A5019339525- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Luminescence Properties of Advanced Materials
- Ultrasound and Hyperthermia Applications
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- RNA modifications and cancer
- Ultrasound and Cavitation Phenomena
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Iron oxide chemistry and applications
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Photodynamic Therapy Research Studies
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Quantum Dots Synthesis And Properties
- Advanced Photocatalysis Techniques
- Cancer Immunotherapy and Biomarkers
National Yang Ming University Hospital
2025
National Yang Ming Chiao Tung University
2023-2025
National Taiwan University
2016-2023
Genomics Research Center, Academia Sinica
2019-2023
Academia Sinica
2019-2022
National Health Research Institutes
2022
National Cheng Kung University
2022
Kaohsiung Veterans General Hospital
2022
Bridge University
2022
Taipei Medical University
2022
Photodynamic therapy (PDT) based on photosensitizers (PSs) constructed with nanomaterials has become popular in cancer treatment, especially oral carcinoma cell. This is characterized by improved PS accumulation tumor regions and generation of reactive oxygen species (ROS) for PDT under specific excitation. In the selection near‐infrared (NIR) window, 808 nm NIR light because it can avoid absorption water particularly suitable application PDT. Hence, multiband emissions a single excitation...
Abstract The importance and practicality of near‐infrared (NIR) light for the biomedical field has attached to academe industry with development technology. Luminescent materials different doping strategies are promising candidates covering biological windows from 700 nm 1 nm. relationship between NIR light, nanophosphors, tissue towards function diagnostic therapy in is explored clearly, which corresponds diffuse reflection spectroscopy bioimaging light‐emitting diode (LED)...
Abstract In the biomedical field, use of fluorescence imaging in second near‐infrared (NIR‐II) region is growing rapidly because it imparts advantages reduced autofluorescence and low photon scattering. The advantage scattering that increases penetration depth vivo improves clarity. Herein, this work uses mesoporous silica, a biocompatible template can be easily modified, functionalized, loaded with drugs for several bioapplications. ZnGa 2 O 4 spinel oxide system integrated into silica...
Photoluminescent materials (PLNs) are photoluminescent that can absorb external excitation light, store it, and slowly release it in the form of light dark to achieve long-term luminescence. Developing near-infrared (NIR) PLNs is critical improving long-afterglow luminescent materials. Because they excite vitro, NIR-PLNs have potential avoid interference from vivo autofluorescence biomedical applications. These promising for biosensing bioimaging applications by exploiting biological window....
Background Cholangiocarcinoma is a challenging malignancy with limited responses to conventional therapies, particularly immune checkpoint inhibitor therapy. Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are key components of the tumor microenvironment (TME) have been implicated in response cancer. However, role difference TLSs TILs patients cholangiocarcinoma remains unclear. This study elucidates their contributions TME. Methods We examined 16 samples from...
Light therapy has become the subject of research on cancer treatment because its selectivity, low invasive damage, and side effects. Photothermal (PTT) photodynamic (PDT) are prevalent treatments used to induce cell apoptosis by generating heat reactive oxygen species (ROS). In this study, mesoporous silica shell-coated gold nanorods (AuNR@mS) synthesized seed crystal growth method. AuNR@mS assembled into nanocomposites through electrostatic adsorption with lanthanide-doped upconversion...
Photodynamic therapy (PDT) is a promising antitumor treatment that based on photosensitizers. This kills cancer cells by generating reactive oxygen species (ROS) after irradiation with specific laser wavelengths. Being potential photosensitizer, graphitic carbon nitride (g-C3N4) quantum dots (QDs) are noncytotoxic. Although the use of g-C3N4 QDs challenged limited tissue penetration UV light, display excellent ultraviolet (UV) light-triggered cytotoxicity. The were synthesized using...
Glioblastoma (GBM) is one of the deadliest and most invasive brain cancers/gliomas, there currently no established way to treat this disease. The treatment GBM typically involves intracranial surgery followed by chemotherapy. However, blood–brain barrier (BBB) impedes delivery chemotherapeutic drug, making challenging. In study, we embedded a drug other nanomaterials into nanobubble (NB), utilized active tracking guidance mechanisms guide nanocomposite tumor site, then used high-intensity...
The rate of lung cancer has gradually increased in recent years, with an average annual increase 15%. Afatinib (AFT) plays a key role preventing non-small cell carcinoma (NSCLC) growth and spread. To the efficiency drug loading NSCLC tracking, near infrared-persistent luminescence nanomaterials (NIR PLNs), silica shell-assisted synthetic route for mono-dispersal, are developed used nanovehicle. After optimizing their physical chemical properties, NIR PLNs able to absorb light energy emit...
The size range of an atom is approximately 3–5 Å (10−10 m), while a nanometer 10−9 m. Thus, nanomaterials are used as multipliers that can be to attach several single atoms the surface. It similar exquisitely-arranged production line, with every acting operator, working on each catalytic reaction. As applied biological applications, these targets become proteins in vivo, and transformation into single-atom enzymes illustrates potential new nanozyme (SAN) nanotechnology for applications. SAN...
Upconversion nanocomposites embedded in nanobubbles can be a new technique to achieve imaging and therapy under 808 nm irradiation.
Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent novel treatment by using an NB-encapsulated hybrid nanosystem that can be monitored US fluorescent imaging activated near-infrared (NIR) light. The was transported to the tumor through enhanced permeability retention effect. comprised upconversion nanoparticle (UCNP) mesoporous silica-coated gold nanorod...
Abstract Light‐harvesting and conversion ability is important to promote plant growth, especially when resources are limited. A near‐infrared (NIR) nanophosphor embedded with mesoporous silica nanoparticles (MSN), ZnGa 2 O 4 :Cr 3+ ,Sn 4+ (ZGOCS), was developed its optical properties were harnessed enhance the photosynthetic of Brassica rapa spp. chinensis . The broad excitation ZGOCS from ultraviolet visible region allowed extra light into (650–800 nm) thus promoted dual photosystem via...
Metabolic reprogramming and elevated glycolysis levels are associated with tumor progression. However, despite cancer cells selectively inhibiting or expressing certain metabolic enzymes, it is unclear whether differences in gene profiles influence patient outcomes. Therefore, identifying the enzyme action may facilitate discovery of ontology variations to characterize tumors. Fructose-1,6-bisphosphate (F-1,6-BP) an important intermediate glucose metabolism, particularly cancer....
Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC basic MRI difficult, then doctors use T1-weighted or T2-weighted with contrast agent has long-term retention in the liver, such as Fe3O4 FePt, to aid diagnosis. One challenging goal prevention developing method further treat inhibit cells at time Functionalized porous kaolinite serve not only drug delivery system for treating but also scaffold carry...
Glioblastoma (GBM) is a fatal cancer. Existing therapies do not have significant efficacy for GBM patients. Previous studies shown that the collagen family involved in regulation of extracellular environment cancer cells, and these conditions could become an important factor effective treatment. Therefore, we screened various types observed type V α1 chain (COL5A1) gene plays pivotal role GBM. We further examined whether overexpression COL5A1 common mesenchymal subtypes related to survival...