Among the novel robotic platforms, Hugo RAS system is second most studied platform, next to da Vinci system, and we aim address our experiences in radical prostatectomy (RP) with system.We recorded first 12 cases of prostate cancer undergoing RP system. The median console time was 145 min hospital stay 7 days. Hedge' g applied search for cut-off case four parameters surgeries.Pre-console preparation significantly improved after seven cases, remarkably shortened two cases. intraoperative...

Insulin-like growth factor 2 mRNA-binding protein (IGF2BP2), which binds with high affinity to numerous RNA transcripts, is known promote tumorigenesis and metastasis, including in prostate cancer (PCa). Several case-control studies investigated associations between IGF2BP2 polymorphisms progression. However, the effects of genetic variants on clinicopathological progression biochemical recurrence (BCR) PCa remain unclear. In this study, we recruited 698 Taiwanese patients who underwent a...

This study aimed to assess the safety and outcomes of intraoperative ventriculoperitoneal (VP) shunt clamping during robotic-assisted radical prostatectomy (RaRP) in patients with VP shunts. A retrospective analysis nine shunts who underwent RaRP between February 2016 October 2024 was conducted. Data on preoperative prostate-specific antigen (PSA) levels, surgical margins, complications, follow-up durations were collected. Patients stratified into subgroups based PSA levels (≤10 vs. >10...

Background The genus Gardnerella is commonly found in the vaginal ecosystem and considered a covert pathogen of urinary tract. However, vaginalis had been only recognized species for decades. Cases regarding clinical relevance leopoldii have rarely reported, which crucial fully understanding various within . Case presentation A 72-year-old female patient was admitted to hospital with gross hematuria complaints waist soreness. Physical examinations, including those head, chest, abdomen, along...

Abstract Age, ethnic background and genetic components have been identified as the established risks for prostate cancer (PCa). Pentraxin 3 (PTX3), originally a pattern‐recognition molecule defence against infectious agents, has multiple functions in tissue repair regulation of cancer‐associated inflammation. In this study, we sought to investigate impact PTX3 gene variants on development PCa. Genotypes four common single‐nucleotide polymorphisms (SNPs) gene, including rs1840680, rs2305619,...

Timosaponin AIII (TAIII) is a steroidal saponin isolated from Anemarrhena asphodeloides that has been shown to inhibit cell growth and induce apoptosis in cancer. However, the effect of TAIII on acute myeloid leukemia (AML) remains unclear. Here, molecular mechanism by which TAIII-induced affects human AML cells was investigated. The results showed significantly inhibited proliferation four lines (MV4-11, U937, THP-1, HL-60). Furthermore, induced HL-60 through caspase-3, caspase-8, caspase-9...

The association between metal mixtures and kidney function has been reported. However, reports on the mechanism of toxicity were limited. Oxidative stress was reported as a possible cause. This study aimed to determine metals, such arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), lead (Pb), selenium (Se), zinc (Zn), explore mediating role tumor necrosis factor alpha (TNF-α) function. In this study, we recruited 421 adults from health examination. concentration blood metals analyzed...

Background The purpose of this study was to explore the combined effect melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure environmental carcinogens on susceptibility clinicopathological characteristics oral cancer. Methodology Principal Findings Three MTNR1A from 618 patients with cancer 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). CTA haplotype studied (rs2119882, rs13140012, rs6553010) related a higher risk Moreover, exhibited...

Background The gene EZH2, the polycomb group protein enhancer of zeste 2, encodes a transcriptional repressor that also serves as histone methyltransferase is associated with progression to more advanced disease in variety malignancies. EZH2 expression level urothelial cell carcinoma (UCC) highly correlated tumor aggressiveness, but it has not been determined if specific genetic variants are UCC risk. This study investigated potential associations single-nucleotide polymorphisms...

The carcinogenesis of transitional cell carcinoma (TCC) the urinary bladder involves etiological factors, such as ethnicity, environment, genetics, and diet. Cluster differentiation (CD44), a well-known tumor marker, plays crucial role in regulating metastasis. This study investigated effect CD44 single nucleotide polymorphisms (SNPs) on TCC risk clinicopathological characteristics. Five SNPs were analyzed through real-time polymerase chain reaction 275 patients with participants without...

This study investigated the oncological and functional surgical outcomes for patients with renal tumor who underwent robot-assisted partial nephrectomy (PN) by a single surgeon in Taiwan from 2006 to 2019.This retrospective assessed PN tumor. Patient data were analyzed age, sex, body mass index, operative time total ischemic time, margin (positive/negative), complications. To evaluate outcomes, achievement of trifecta, pentafecta criteria was used. Trifecta defined as negative margin, no...

