A5060384760- Lymphoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Anesthesia and Pain Management
- Immune Response and Inflammation
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Cutaneous lymphoproliferative disorders research
- Immunodeficiency and Autoimmune Disorders
- Agricultural Economics and Policy
- Systemic Lupus Erythematosus Research
- CAR-T cell therapy research
- Nausea and vomiting management
- Trauma Management and Diagnosis
- Blood disorders and treatments
- Viral-associated cancers and disorders
University of Pennsylvania
2022
Center for Rheumatology
2020
Oklahoma Medical Research Foundation
2019
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) an environmental factor associated SLE. EBV maintains latency in B cells frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early (EA). In this study, we determined whether single nucleotide polymorphisms (SNPs) EBV-associated host genes are SLE transition. Methods patient relatives (n=436) who did not have at baseline were...
Inborn errors of immunity (IEI) are a genetically heterogeneous group disorders with broad clinical spectrum. Identification molecular and functional bases these is important for diagnosis, treatment, an understanding the human immune response. We identified 6 unrelated males neutropenia, infections, lymphoproliferation, humoral defects, in some cases bone marrow failure associated 3 different variants X-linked gene TLR8, encoding endosomal Toll-like receptor 8 (TLR8). Interestingly, 5...
Cutaneous T-cell lymphoma (CTCL) remains a challenging disease due to its significant heterogeneity, therapy resistance, and relentless progression. Multi-omics technologies offer the potential provide uniquely precise views of progression response therapy. We present here comprehensive multi-omics view CTCL clonal evolution, incorporating exome, whole genome, epigenome, bulk-, single cell (sc) VDJ-, scRNA-sequencing 114 clinically annotated serial skin, peripheral blood, lymph node samples...
To assess the effect of intraoperative cryoablation on postoperative patient-reported pain, opioid use, and clinical outcomes in lung transplantation.We performed a single-center retrospective cohort study adult transplant recipients from August 2017 to September 2018. We compared patients who received intercostal nerves with those did not. Primary were pain scores use. Secondary included sedation agitation levels perioperative outcomes. Data abstracted patients' electronic health records.Of...