A5100712408- Aquaculture disease management and microbiota
- Nutritional Studies and Diet
- Cancer Risks and Factors
- Nutrition, Health and Food Behavior
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Invertebrate Immune Response Mechanisms
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Protein Hydrolysis and Bioactive Peptides
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Dermatologic Treatments and Research
- Breast Cancer Treatment Studies
- Enzyme Production and Characterization
- Nutrition, Genetics, and Disease
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
Seoul National University
2018-2025
Pohang University of Science and Technology
2022-2025
Kasumigaura Medical Center
2024
Seoul National University Hospital
2022-2023
Myongji Hospital
2023
Hanyang University
2021-2023
Weatherford College
2023
Semyung University
2022
CHA University
2022
Korea Institute of Toxicology
2019-2021
Abstract Purpose: Human invasive breast cancers (IBC) show enormous histologic and biological diversity. This study comprehensively evaluated diversity in ductal carcinoma situ (DCIS), the immediate precursors of IBCs. Experimental Design: The extent for conventional grade standard prognostic biomarkers assessed by immunohistochemistry was a series pure DCIS (n = 200) compared with contemporaneous IBCs 200). A subset 25) DNA microarrays presence luminal, basal, erbB2 intrinsic subtypes....
Molecular mechanisms mediating the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer remain largely unknown. We used gene expression profiling human DCIS (n = 53) and 51) discover uniquely expressed genes that may also regulate progression. There were 470 total differentially (≥2-fold; P < 0.05). Elevated involved synthesis organization extracellular matrix was particularly prominent epithelium cancer. The degree overlap with nine similar studies literature determined...
Abstract The polarity protein complex Par6/atypical kinase (aPKC)/Cdc42 regulates polarization processes during epithelial morphogenesis, astrocyte migration, and axon specification. We, as well others, have shown that this is also required for disruption of apical-basal the oncogene ErbB2-induced transformation transforming growth factor β–induced epithelial-mesenchymal transition mammary cells. Here, we report expression Par6 by itself in cells induces epidermal factor–independent cell...
Abstract Introduction The hyperplastic enlarged lobular unit (HELU) is a common alteration in adult female human breast and the earliest histologically identifiable lesion with premalignant potential. Growth differentiation normal epithelium are regulated by estrogen progesterone, whose effects mediated through receptor (ER)-α progesterone (PR). We assessed correlations between growth (proliferation apoptosis), endogenous hormone levels (using age as surrogate for menopausal/estrogen...
Pancreatic β cell therapy for type 1 diabetes is limited by low survival rate owing to physical stress and aggressive host immune response. In this study, we demonstrate a multilayer hydrogel nanofilm caging strategy capable of protecting cells from high shear reducing response interfering cell-cell interaction. Hydrogel fabricated monophenol-modified glycol chitosan hyaluronic acid that cross-link each other form nanothin film on the surface via tyrosinase-mediated reactions. Furthermore,...
Excessive proliferation of vascular smooth muscle cells (VSMCs) and neointimal formation are critical steps in the pathogenesis atherosclerosis restenosis after percutaneous transluminal angioplasty. In this study, we investigated hypothesis that activator protein-1 (AP-1) plays an important role injury. A circular dumbbell AP-1 decoy oligodeoxynucleotide (CDODN) was developed as a novel therapeutic strategy for This CDODN more stable than conventional phosphorothioate linear ODN (PSODN)...
Objective: This study investigated the anti-aging effects of dietary isoflavones on photoaged hairless mouse skin.Methods: Female mice were administered soy isoflavone extract orally and irradiated with UV light for four weeks. The skin appearance, collagen deposition epidermal thickness in UV-damaged measured using bioengineering histochemical methods. In addition, influence metabolism UVB-irradiated human fibroblasts was also investigated.Results: treated group, had a better appearance...
Soy products are mainly composed of proteins, phytochemicals such as isoflavones, soy lipids, and carbohydrates. It is unclear whether an individual component alone or a combined effect multiple bioactive compounds contributes to the beneficial properties soy. We investigated dietary genistein (the principal isoflavone) with L-carnitine evaluate possible synergistic effects on intentionally induced prediabetic state characterized by insulin resistance obesity in C57Bl/6J mice fed high-fat...
The dependence of global green tea metabolome on plucking positions was investigated through (1)H nuclear magnetic resonance (NMR) analysis coupled with multivariate statistical data set. Pattern recognition methods, such as principal component (PCA) and orthogonal projection latent structure-discriminant (OPLS-DA), were employed for a finding metabolic discrimination among fresh leaves plucked at different from young to old leaves. In addition clear leaves, elevations in theanine, caffeine,...
Significance Statement eGFR slope has been used as a surrogate outcome for progression of CKD. However, genetic markers associated with among patients CKD were unknown. We aimed to identify susceptibility loci slope. A two-phase genome-wide association study identified single nucleotide polymorphisms (SNPs) in TPPP and FAT1-LINC02374 , 22 them derive polygenic risk scores that mark the decline by disrupting binding nearby transcription factors. This work is first impact on progression,...
The comprehensive quantitative analysis of the flavonoid chemistry Artemisia vulgaris L., a plant used as an emmenagogue in traditional medicine, is presented conjunction with evaluation its estrogenic activity. Twenty known flavonoids were isolated and identified tricine, jaceosidine, eupafolin, chrysoeriol, diosmetin, homoeriodictyol, isorhamnetin, apigenin, eriodictyol, luteolin, luteolin 7-glucoside, kaempferol 3-glucoside, 3-rhamnoside, 3-rutinoside, quercetin 3-galactoside, quercetrin,...
Abstract A glycan‐stimulated and poly(3,4‐ethylene‐dioxythiophene)s (PEDOT)‐based nanomaterial platform is fabricated to purify circulating tumor cells (CTCs) from blood samples of prostate cancer (PCa) patients. This new platform, phenylboronic acid (PBA)‐grafted PEDOT NanoVelcro, combines the 3D nanosubstrate, which greatly enhances CTC capturing efficiency, with a poly(EDOT‐PBA‐ co ‐EDOT‐EG3) interfacial layer, not only provides high specificity for capture upon antibody conjugation but...
Abstract Psychostimulants, including cocaine, elicit stereotyped, addictive behaviors. The reemergence of silent synapses containing only NMDA-type glutamate receptors is a critical mediator addiction memory and seeking Despite the predominant abundance GluN2B-containing in synapses, their operational mechanisms are not fully understood. Here, using conditional depletion/deletion GluN2B D1-expressing accumbal medium spiny neurons, we examined synaptic behavioral actions that incur after...
Tobacco smoking is a major public health concern worldwide. This study aimed to assess its impact on cancer incidence and mortality by estimating the population attributable fraction (PAF) in Korean for 2015 2020 projecting future trends until 2030. The relative risk (RR) was calculated via meta-analysis of RRs individual cancers attributed tobacco smoking, based primary data analysis from Cohort Consortium. PAF estimated using Levin formula with past current prevalence rates number cases...
This study aimed to determine the population-attributable fractions (PAFs) of cancers using various calculation methods and estimate PAFs cancer incidence mortality resulting from deficit in physical activity (DPA) 2015 2030, based on data prevalence rates. The PAF was estimated a cohort study-based meta-analysis relative risk (RR), national rates DPA 2000 2015, statistics with latency 15 years. In contributed 909 cases 548 deaths, accounting for 0.42% 0.68% new respectively. By values are...