Band selection is a common approach to reduce the data dimensionality of hyperspectral imagery. It extracts several bands importance in some sense by taking advantage high spectral correlation. In medical imaging, narrow-band imaging (NBI) an technique for endoscopic diagnostic tests, where light specific blue and green wavelengths used enhance detail certain aspects surface mucosa. A special filter electronically activated switch endoscope leading use ambient 415 nm (blue) 540 (green)....

Expanded indications are not yet reported for robotic-assisted laparoscopic radical prostatectomy (RARP) performed by experienced surgeons patients with preoperative suspicion of prostate cancer. We report our experience 55 cases prophylactic RARP cancer, including postoperative pathological characteristics and outcomes.This retrospective study reviewed data a subset consecutive among 1,060 who underwent Pathological outcomes suspected cancer were analyzed preoperative, intraoperative...

Radium-223 is an alpha-emitting, bone-targeting radiopharmaceutical that confers a survival benefit in patients with confirmed bone-metastatic, castration-resistant prostate cancer no visceral metastases. We studied real-world use of radium-223 eligible from tertiary hospital.We retrospectively collected clinical data treated Tungs' Taichung MetroHarbor Hospital by chart review. Data included biochemical parameters, pain scores, other treatments received and adverse events (AEs).Of 36 the...

Purpose: This cohort was to evaluate incidental prostate cancer (iPCa) from men with preoperative benign biopsies and demonstrate their outcomes under different managements. Patients Methods: Between 2015 2017, we analyzed the risk factors having iPCa surgical specimens provided of prostates. Furthermore, compared survival according managements after diagnosed. Receiver operating characteristic (ROC) curve utilized find best thresholds. Univariable multivariable nested logit regression were...

Urothelial cell carcinoma (UCC) is the commonest malignant tumor of urinary tract and second most common kidney cancer malignancy. Growth arrest-specific 5 (GAS5), a long noncoding RNA, encoded by GAS5 gene plays critical role in cellular growth arrest apoptosis. In current study, two single nucleotide polymorphisms (SNPs) gene, rs145204276 rs55829688, were selected to investigate correlations between these SNPs susceptibility UCC. A total 430 UCC cases 860 ethnically matched healthy...

The inflammatory process is proposed to be one of the factors benign prostatic enlargement (BPH), and this first study examining anti-inflammatory ability phloretin in treating rats with testosterone-induced BPH. BPH would induced by testosterone (10 mg/kg/day subcutaneously for 28 days), other groups were treated 50 or 100 orally (phr50 phr100 group) after induction. Prostate weight prostate body ratio significantly reduced Phr100 group. Reduced dihydrotestosterone without interfering...

Expanded indications for patients with preoperatively suspected prostate cancer (PC) undergoing theranostic robotic-assisted laparoscopic radical prostatectomy (T-RARP) are reported. We aimed to build a nomogram of T-RARP predict final pathologically proven PC. This study reviewed data 153 that underwent PC performed by the same surgeon.Patients' preoperative demographic and clinical characteristics included age, prostate-specific antigen (PSA) level, PSA density (PSAD), history acute...

Robot-assisted surgery has been used widely in urological since 2000. In Taiwan, robotic started 2004 and progress ongoing this time. Herein we report a case of acute renal failure post robot-assisted radical prostatectomy. The patient received postoperative hemodialysis intensive care. function recovered to serum creatinine level 2.0 mg/dl 2 months after surgical intervention. was still normal the PSA nadir one-year follow-up. outcome is encouraging from point view oncology. To our...

To investigate the distribution of single nucleotide polymorphism (SNP) tissue inhibitor metalloproteinases-3 (TIMP-3) in patients with/without urothelial cell carcinoma (UCC), three loci TIMP-3 SNPs (rs9862 C/T, rs9619311 T/C, rs11547635 C/T) were genotyped via TaqMan allelic discrimination for 424 UCC and 848 non-UCC participants.Furthermore, mRNA expression its correlation with clinical characters bladder was analyzed using The Cancer Genome Atlas database (TCGA).The all 3 studied...

Background: Several reports have revealed the presence of lymph nodes in prostatic anterior fat pad (PAFP). To date, no study has described characteristics Taiwanese patients harboring PAFP with metastatic prostate cancer involvement. Method: Between December 2006 and May 2015, a total 849 consecutive underwent robot-assisted laparoscopic radical prostatectomy dissection. Pathological examination dissected was conducted to assess lymphoid tissue Results: Of patients, 76 (9.0%) had 1-3 nodes....

Abstract Background: Interleukin-2 is the first approved immune-oncology (IO) drug to treat multiple metastatic cancers with durable and curative antitumor effects. Yet, its application restricted due severe toxicity, short half-life, a small fraction of response rate. To reduce toxicity improve efficacy, we developed Vitokine-2, tumor infiltrating lymphocyte (TIL)-targeting, activable, precision engineered IL-2 that remains inert systemically but activated in microenvironment (TME)....

Biochemical recurrence of pathological T2+ localized prostate cancer after robotic-assisted radical prostatectomy: A 10-year surveillance