TKI resistance often returns as a result additional EGFR mutations. In addition to seeking next-generation EGFR-TKI, developing novel EGFR-targeting strategies may hold key overcome vicious cycle resistance. Endocan is known receptor tyrosine ligand enhancer in tumorigenesis, but impact endocan on...

KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the of KSRP clear cell renal carcinoma (ccRCC) remains poorly understood.KSRP expression was detected by ccRCC tissue microarray evaluated an silico analysis. Cell loss-of-function gain-of-function, colony-formation, anoikis, transwell assays, orthotopic...

Non-small-cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and adenocarcinoma (LUAD) the most common pathological subtype. Epidermal growth factor (EGF) receptor (EGFR) mutations are driver of LUAD, they have been identified as important therapeutic targets by EGFR-tyrosine kinase inhibitors (TKIs). The proinflammatory cytokine, interleukin (IL)-17A, IL-17A-producing cells were reported to be elevated in tumor microenvironment peripheral blood NSCLC patients correlated...

Hepatocellular carcinoma (HCC) is one of the most common malignancies in world, especially, eastern Asia, and its prognosis poor once metastasis occurs. Niclosamide, a US Food Drug Administration-approved antihelmintic drug, was shown to inhibit growth various cancers including HCC, but effect niclosamide on cell motility underlying mechanism have not yet been completely defined. The present study demonstrated that niclosamide, at 0-40 nM, concentration-dependently inhibited wound closure...

Oral squamous cell carcinoma (OSCC) is the most frequently encountered type of oral cancer. Histamine receptor H1 (HRH1) was reported to play a crucial role in OSCC carcinogenesis, but impacts genetic variants HRH1 on remain unclear. Herein, we investigated association between functional single-nucleotide polymorphisms (SNPs) and susceptibility or clinicopathologic variables by logistic regression models. genotypes at four loci (rs346074, rs346076, rs901865, rs2606731) were analyzed TaqMan...

Long noncoding (lnc)RNAs are reported to be key regulators of tumor progression, including hepatocellular carcinoma (HCC). The lncRNA long intergenic RNA 00673 (LINC00673) was indicated play an important role in HCC but the impacts genetic variants (single-nucleotide polymorphisms, SNPs) LINC00673 on remain unclear. A TaqMan allelic discrimination assay performed analyze genotypes three tagging SNPs, viz., rs9914618 G > A, rs6501551 G, and rs11655237 C T, 783 patients 1197 healthy subjects....

Abstract Objective To examine how mental health interplays with menopausal status in relation to sleep patterns and rest-activity rhythms (RARs) among middle-aged women. Methods This cross-sectional study recruited 87 women aged 45 60 years from community a gynecology clinic Taiwan. Participants wore actigraphy devices for 7 days were also assessed self-reported questionnaires. Hierarchical regression was used the effects of on RARs. Results Perimenopausal postmenopausal had higher relative...

Abstract N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles Naa10p were reported in cancers. Here, we report an oncogenic role promoting metastasis osteosarcomas. Higher NAA10 transcripts observed metastatic osteosarcoma tissues compared to non-metastatic and also correlated with a worse prognosis patients. Knockdown overexpression cells respectively led decreased increased cell migratory/invasive abilities....

Background Solid tumor cells encounter stress from oxygen and glucose limitation as tumors continue to grow. This kind of metabolic in the solid interiors affects cancer stem cell (CSC) formation. However, mechanisms how are affected by glucose, a key nutrient microenvironment, exist many controversial reports it still remain largely elusive. Design The enhancement population were detecting ability sphere formation, percentage CD133 + positive cells, expression markers under condition. We...

Purpose Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related deaths in world. Due to difficulty early diagnosis and treatment HCC, prognosis for patients remains poor past decade. Therefore, our aim this study establish screening model discover novel diagnostic prognostic markers HCC patients. Design Systemic analysis global gene expressions by using Mass Spectrometry an attractive approach identify biomarkers development therapeutics diagnostics. In study, fresh...

<p>SUPPLEMENTARY INFORMATION Supplementary material and methods, Table S1, Figure S1-S7 - This file contains methods; S1. The Cox univariate multivariate analyses of endocan clinicopathological factors in overall survival patients NSCLC patients.; clinical value lung adenocarcinoma.; S2. Correlation EGFR expression cancer S3. Endocan enhances EGF�induced activation a concentration-dependent manner.; S4. JAK/STAT3 ERK/ELK signaling regulates promoter activity.; S5. interaction...

<p>SUPPLEMENTARY INFORMATION Supplementary material and methods, Table S1, Figure S1-S7 - This file contains methods; S1. The Cox univariate multivariate analyses of endocan clinicopathological factors in overall survival patients NSCLC patients.; clinical value lung adenocarcinoma.; S2. Correlation EGFR expression cancer S3. Endocan enhances EGF�induced activation a concentration-dependent manner.; S4. JAK/STAT3 ERK/ELK signaling regulates promoter activity.; S5. interaction...