A5065514371- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Magnolia and Illicium research
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Spinal Hematomas and Complications
- Oxidative Organic Chemistry Reactions
- Galectins and Cancer Biology
- Systemic Sclerosis and Related Diseases
- Liver Diseases and Immunity
- Renal Diseases and Glomerulopathies
- Alcohol Consumption and Health Effects
- Protein Tyrosine Phosphatases
- interferon and immune responses
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
Oklahoma Medical Research Foundation
2015-2024
Czech Academy of Sciences, Institute of Microbiology
2006-2010
University of Iowa
2004-2009
Iowa City Public Library
2004
Foundation for the National Institutes of Health
2001
Northwestern University
1996
The relationship of immune dysregulation and autoantibody production that may contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study evaluates the individual combined contributions autoantibodies, type I interferon (IFN-α) activity, IFN-associated soluble mediators disease development leading SLE.Serial serum specimens from 55 individuals collected prior SLE classification (average timespan=4.3 years) unaffected healthy controls matched by age (±5 years),...
Objective Antinuclear antibodies (ANAs) are detected in ∼18% of females, yet autoimmune disease develops only 5–8%. Immunologic differences between ANA‐positive healthy individuals and patients with systemic lupus erythematosus (SLE) may elucidate the regulatory mechanisms by which avoid transition to clinical disease. Methods Healthy (n = 790) were screened for autoantibodies specific 11 antigens associated lupus, sclerosis, Sjögren's syndrome. From this screening, 31 European American...
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) an environmental factor associated SLE. EBV maintains latency in B cells frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early (EA). In this study, we determined whether single nucleotide polymorphisms (SNPs) EBV-associated host genes are SLE transition. Methods patient relatives (n=436) who did not have at baseline were...
The clinical and pathologic diversity of systemic lupus erythematosus (SLE) hinders diagnosis, management, treatment development. This study addresses heterogeneity in SLE through comprehensive molecular phenotyping machine learning clustering. Adult patients (n = 198) provided plasma, serum, RNA. Disease activity was scored by modified SELENA-SLEDAI. Twenty-nine co-expression module scores were calculated from microarray gene-expression data. Plasma soluble mediators 23) autoantibodies 13)...
Abstract Honokiol (HNK), a phenolic compound isolated and purified from magnolia, has been found to have number of pharmacologic benefits, including anti-angiogenic anti-inflammatory properties. HNK long used in traditional Asian medicine without toxic side effects. We others extensively studied signaling B cells by CD40 its Epstein Barr viral mimic, latent membrane protein 1 (LMP1), which implicated exacerbation chronic autoimmune disease. asked whether could inhibit LMP1 inflammatory...
TNFR-associated factor 1 (TRAF1) is unique among the TRAF family, lacking most zinc-binding features, and showing marked up-regulation following activation signals. However, biological roles that TRAF1 plays in immune cell signaling have been elusive, with many reports assigning contradictory to TRAF1. The overlapping binding site for TRAFs 1, 2, 3 on TNFR superfamily molecules, together early lethality of mice deficient 2 3, has complicated quest a clear understanding functions Using new...
CD40 plays a significant role in the pathogenesis of inflammation and autoimmunity. B cell directly activates cells, which can result autoantibody production. T cells also express CD40, with an increased frequency amount expression seen CD4(+) lymphocytes autoimmune mice, including from mice collagen-induced arthritis. However, mechanisms function have not been clearly defined. To test hypothesis that serve as costimulatory molecule on lymphocytes, CD40(+) arthritis were examined parallel...
Objective Systemic lupus erythematosus (SLE) is a multifaceted disease characterized by immune dysregulation and unpredictable activity. This study sought to evaluate the changes in plasma concentrations of soluble mediators that precede clinically defined flares. Methods Fifty‐two different mediators, including cytokines, chemokines, receptors, were examined using validated multiplex bead‐based or enzyme‐linked immunosorbent assays from 28 European American patients with SLE who developed...
Decreased heart rate variability (HRV) is associated with adverse outcomes in cardiovascular diseases and has been observed patients systemic lupus erythematosus (SLE). We examined the relationship of HRV SLE disease activity selected cytokine pathways. Fifty-three from Oklahoma Lupus Cohort were evaluated at two visits each. Clinical assessments included Systemic Erythematosus Disease Activity Index (SLEDAI), British Isles Assessment Group (BILAG) index, physician global assessment (PGA),...
Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim this study was to identify factors associated with transition classified disease that would inform our understanding the SLE.
Abstract Objective To address heterogeneity complicating primary SS (pSS) clinical trials, research and care by characterizing clustering patients their molecular phenotypes. Methods pSS met American–European Consensus Group classification criteria had at least one systemic manifestation stimulated salivary flow of ⩾0.1 ml/min. Correlated transcriptional modules were derived from gene expression microarray data blood (n = 47 with appropriate samples). Patients clustered based on this...
We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE.436 who reported having a relative SLE but did not have themselves evaluated baseline and again an average 6.3 (±3.9) years later. Fifty-six transitioned (≥4 cumulative American College Rheumatology criteria). 25-Hydroxyvitamin (25[OH]D) levels measured by ELISA. Six single-nucleotide polymorphisms four genes genotyped. Generalised estimating...
Background: Chronic alcohol consumption polarizes the immune response away from Th1‐mediated cell‐mediated immunity. In present report we investigate first onset of alteration in parameters during ethanol terms changes splenic leukocyte cellularity and surface phenotype as well alterations Th1 Th2 function. Methods: BALB/c C57BL/6 mice were fed ethanol‐containing liquid diets, pair‐fed an isocaloric control diet, or solid diet water ad libitum for up to 12 days. At intervals feeding period,...
Chronic airway inflammation is a hallmark of asthma, an immune-based disease with great societal impact. Honokiol (HNK), phenolic neurotransmitter receptor (γ-aminobutyric acid type A) agonist purified from magnolia, has anti-inflammatory properties, including stabilization in experimentally induced arthritis. The present study tested the prediction that HNK could inhibit chronic inflammatory component allergic asthma. C57BL/6 mice sensitized to and challenged OVA had increased...
Background The role of sleep in the etiology systemic lupus erythematosus (SLE) has not been well studied. We examined whether duration was associated with subsequent transitioning to SLE individuals at risk for SLE. Methods Four hundred and thirty-six relatives patients who did have themselves baseline were evaluated again an average 6.3 (± 3.9) years later. Fifty-six transitioned (≥ 4 cumulative American College Rheumatology (ACR) criteria). Sleep duration, medication use medical history...
Systemic lupus erythematosus (SLE) and other autoimmune diseases are propelled by immune dysregulation pathogenic, disease-specific autoantibodies. Autoimmunity against the autoantigen Sm is associated with cross-reactivity to Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1). Additionally, EBV latent membrane protein-1 (LMP1), initially noted for its oncogenic activity, an aberrantly active functional mimic of B cell co-stimulatory molecule CD40. Mice expressing a transgene (Tg)...