A5024599430- Hernia repair and management
- Dialysis and Renal Disease Management
- Advanced Causal Inference Techniques
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Pelvic and Acetabular Injuries
- Transplantation: Methods and Outcomes
- Emergency and Acute Care Studies
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Inference
- Organ Transplantation Techniques and Outcomes
- Healthcare Policy and Management
- Renal Transplantation Outcomes and Treatments
- Health disparities and outcomes
- Statistical Methods in Clinical Trials
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Hemodynamic Monitoring and Therapy
- Migraine and Headache Studies
- Rheumatoid Arthritis Research and Therapies
- Bariatric Surgery and Outcomes
- Respiratory Support and Mechanisms
- Hip and Femur Fractures
University of Pennsylvania
2016-2025
Hospital of the University of Pennsylvania
2025
Tungs' Taichung MetroHarbor Hospital
2025
Philadelphia University
2016-2024
California University of Pennsylvania
2021-2024
Connecticut Children's Medical Center
2024
Creative Commons
2018-2023
United States University
2023
Thomas Jefferson University
2021-2022
University of Cincinnati Medical Center
2022
Background: Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but safety long-term use remains uncertain. Objective: To quantify risk hospitalized infection with low-dose in patients RA receiving stable disease-modifying antirheumatic drug (DMARD) therapy. Design: Retrospective cohort study. Setting: Medicare claims data Optum's deidentified Clinformatics Data Mart database from 2006 to 2015. Patients: Adults a DMARD...
Objective The optimal timing of tumor necrosis factor antagonists before elective surgery is unknown. This study evaluated the association between infliximab and serious infection after hip or knee arthroplasty. Methods A retrospective cohort US Medicare patients with rheumatoid arthritis, inflammatory bowel disease, psoriasis, psoriatic ankylosing spondylitis who received within 6 months arthroplasty from 2007 to 2013. Propensity‐adjusted analyses examined whether stop (time most recent...
Survival analysis is commonly used to evaluate factors associated with time an event of interest ( e.g., ESRD, cardiovascular disease, and mortality) among CKD populations. Time the typically observed only for some participants. Other participants have their censored because end study, death, withdrawal from or other competing event. Classic survival methods, such as Cox proportional hazards regression, rely on assumption that any censoring independent interest. However, in most clinical...
Poor metabolic control and host genetic predisposition are critical for diabetic kidney disease (DKD) development. The epigenome integrates information from sequence variations alterations. Here, we performed a genome-wide methylome association analysis in 500 subjects with DKD the Chronic Renal Insufficiency Cohort phenotypes, including glycemic control, albuminuria, function, function decline. We show distinct methylation patterns associated each phenotype. define that underlying...
Background: Patients with rheumatoid arthritis (RA) are at increased risk for infection after arthroplasty, yet risks of specific biologic medications unknown. Objective: To compare postoperative among biologics and to evaluate the associated glucocorticoids. Design: Retrospective cohort study. Setting: Medicare Truven MarketScan administrative data from January 2006 through September 2015. Patients: Adults RA who were having elective inpatient total knee or hip either primary revision, had...
Insulin resistance contributes to the metabolic syndrome, which is associated with development of kidney disease. However, it unclear if insulin independently an increased risk chronic disease (CKD) progression or CKD complications. Additionally, predisposing factors responsible for in absence diabetes are not well described. This study aimed describe and characterize relationship progression, cardiovascular events death among a cohort non-diabetics CKD. Data was utilized from Chronic Renal...
Noninvasive ventilation (NIV) is standard of care in amyotrophic lateral sclerosis (ALS), yet few data exist regarding its benefits.
Background: Prior studies associating acute kidney injury (AKI) with more rapid subsequent loss of function had methodological limitations, including inadequate control for differences between patients who AKI and those did not. Objective: To determine whether is independently associated trajectory among chronic disease (CKD). Design: Multicenter prospective cohort study. Setting: United States. Participants: Patients CKD (n = 3150). Measurements: Hospitalized was defined by a 50% or greater...
Objective Many guidelines recommend limiting glucocorticoids in patients with rheumatoid arthritis (RA), but 40% of remain on long term. We evaluated the cardiovascular risk long‐term glucocorticoid prescription by studying stable disease‐modifying antirheumatic drugs (DMARDs). Methods Using two claims databases, we identified RA DMARD therapy for >180 days. Proportional hazards models inverse‐probability weights and clustering to account multiple observations were used estimate effect...
Summary In medical sciences, statistical analyses based on observational studies are common phenomena. One peril of drawing inferences about the effect a treatment subjects using is lack randomized assignment to treatment. After adjusting for measured pretreatment covariates, perhaps by matching, sensitivity analysis examines impact an unobserved covariate, u, in study. type uses two parameters measure degree departure study from assignment. parameter relates u and other response. For...
Although recommended approaches to CKD management are achieved less often in Hispanics than non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models determine association race/ethnicity, progression (50% eGFR loss or incident ESRD), ESRD, all-cause mortality, linear mixed-effects assess...
Significance Statement Routine incorporation of pragmatic trials into clinical care delivery has potential to generate answers important questions, such as optimal approaches for fundamental components maintenance hemodialysis. The Time Reduce Mortality in ESRD (TiME) trial was a large demonstration project designed determine if hemodialysis session duration longer than many patients the United States currently receive improves outcomes. Although accomplished its objectives, including rapid...
Significance Statement eGFR slope has been used as a surrogate outcome for progression of CKD. However, genetic markers associated with among patients CKD were unknown. We aimed to identify susceptibility loci slope. A two-phase genome-wide association study identified single nucleotide polymorphisms (SNPs) in TPPP and FAT1-LINC02374 , 22 them derive polygenic risk scores that mark the decline by disrupting binding nearby transcription factors. This work is first impact on progression,...
Importance While disparities in consent rates for research have been reported multiple adult and pediatric settings, limited data informing enrollment intensive care unit (PICU) are available. Acute settings such as the PICU present unique challenges study enrollment, given highly stressful emotional environment caregivers time-sensitive nature of studies. Objective To determine whether race ethnicity, language, religion, Social Deprivation Index (SDI) were associated with disparate approach...
ABSTRACT Introduction/Aims Respiratory failure from hypoventilation is the most common cause of death in amyotrophic lateral sclerosis (ALS). However, ALS care rarely assesses hypercapnia, a physiologic measure hypoventilation. We investigated prevalence and clinical significance daytime hypercapnia measured by transcutaneous carbon dioxide (tcCO 2 ) monitoring patients with ALS. Methods This retrospective study included seen at two clinics United States between 2012 2024 who had tcCO...