A5103104619- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Hepatitis B Virus Studies
- Gastrointestinal disorders and treatments
- Hepatitis C virus research
- Nasal Surgery and Airway Studies
- Esophageal and GI Pathology
- Head and Neck Surgical Oncology
- Veterinary medicine and infectious diseases
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Liver physiology and pathology
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Obstructive Sleep Apnea Research
- Metastasis and carcinoma case studies
- Protein Kinase Regulation and GTPase Signaling
- Eosinophilic Esophagitis
- Sinusitis and nasal conditions
- Cellular Mechanics and Interactions
- Gastrointestinal Tumor Research and Treatment
- Airway Management and Intubation Techniques
- Cancer Genomics and Diagnostics
- Microscopic Colitis
Tzu Chi University
2011-2024
Tzu Chi Foundation
2014-2024
Buddhist Tzu Chi General Hospital
2010-2021
Hualien Tzu Chi Medical Center
2019
National Taiwan University
2019
Chi Mei Medical Center
2014
University of Cambridge
2001
Abstract Background & Aims Oral antiviral therapy may reduce the disease progression of chronic hepatitis B ( CHB ) patients. We aimed to further investigate efficacy long‐term entecavir in reduction risk hepatocellular carcinoma HCC ), cirrhotic events and mortality a large group ‐related cirrhosis Methods The C‐ TEAM (Cirrhosis‐Taiwanese EntecAvir Multicenter) study was nationwide, multicenter, retrospective–prospective cohort Taiwan. enrolled treatment‐naïve patients with baseline HBV...
Taiwan was an endemic area for hepatitis B virus (HBV) infection, and related liver diseases cause a significant drain of public resources. To control the endemic, nation-wide newborn vaccination program started in 1985. We reviewed results annual survey HBV surface antigen (HBsAg) performed freshmen class two high schools Hualien, eastern Taiwan, from 1991 to 2001. A total 10,194 students, most them 15 years old, were tested serum HBsAg using enzyme immunoassays. There is trend (P < 0.0001)...
Prevalence of Helicobacter pylori (H. pylori) strains resistant to metronidazole, clarithromycin and amoxicillin is increasing worldwide. The aim this study was determine the antibiotic susceptibility patterns in H. isolated from eastern Taiwan.One strain each 133 symptomatic patients subjected determination minimal inhibitory concentration (MIC) by Epsilometer test (E-test) for four antibiotics commonly used treatment infections.None were tetracycline. Resistance metronidazole (8...
Snail is a multifunctional transcriptional factor that has been described as repressor in many different contexts. It also proposed an activator few cases relevant to tumor progression and cell-cycle arrest. This study investigated the detailed mechanisms by which upregulates gene expression of CDK inhibitor p15(INK4b) HepG2 induced promoter tetradecanoyl phorbol acetate (TPA). Using deletion mapping, TPA-responsive element on was located between 77 228 bp upstream initiation site, within...
Aberrant methylation of the promoter, P2, and first exon, E1, regions tumor suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC), albeit poor specificity. This study analyzed profiles P1, P2 E1 to identify region which most specifically corresponds HCC evaluate potential this methylated as a biomarker in urine for screening.Bisulfite DNA sequencing quantitative methylation-specific polymerase chain reaction assays were performed compare 56 CpG sites isolated from...
Abstract The relationship of HLA phenotype and outcome hepatitis B virus (HBV) infection was studied in two ethnic groups Taiwan: Han Chinese Taiwanese Aborigines. In Chinese, the study consisted 98 persons who tested both surface antigen (HBsAg) anti‐HBs negative (Uninfected Group), 324 HBsAg anti‐HBc positive (Recovered patients for at least 6 months (Chronically Infected Group). Aborigines, 34 Uninfected Group, 229 Recovered 138 Chronically Group. All subjects were (A, B, DRB1) phenotypes...
