A5074123269- Retinal Development and Disorders
- Axon Guidance and Neuronal Signaling
- Cellular transport and secretion
- Renal and related cancers
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Retinopathy of Prematurity Studies
- Cell Image Analysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Corneal Surgery and Treatments
- Ocular Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
University of Aberdeen
2009-2017
Significance Our findings demonstrate a function for Down syndrome cell adhesion molecule (DSCAM) in the embryonic development of mouse visual system. We found that DSCAM promotes fasciculation and growth axons developing optic pathway, at least part, through homotypic interactions. also shed can act independently direct cell–cell contact to provide growth-promoting signals. Because Dscam mutant phenotypes are mediated dose-dependent manner, these results potentially relevant human syndrome,...
Visual information is relayed from the eye to brain via retinal ganglion cell (RGC) axons. Mice lacking NRP1 or NRP1-binding VEGF-A isoforms have defective RGC axon organisation alongside vascular defects. It not known whether axonal defects are caused exclusively by signalling in RGCs exacerbated abnormal morphology. Targeted ablation with a Brn3bCre knock-in allele reduced midline crossing at optic chiasm and tract fasciculation. In contrast, Tie2-Cre-mediated endothelial induced exclusion...