Human cervical cancer is the fourth most common malignancy among women worldwide, and it expected to result in 460,000 deaths per year by 2040. Moreover, patients with often display drug resistance severe side effects; therefore, development of effective novel chemotherapeutic agents important. In present study, effects metformin, a first‑line therapeutic for type 2 diabetes mellitus, were evaluated cancer. Compared control group, metformin significantly inhibited cell viability migration,...

Cervical cancer is the fourth most frequent malignancy in women. Apigenin a natural plant-derived flavonoid present common fruit, vegetables, and herbs, has been found to possess antioxidant anti-inflammatory properties as health-promoting agent. It also exhibits important anticancer effects various cancers, but its are not widely accepted by clinical practitioners. The study investigated molecular mechanisms of apigenin cervical vitro vivo. HeLa C33A cells were treated with different...

To assess the possible correlations between reported candidate genes (VEGFR3, FOXC2, ITGA9 and ITGB1) clinical response in fetuses with severe congenital chylothorax (CC) treated by prenatal OK-432 pleurodesis.We studied 12 unrelated CC, receiving fetal therapy pleurodesis. Genotyping of parameters these were investigated. Additional 96 control individuals enrolled to evaluate polymorphisms at population.A recurrent heterozygous missense mutation (c.1210G>A, p.G404S) was identified...

Women of reproductive age are at risk ruptured corpus luteum with hemoperitoneum. We identified the clinical and demographic features patients recently treated in our institution compared findings those from an earlier series, to detect any changes disease identity that have occurred over past 20 years.Charts between January 2001 December 2003 Changhua Christian Hospital were reviewed. Clinical parameters previous study 1980s.A total 91 women diagnosed hemoperitoneum (mean age, 26 years;...

Cervical cancer is globally the fourth most common in women. Metformin a widely used drug for treatment of type II diabetes and has been shown to possess important anticancer properties cervical cancer. Everolimus an mTOR inhibitor treat NETs, RCC, TSC, breast cancers. The present study investigated effects metformin everolimus cancer, when alone or combination. CaSki C33A human cells were treated with different concentrations combination metformin. Cell viability was assessed using CCK-8...

Accurate diagnostic assessment of human epidermal growth factor receptor-2 (HER-2) is essential and a prerequisite for appropriate application the humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin) to treatment patients with breast cancer. Immunohistochemistry (IHC) most widely applicable modality in studying HER-2 status. Fluorescence situ hybridization (FISH) also recognized as cases an equivocal IHC status (score, 2+). Some authors claimed that FISH alone sufficient. The aim...

We report our experience of late feticide in Taiwan as well a novel technique, fetal cardiac tamponade, which can be used the termination pregnancy. Twenty-six patients who elected to undergo were enrolled this study (among 40 pregnancies with abnormalities diagnosed gestation during 2005–2008 tertiary referral center Taiwan). The these included structural malformations and/or genetic defects. This conformed strictly regulation law and was approved by Institutional Review Board/Ethics...

To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients International Federation of Gynecology Obstetrics papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 2012 were analyzed for clinical pathological factors relation to prognosis. A total 267 (stage IA; n = 175, IB; 92) included. Among features, age significant prognostic factors. The recurrence rate overall survival IB versus...

Mature cystic teratoma is a common benign ovarian tumor. But extragonadal teratomas are very rare. They mainly occur in the midline structure of body. Uterine extremely rare with only few reports. The diagnosis was based on operative findings. We report case uterine mature 37 year-old woman who diagnosed before operation. also review literature about this exceptional presentation. that initially as tumor under ultrasound examination. highly suspected preoperatively by abdominal CT scan. She...

Abstract Circulating tumor cell (CTC) is commonly used as biomarker for early detection, prognostication, decision making, and evaluation of the therapeutic efficacy in cancer treatment. Unfortunately, poor reproducibility limited sensitivity with CTC detection have its potential impact on clinical management. A reliable automated system therefore needed. We designed an microfluidic chip-based consisting three main parts: V-BioChip, Cell RevealTM enrichment staining system, automatic...

Improvements in equipment and diagnostic skills mean that more abnormalities can now be detected antenatally, thus increasing the demand for pregnancy termination at later stages of gestation. Potassium chloride injected into fetal circulation is most frequently used procedure. In this study, we propose a new method feticide using injection normal saline pericardial space to induce cardiac tamponade, resulting late reduction with minimal maternal risk.A 32-year-old, gravida 6, woman was...

The human endometrium manifests different and distinct morphologies physiologies during the phases of menstrual cycle. We aimed to determine which candidate genes demonstrate differential expression patterns in cycle.Using display reverse transcription polymerase chain reaction compare day 5 18 glandular obtained by laser capture microdissection, we identified a specific gene, NUDT9 (nucleoside diphosphate-linked moiety X motif 9). is known function as highly adenosine diphosphate ribose...

Uterine inversion is a rare postpartum complication. Non-puerperal uterine extremely rare. It mostly occurs with tumors, especially leiomyoma. In most instances, the may not be noticed until time of surgery. The preoperative diagnosis difficult. We report case non-puerperal complete that was initially diagnosed as cervical cancer. preoperatively and she underwent total abdominal hysterectomy bilateral salpingooophorectomy. histological examination showed hemangioma. Accurate important....

Beckwith-Wiedemann syndrome (BWS) is a phenotypically and genetically heterogeneous disorder associated with epigenetic/genetic aberrations on chromosome 11p15.4p15.5. There no consensus criterion for prenatal diagnosis of BWS.Three BWS patients their clinical histories, ultrasonographic features, results molecular were presented. Likewise, by incorporating the findings our cases literature review, phenotypic spectrum genotype-phenotype correlations fetal summarized, practical approach in...

Fetal ductus arteriosus aneurysm (DAA) is a rare but potentially risky congenital heart disease. It often not diagnosed until the third trimester because of its asymptomatic nature and late onset. In occasions, DAA may result in serious complications; therefore, prenatal diagnosis helpful. Herein, we report case foetus with cystic hygroma increased nuchal translucency first (but regressed at 20-week anomalous scan). Karyotyping indicated 46 XY genotype. A large vascular mass was noted apex...

Development of cervical cancer is associated with human papillomavirus (HPV) infection. However, data on comparison among the antibodies anti-E6, anti-E7, and anti-L1 in sera patients or HPV infection are very limited. In this study, we examined expression HPV-18 nonstructural proteins E6, E7, major capsid L1 protein tissues from 25 at stages ranging Ib to IIa, based FIGO staging system. We also used ELISA assess against these (patients) 20 healthy individuals (normal). Western blotting...

Morbidly adhered placentas include the spectrum of accreta, increta, and percreta. Abnormal placentation carries a significant risk hemorrhage when late in gestation especially at peripartum. Many measures including extirpative surgery, selective arterial embolization, methotrexate have been proposed either as single method or combination literature. We report woman with placenta percreta who suffered from massive despite being treated two-stage surgery plus intervening prophylactic uterine...

Oligohydramnios is associated with increased perinatal morbidity and mortality. It may be due to a variety of conditions, including rupture membranes, fetal urinary tract abnormalities such as megacystis caused by posterior urethral valve, prerenal involving uteroplacental insufficiency possibly hypertension, hyperthyroidism. Hyperthyroidism affects 0.2% pregnant women higher risk pre-eclampsia. We report case that presented initially early-onset oligohydramnios later developed hypertensive...