// Jia-Ru Wu 1 , Chi-Tan Hu 3 Ren-In You 2 Siou-Mei Pan Chuan-Chu Cheng Ming-Che Lee 4 Chao-Chuan 5 Yao-Jen Chang Shu-Chuan Lin Chang-Shan Chen Teng-Yi 6 Wen-Sheng Institute of Medical Sciences, College Medicine, Tzu Chi University, Hualien, Taiwan Department Laboratory Medicine and Biotechnology, Research Centre for Hepatology, Internal Buddhist General Hospital Surgery, Hospital, School Taipei Foundation, Hualien Correspondence to: Wu, e-mail: wuwstcu1234@yahoo.com.tw Keywords: HGF,...
Hepatocyte growth factor (HGF) and its receptor c-Met were frequently deregulated in hepatocellular carcinoma (HCC). Signaling pathways activated by HGF-c-Met are promising targets for preventing HCC progression. HGF can induce the reactive oxygen species (ROS) signaling cell adhesion, migration invasion of tumors including HCC. On other hand, extracellular signal-regulated kinases (ERK), member mitogen kinase, be ROS a lot cellular processes. As expected, HGF-induced phosphorylation ERK...
Hepatocellular carcinoma (HCC) is among the most lethal cancers. Mounting studies highlighted essential role of HGF/c-MET axis in driving HCC tumor progression. Therefore, c-Met a potential therapeutic target for HCC. However, several concerns remain unresolved targeting. First, status active must be screened to determine patients suitable therapy. Second, resistance and side effects have been observed frequently when using conventional inhibitors. Thus, preclinical system screening...
The bismuth-based quadruple regimen has been applied in Helicobacter pylori rescue therapy worldwide. non-bismuth-based or “concomitant therapy” is an alternative option first-line eradication but not used second-line therapy. Discovering a valid for bismuth-unavailable countries important. We conducted randomized controlled trial to compare the efficacies of standard and modified concomitant regimen. One hundred twenty-four patients were randomly assigned into two groups: RBTM (rabeprozole...
The resistance rates of Helicobacter pylori to amoxicillin and metronidazole therapy are higher in eastern Taiwan as compared national worldwide rates. high rate this territory justified a search for better eradication regimen. We conducted an open-labeled, prospective, randomized, controlled study tertiary referral hospital Taiwan. Between December 2007 2009, total 153 -positive, therapy-naïve patients with positive rapid urease test were recruited random assignment two seven-day treatment...
BACKGROUND Ultrathin transnasal esophagogastroduodenoscopy (UT-EGD) is well tolerated by patients, but the methods of nasal anesthesia are various. AIM To compare patient tolerance, safety, and adverse events between endoscopic-guided (EGNA) cotton-tipped applicator (CTNA) anesthesia. METHODS Between September 2005 2006, we conducted a prospective, randomized, controlled study in large tertiary referral hospital eastern Taiwan. In total, 235 consecutive patients were randomly assigned to...
Strongyloidiasis, caused by Strongyloides stercoralis, is endemic in tropical and subtropical regions. Whether or not the infection rate higher among indigenous populations Taiwan remains unclear. The aim of our study was to assess racial demographics, diagnoses clinical details strongyloidiasis. A total 41 patients (27 males 14 females) with strongyloidiasis at a tertiary referral centre eastern 21-year period were investigated retrospectively. majority (36/41, 88%) these lived rural...
Detection of human hepatitis B virus (HBV) DNA in the urine patients with chronic infection (CHB) has been reported previously, suggesting could provide a potential route horizontal HBV transmission. However, it is not clear whether detected indeed full-length, infectious viral DNA. The aim this study to assess infectivity from CHB and correlate detection clinical parameters, such as serum load HBeAg status. Urine 60 loads ranging undetectable 108 IU/mL were analyzed for immune markers. was...
ABSTRACT The genotypes of Helicobacter pylori flaA , cagA vacA and iceA were determined for DNA isolated from patients with chronic gastritis or peptic ulcer in eastern Taiwan. gene encoding the s1a subtype was found to predominate patients, iceA1 genotype associated gastritis. genes not be these types disease.